Glucose-6-phosphate dehydrogenase and NADPH oxidase 4 control STAT3 activity in melanoma cells through a pathway involving reactive oxygen species, c-SRC and SHP2

Glucose-6-phosphate dehydrogenase (G6PD) participates in glucose utilization by catalysing the first step of the pentose-phosphate pathway in mammalian cells. Previous studies have shown that changes in G6PD levels can promote tumor cell proliferation or apoptosis via the STAT3/5 pathway in a human...

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Veröffentlicht in:	American journal of cancer research 2015-01, Vol.5 (5), p.1610-1620
Hauptverfasser:	Cai, Tianchi, Kuang, Yingmin, Zhang, Chunhua, Zhang, Zheng, Chen, Long, Li, Bo, Li, Yuqian, Wang, Yanling, Yang, Huixin, Han, Qiaoqiao, Zhu, Yuechun
Format:	Artikel
Sprache:	eng
Schlagworte:	Original
Online-Zugang:	Volltext
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