Regulation of mTOR Signaling by Semaphorin 3F-Neuropilin 2 Interactions In Vitro and In Vivo

Semaphorin 3F (SEMA3F) provides neuronal guidance cues via its ability to bind neuropilin 2 (NRP2) and Plexin A family molecules. Recent studies indicate that SEMA3F has biological effects in other cell types, however its mechanism(s) of function is poorly understood. Here, we analyze SEMA3F-NRP2 si...

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Veröffentlicht in:	Scientific reports 2015-07, Vol.5 (1), p.11789-11789, Article 11789
Hauptverfasser:	Nakayama, Hironao, Bruneau, Sarah, Kochupurakkal, Nora, Coma, Silvia, Briscoe, David M., Klagsbrun, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	13/51 38/109 38/79 42/89 631/337 631/80/86 64/60 82/80 Actins - metabolism AKT protein Animals Axon guidance Biological effects Cell growth Cell Line, Tumor Chronic illnesses Cytoskeleton Disease Models, Animal Guanosine triphosphatases Heterografts Humanities and Social Sciences Humans Hypoxia - metabolism Immunoprecipitation Kinases Lymphocytes T Mechanistic Target of Rapamycin Complex 1 Mechanistic Target of Rapamycin Complex 2 Medical schools Membrane Proteins - genetics Membrane Proteins - metabolism Mice Models, Biological multidisciplinary Multiprotein Complexes - metabolism Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Neovascularization, Pathologic - metabolism Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neuropilin Neuropilin-2 - metabolism Phosphorylation Protein Binding Proto-Oncogene Proteins c-akt - metabolism Regulation RhoA protein Ribosomal Protein S6 Kinases - metabolism Science Semaphorins Signal Transduction TOR protein TOR Serine-Threonine Kinases - metabolism Tumor Burden Tumor cells Vascular endothelial growth factor Vascular Endothelial Growth Factor A - metabolism Xenografts
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