MicroRNA profiling identifies MiR-195 suppresses osteosarcoma cell metastasis by targeting CCND1

Metastasis is a leading cause of mortality for osteosarcoma patients. The molecular pathological mechanism remains to be elucidated. In the previously study, we established two osteosarcoma cell lines with different metastatic potentials. Differential expressed genes and proteins regarding metastati...

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Veröffentlicht in:	Oncotarget 2015-04, Vol.6 (11), p.8875-8889
Hauptverfasser:	Han, Kang, Chen, Xiang, Bian, Na, Ma, Baoan, Yang, Tongtao, Cai, Chengkui, Fan, QingYu, Zhou, Yong, Zhao, Ting Bao
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Animals Bone Neoplasms - genetics Bone Neoplasms - mortality Bone Neoplasms - pathology Cell Line, Tumor - transplantation Cell Movement Cyclin D1 - biosynthesis Cyclin D1 - genetics Female Gene Expression Regulation, Neoplastic Gene Knockdown Techniques Heterografts Humans Lung Neoplasms - genetics Lung Neoplasms - prevention & control Male Mice Mice, Inbred BALB C Mice, Nude MicroRNAs - physiology Neoplasm Invasiveness Osteosarcoma - genetics Osteosarcoma - mortality Osteosarcoma - secondary Proportional Hazards Models Recombinant Fusion Proteins - metabolism Research Paper RNA, Neoplasm - biosynthesis RNA, Neoplasm - genetics RNA, Neoplasm - physiology Tissue Array Analysis Young Adult
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