Ubiquitination of CD86 is a key mechanism in regulating antigen presentation by dendritic cells

Dendritic cells (DCs) require costimulatory molecules such as CD86 to efficiently activate T cells for the induction of adaptive immunity. DCs maintain minimal levels of CD86 expression at rest, but upregulate levels upon LPS stimulation. LPS-stimulated DCs produce the immune suppressive cytokine IL...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of immunology (1950) 2011-09, Vol.187 (6), p.2966-2973
Hauptverfasser:	Baravalle, Günther, Park, Hyesuk, McSweeney, Megan, Ohmura-Hoshino, Mari, Matsuki, Yohei, Ishido, Satoshi, Shin, Jeoung-Sook
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigen Presentation - immunology B7-2 Antigen - immunology B7-2 Antigen - metabolism Blotting, Western Cell Separation Dendritic Cells - immunology Dendritic Cells - metabolism Flow Cytometry Gene Expression Gene Expression Regulation - immunology Immunoprecipitation Lymphocyte Activation - immunology Mice Mice, Inbred C57BL Reverse Transcriptase Polymerase Chain Reaction T-Lymphocytes - immunology Ubiquitin-Protein Ligases - immunology Ubiquitin-Protein Ligases - metabolism Ubiquitination - immunology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!