Spectrum of renal involvement in hematolymphoid neoplasms: Renal biopsy findings of 12 cases
Spectrum of causes for renal dysfunction in patients with hematolymphoid malignancy (excluding plasma cell dyscrasia) is varied. A retrospective evaluation of "native" renal biopsies referred to our institute during the period from January 2010 to December 2013 revealed 12 cases. Age range...
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| Veröffentlicht in: | Indian journal of nephrology 2015-07, Vol.25 (4), p.201-205 |
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| creator | Vankalakunti, M Rohan, A Vishwanath, S Rampure, S Bonu, R Babu, K Ballal, H S |
| description | Spectrum of causes for renal dysfunction in patients with hematolymphoid malignancy (excluding plasma cell dyscrasia) is varied. A retrospective evaluation of "native" renal biopsies referred to our institute during the period from January 2010 to December 2013 revealed 12 cases. Age ranged between 7 and 69 (median 54.5) years. All patients were males. The neoplasms included non-Hodgkin lymphoma, chronic lymphocytic leukemia, acute lymphoblastic leukemia, Burkitt's lymphoma, intravascular lymphoma, Hodgkin lymphoma and chronic myeloid leukemia. Proteinuria was noted in 66% of the patients (nephrotic range in 5, subnephrotic range in 3). Renal insufficiency was noted in 100% patients. Malignancy-related kidney injury was noted in 75% of the cases. Renal histology showed lymphomatous infiltration (8), membranoproliferative glomerulonephritis (MPGN) (3), intracapillary monoclonal deposit disease (1) and intravascular lymphoma (1). Distribution of lymphomatous infiltration was diffuse in 50% and focal in 50%. We observed that renal dysfunction was predominantly a direct effect, that is, lymphomatous invasion. Paraneoplastic glomerulopathic changes occur in the form of MPGN. Proteinuria of >2 g/day correlated with glomerular disease. |
| doi_str_mv | 10.4103/0971-4065.139093 |
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A retrospective evaluation of "native" renal biopsies referred to our institute during the period from January 2010 to December 2013 revealed 12 cases. Age ranged between 7 and 69 (median 54.5) years. All patients were males. The neoplasms included non-Hodgkin lymphoma, chronic lymphocytic leukemia, acute lymphoblastic leukemia, Burkitt's lymphoma, intravascular lymphoma, Hodgkin lymphoma and chronic myeloid leukemia. Proteinuria was noted in 66% of the patients (nephrotic range in 5, subnephrotic range in 3). Renal insufficiency was noted in 100% patients. Malignancy-related kidney injury was noted in 75% of the cases. Renal histology showed lymphomatous infiltration (8), membranoproliferative glomerulonephritis (MPGN) (3), intracapillary monoclonal deposit disease (1) and intravascular lymphoma (1). Distribution of lymphomatous infiltration was diffuse in 50% and focal in 50%. We observed that renal dysfunction was predominantly a direct effect, that is, lymphomatous invasion. Paraneoplastic glomerulopathic changes occur in the form of MPGN. Proteinuria of >2 g/day correlated with glomerular disease.</description><identifier>ISSN: 0971-4065</identifier><identifier>EISSN: 1998-3662</identifier><identifier>DOI: 10.4103/0971-4065.139093</identifier><identifier>PMID: 26199470</identifier><language>eng</language><publisher>India: Medknow Publications and Media Pvt. Ltd</publisher><subject>Complications and side effects ; Forecasts and trends ; Kidney diseases ; Lymphatic diseases ; Medical statistics ; Original ; Risk factors</subject><ispartof>Indian journal of nephrology, 2015-07, Vol.25 (4), p.201-205</ispartof><rights>COPYRIGHT 2015 Medknow Publications and Media Pvt. Ltd.</rights><rights>Copyright Medknow Publications & Media Pvt Ltd Jul 2015</rights><rights>Copyright: © Indian Journal of Nephrology 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4373-c224cbe19c5131b5b9bf865a4ea61273dc07789669a9a491c60241fb84b869a43</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4495473/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4495473/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,886,27926,27927,53793,53795</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26199470$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vankalakunti, M</creatorcontrib><creatorcontrib>Rohan, A</creatorcontrib><creatorcontrib>Vishwanath, S</creatorcontrib><creatorcontrib>Rampure, S</creatorcontrib><creatorcontrib>Bonu, R</creatorcontrib><creatorcontrib>Babu, K</creatorcontrib><creatorcontrib>Ballal, H S</creatorcontrib><title>Spectrum of renal involvement in hematolymphoid neoplasms: Renal biopsy findings of 12 cases</title><title>Indian journal of nephrology</title><addtitle>Indian J Nephrol</addtitle><description>Spectrum of causes for renal dysfunction in patients with hematolymphoid malignancy (excluding plasma cell dyscrasia) is varied. A retrospective evaluation of "native" renal biopsies referred to our institute during the period from January 2010 to December 2013 revealed 12 cases. Age ranged between 7 and 69 (median 54.5) years. All patients were males. The neoplasms included non-Hodgkin lymphoma, chronic lymphocytic leukemia, acute lymphoblastic leukemia, Burkitt's lymphoma, intravascular lymphoma, Hodgkin lymphoma and chronic myeloid leukemia. Proteinuria was noted in 66% of the patients (nephrotic range in 5, subnephrotic range in 3). Renal insufficiency was noted in 100% patients. Malignancy-related kidney injury was noted in 75% of the cases. Renal histology showed lymphomatous infiltration (8), membranoproliferative glomerulonephritis (MPGN) (3), intracapillary monoclonal deposit disease (1) and intravascular lymphoma (1). Distribution of lymphomatous infiltration was diffuse in 50% and focal in 50%. We observed that renal dysfunction was predominantly a direct effect, that is, lymphomatous invasion. Paraneoplastic glomerulopathic changes occur in the form of MPGN. Proteinuria of >2 g/day correlated with glomerular disease.</description><subject>Complications and side effects</subject><subject>Forecasts and trends</subject><subject>Kidney diseases</subject><subject>Lymphatic diseases</subject><subject>Medical statistics</subject><subject>Original</subject><subject>Risk factors</subject><issn>0971-4065</issn><issn>1998-3662</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkktr3DAUhUVpaCZp910VQ6Fk46lelq0uCiH0EQgE-tgVhCzLYwU9XMkemH9fOZNOM6FoIXHvd4-kwwHgNYJriiB5D3mNSgpZtUaEQ06egRXivCkJY_g5WB3ap-AspTsIcUV59QKcYpYxWsMV-PV91GqKsytCX0TtpS2M3wa71U77KZ-LQTs5Bbtz4xBMV3gdRiuTSx-Kb_d4a8KYdkVvfGf8Ji06CBdKJp1egpNe2qRfPezn4OfnTz-uvpY3t1-ury5vSkVJTUqFMVWtRlxViKC2annbN6ySVEuGcE06Beu64YxxySXlSDGIKerbhrZNrlFyDj7udce5dbpT-eVRWjFG42TciSCNOO54M4hN2Aqa7aA1yQIXDwIx_J51moQzSWlrZf7unARivCFNwznL6Nsn6F2YYzbinmKYVqzm_6iNtFoY34d8r1pExSXFkEGEG5Sp9X-ovDrtjApe9ybXjwbePRoYtLTTkIKdJxN8OgbhHlQxpBR1fzADQbFERyzZEEs2xD46eeTNYxMPA3-zQv4A5Ba8AQ</recordid><startdate>20150701</startdate><enddate>20150701</enddate><creator>Vankalakunti, M</creator><creator>Rohan, A</creator><creator>Vishwanath, S</creator><creator>Rampure, S</creator><creator>Bonu, R</creator><creator>Babu, K</creator><creator>Ballal, H S</creator><general>Medknow Publications and Media Pvt. 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A retrospective evaluation of "native" renal biopsies referred to our institute during the period from January 2010 to December 2013 revealed 12 cases. Age ranged between 7 and 69 (median 54.5) years. All patients were males. The neoplasms included non-Hodgkin lymphoma, chronic lymphocytic leukemia, acute lymphoblastic leukemia, Burkitt's lymphoma, intravascular lymphoma, Hodgkin lymphoma and chronic myeloid leukemia. Proteinuria was noted in 66% of the patients (nephrotic range in 5, subnephrotic range in 3). Renal insufficiency was noted in 100% patients. Malignancy-related kidney injury was noted in 75% of the cases. Renal histology showed lymphomatous infiltration (8), membranoproliferative glomerulonephritis (MPGN) (3), intracapillary monoclonal deposit disease (1) and intravascular lymphoma (1). Distribution of lymphomatous infiltration was diffuse in 50% and focal in 50%. We observed that renal dysfunction was predominantly a direct effect, that is, lymphomatous invasion. 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| ispartof | Indian journal of nephrology, 2015-07, Vol.25 (4), p.201-205 |
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| source | Medknow Open Access Medical Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Complications and side effects Forecasts and trends Kidney diseases Lymphatic diseases Medical statistics Original Risk factors |
| title | Spectrum of renal involvement in hematolymphoid neoplasms: Renal biopsy findings of 12 cases |
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