A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging

Werner syndrome (WS) is a premature aging disorder caused by WRN protein deficiency. Here, we report on the generation of a human WS model in human embryonic stem cells (ESCs). Differentiation of WRN-null ESCs to mesenchymal stem cells (MSCs) recapitulates features of premature cellular aging, a glo...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2015-06, Vol.348 (6239), p.1160-1163
Hauptverfasser:	Zhang, Weiqi, Li, Jingyi, Suzuki, Keiichiro, Qu, Jing, Wang, Ping, Zhou, Junzhi, Liu, Xiaomeng, Ren, Ruotong, Xu, Xiuling, Ocampo, Alejandro, Yuan, Tingting, Yang, Jiping, Li, Ying, Shi, Liang, Guan, Dee, Pan, Huize, Duan, Shunlei, Ding, Zhichao, Li, Mo, Yi, Fei, Bai, Ruijun, Wang, Yayu, Chen, Chang, Yang, Fuquan, Li, Xiaoyu, Wang, Zimei, Aizawa, Emi, Goebl, April, Soligalla, Rupa Devi, Reddy, Pradeep, Esteban, Concepcion Rodriguez, Tang, Fuchou, Liu, Guang-Hui, Belmonte, Juan Carlos Izpisua
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Alterations Anchoring Cellular Chromatin Determinants Disorders Genetic disorders Individualized Instruction Maintenance Proteins Stem cells
Online-Zugang:	Volltext
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