Autoimmunity-associated protein tyrosine phosphatase PEP negatively regulates IFN-α receptor signaling

The protein tyrosine phosphatase PTPN22(C1858T) allelic polymorphism is associated with increased susceptibility for development of systemic lupus erythematosus (SLE) and other autoimmune diseases. PTPN22 (also known as LYP) and its mouse orthologue PEP play important roles in antigen and Toll-like...

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Veröffentlicht in:	The Journal of experimental medicine 2015-06, Vol.212 (7), p.1081-1093
Hauptverfasser:	Holmes, Derek A, Suto, Eric, Lee, Wyne P, Ou, Qinglin, Gong, Qian, Smith, Hamish R C, Caplazi, Patrick, Chan, Andrew C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western Enzyme-Linked Immunosorbent Assay Flow Cytometry Hematopoietic Stem Cells - metabolism Immunoprecipitation Interferon-alpha - blood Lupus Erythematosus, Systemic - enzymology Mice Mice, Knockout Protein Tyrosine Phosphatase, Non-Receptor Type 22 - genetics Protein Tyrosine Phosphatase, Non-Receptor Type 22 - metabolism Receptor, Interferon alpha-beta - metabolism Signal Transduction - physiology
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