Tocopherols inhibit oxidative and nitrosative stress in estrogen-induced early mammary hyperplasia in ACI rats

Oxidative stress is known to play a key role in estrogen‐induced breast cancer. This study assessed the chemopreventive activity of the naturally occurring γ‐tocopherol‐rich mixture of tocopherols (γ‐TmT) in early stages of estrogen‐induced mammary hyperplasia in ACI rats. ACI rats provide an establ...

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Veröffentlicht in:	Molecular carcinogenesis 2015-09, Vol.54 (9), p.916-925
Hauptverfasser:	Das Gupta, Soumyasri, So, Jae Young, Wall, Brian, Wahler, Joseph, Smolarek, Amanda K., Sae-tan, Sudathip, Soewono, Kelvin Y., Yu, Haixiang, Lee, Mao-Jung, Thomas, Paul E., Yang, Chung S., Suh, Nanjoo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants - therapeutic use Breast cancer Breast Diseases - chemically induced Breast Diseases - diet therapy Breast Diseases - metabolism Breast Diseases - pathology Dietary Supplements - analysis estrogen Estrogens Female Humans Hyperplasia - chemically induced Hyperplasia - diet therapy Hyperplasia - metabolism Hyperplasia - pathology Mammary Glands, Animal - metabolism Mammary Glands, Animal - pathology NF-E2-Related Factor 2 - genetics Oxidative stress Oxidative Stress - drug effects Rats Rats, Inbred ACI RNA, Messenger - genetics Rodents Tocopherols - therapeutic use Tyrosine - analogs & derivatives Tyrosine - analysis Up-Regulation Vitamin E
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