Reduced activity of SKCa and Na‐K ATPase underlies the accelerated impairment of EDH‐type relaxations in mesenteric arteries of aging spontaneously hypertensive rats

Aging is accompanied by endothelial dysfunction due to reduced bioavailability of nitric oxide (NO) and/or reduced endothelium‐dependent hyperpolarizations (EDH). This study examines the hypothesis that hypertension aggravates the impairment of EDH‐type relaxation due to aging. EDH‐type relaxations...

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Veröffentlicht in:	Pharmacology research & perspectives 2015-06, Vol.3 (3), p.n/a
Hauptverfasser:	Kong, Billy W. C., Man, Ricky Y. K., Gao, Yuansheng, Vanhoutte, Paul M., Leung, Susan W. S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging endothelial dysfunction endothelium‐derived hyperpolarization hypertension Original small‐conductance calcium‐activated potassium channel sodium–potassium ATPase
Online-Zugang:	Volltext
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