Maternal Blood Manganese and Early Neurodevelopment: The Mothers and Children's Environmental Health (MOCEH) Study
Manganese is an essential trace element and common component of water, soil, and air. Prenatal manganese exposure may affect fetal and infantile neurodevelopment, but reports on in utero manganese exposure and infant neurodevelopment are rare. This study was conducted to investigate a relationship b...
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| Veröffentlicht in: | Environmental health perspectives 2015-07, Vol.123 (7), p.717-717 |
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| creator | Chung, Soo Eun Cheong, Hae-Kwan Ha, Eun-Hee Kim, Boong-Nyun Ha, Mina Kim, Yangho Hong, Yun-Chul Park, Hyesook Oh, Se-Young |
| description | Manganese is an essential trace element and common component of water, soil, and air. Prenatal manganese exposure may affect fetal and infantile neurodevelopment, but reports on in utero manganese exposure and infant neurodevelopment are rare.
This study was conducted to investigate a relationship between maternal blood manganese level and neurodevelopment of infants at 6 months of age.
Data were obtained from the Mothers and Children's Environmental Health (MOCEH) birth cohort study. The study population included 232 pairs of pregnant women and their infants at 6 months of age. Maternal blood manganese was measured at term, just before delivery. Mental and psychomotor development in infancy was assessed at 6 months of age using the Bayley Scales of Infant Development. The relationship between maternal blood manganese level and the mental and psychomotor development indexes (MDI and PDI) was estimated for manganese modeled as a linear and as a categorical variable and using penalized splines for nonlinear modeling.
Mean ± SD maternal blood manganese concentration was 22.5 ± 6.5 μg/L. After adjustment for potential confounders, blood manganese was used as a continuous variable in a linear and nonlinear model. Associations between maternal blood manganese and MDI and PDI scores followed an inverted U-shape dose-response curve after adjustment for potential confounders, with lower scores associated with both low and high blood concentrations [MDI: likelihood-ratio test (LRT) p = 0.075, PDI: LRT p = 0.038]. Associations of both outcomes with increasing blood manganese shifted from positive to negative at concentrations of 24-28 μg/L in this cohort of term, normal birth weight children.
Although no cut-off point has been established to define manganese toxicity, both high and low blood manganese levels may be associated with neurobehavioral function in infants. |
| doi_str_mv | 10.1289/ehp.1307865 |
| format | Article |
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This study was conducted to investigate a relationship between maternal blood manganese level and neurodevelopment of infants at 6 months of age.
Data were obtained from the Mothers and Children's Environmental Health (MOCEH) birth cohort study. The study population included 232 pairs of pregnant women and their infants at 6 months of age. Maternal blood manganese was measured at term, just before delivery. Mental and psychomotor development in infancy was assessed at 6 months of age using the Bayley Scales of Infant Development. The relationship between maternal blood manganese level and the mental and psychomotor development indexes (MDI and PDI) was estimated for manganese modeled as a linear and as a categorical variable and using penalized splines for nonlinear modeling.
Mean ± SD maternal blood manganese concentration was 22.5 ± 6.5 μg/L. After adjustment for potential confounders, blood manganese was used as a continuous variable in a linear and nonlinear model. Associations between maternal blood manganese and MDI and PDI scores followed an inverted U-shape dose-response curve after adjustment for potential confounders, with lower scores associated with both low and high blood concentrations [MDI: likelihood-ratio test (LRT) p = 0.075, PDI: LRT p = 0.038]. Associations of both outcomes with increasing blood manganese shifted from positive to negative at concentrations of 24-28 μg/L in this cohort of term, normal birth weight children.
Although no cut-off point has been established to define manganese toxicity, both high and low blood manganese levels may be associated with neurobehavioral function in infants.</description><identifier>ISSN: 0091-6765</identifier><identifier>EISSN: 1552-9924</identifier><identifier>DOI: 10.1289/ehp.1307865</identifier><identifier>PMID: 25734517</identifier><language>eng</language><publisher>United States: National Institute of Environmental Health Sciences</publisher><subject>Adult ; Age ; Babies ; Birth weight ; Blood ; Child Development ; Children ; Children & youth ; Children's Health ; Cohort analysis ; Cohort Studies ; Environmental health ; Environmental Pollutants - blood ; Environmental Pollutants - toxicity ; Families & family life ; Female ; Health ; Hospitals ; Humans ; Infant ; Infants ; Male ; Manganese ; Manganese - blood ; Manganese - deficiency ; Manganese - toxicity ; Maternal Exposure - adverse effects ; Maternal-Fetal Exchange ; Mathematical models ; MDI ; Medical records ; Metabolism ; Mothers ; Multivariate Analysis ; Neuropsychological Tests ; Neurotoxicity ; Pregnancy ; Prenatal development ; Prenatal Exposure Delayed Effects ; Quality control ; Questionnaires ; Socioeconomic factors ; Studies ; Trace elements ; Womens health</subject><ispartof>Environmental health perspectives, 2015-07, Vol.123 (7), p.717-717</ispartof><rights>Copyright National Institute of Environmental Health Sciences Jul 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c541t-4bcd863d3813a66b9dbed4461c05f03e201d41d132272acc296bff3aba5033ed3</citedby><cites>FETCH-LOGICAL-c541t-4bcd863d3813a66b9dbed4461c05f03e201d41d132272acc296bff3aba5033ed3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492260/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492260/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25734517$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chung, Soo Eun</creatorcontrib><creatorcontrib>Cheong, Hae-Kwan</creatorcontrib><creatorcontrib>Ha, Eun-Hee</creatorcontrib><creatorcontrib>Kim, Boong-Nyun</creatorcontrib><creatorcontrib>Ha, Mina</creatorcontrib><creatorcontrib>Kim, Yangho</creatorcontrib><creatorcontrib>Hong, Yun-Chul</creatorcontrib><creatorcontrib>Park, Hyesook</creatorcontrib><creatorcontrib>Oh, Se-Young</creatorcontrib><title>Maternal Blood Manganese and Early Neurodevelopment: The Mothers and Children's Environmental Health (MOCEH) Study</title><title>Environmental health perspectives</title><addtitle>Environ Health Perspect</addtitle><description>Manganese is an essential trace element and common component of water, soil, and air. Prenatal manganese exposure may affect fetal and infantile neurodevelopment, but reports on in utero manganese exposure and infant neurodevelopment are rare.
This study was conducted to investigate a relationship between maternal blood manganese level and neurodevelopment of infants at 6 months of age.
Data were obtained from the Mothers and Children's Environmental Health (MOCEH) birth cohort study. The study population included 232 pairs of pregnant women and their infants at 6 months of age. Maternal blood manganese was measured at term, just before delivery. Mental and psychomotor development in infancy was assessed at 6 months of age using the Bayley Scales of Infant Development. The relationship between maternal blood manganese level and the mental and psychomotor development indexes (MDI and PDI) was estimated for manganese modeled as a linear and as a categorical variable and using penalized splines for nonlinear modeling.
Mean ± SD maternal blood manganese concentration was 22.5 ± 6.5 μg/L. After adjustment for potential confounders, blood manganese was used as a continuous variable in a linear and nonlinear model. Associations between maternal blood manganese and MDI and PDI scores followed an inverted U-shape dose-response curve after adjustment for potential confounders, with lower scores associated with both low and high blood concentrations [MDI: likelihood-ratio test (LRT) p = 0.075, PDI: LRT p = 0.038]. Associations of both outcomes with increasing blood manganese shifted from positive to negative at concentrations of 24-28 μg/L in this cohort of term, normal birth weight children.
Although no cut-off point has been established to define manganese toxicity, both high and low blood manganese levels may be associated with neurobehavioral function in infants.</description><subject>Adult</subject><subject>Age</subject><subject>Babies</subject><subject>Birth weight</subject><subject>Blood</subject><subject>Child Development</subject><subject>Children</subject><subject>Children & youth</subject><subject>Children's Health</subject><subject>Cohort analysis</subject><subject>Cohort Studies</subject><subject>Environmental health</subject><subject>Environmental Pollutants - blood</subject><subject>Environmental Pollutants - toxicity</subject><subject>Families & family life</subject><subject>Female</subject><subject>Health</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Infant</subject><subject>Infants</subject><subject>Male</subject><subject>Manganese</subject><subject>Manganese - blood</subject><subject>Manganese - deficiency</subject><subject>Manganese - toxicity</subject><subject>Maternal Exposure - adverse effects</subject><subject>Maternal-Fetal Exchange</subject><subject>Mathematical models</subject><subject>MDI</subject><subject>Medical records</subject><subject>Metabolism</subject><subject>Mothers</subject><subject>Multivariate Analysis</subject><subject>Neuropsychological Tests</subject><subject>Neurotoxicity</subject><subject>Pregnancy</subject><subject>Prenatal development</subject><subject>Prenatal Exposure Delayed Effects</subject><subject>Quality control</subject><subject>Questionnaires</subject><subject>Socioeconomic factors</subject><subject>Studies</subject><subject>Trace elements</subject><subject>Womens 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Blood Manganese and Early Neurodevelopment: The Mothers and Children's Environmental Health (MOCEH) Study</title><author>Chung, Soo Eun ; Cheong, Hae-Kwan ; Ha, Eun-Hee ; Kim, Boong-Nyun ; Ha, Mina ; Kim, Yangho ; Hong, Yun-Chul ; Park, Hyesook ; Oh, Se-Young</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c541t-4bcd863d3813a66b9dbed4461c05f03e201d41d132272acc296bff3aba5033ed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Age</topic><topic>Babies</topic><topic>Birth weight</topic><topic>Blood</topic><topic>Child Development</topic><topic>Children</topic><topic>Children & youth</topic><topic>Children's Health</topic><topic>Cohort analysis</topic><topic>Cohort Studies</topic><topic>Environmental health</topic><topic>Environmental Pollutants - blood</topic><topic>Environmental Pollutants - toxicity</topic><topic>Families & family life</topic><topic>Female</topic><topic>Health</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Infant</topic><topic>Infants</topic><topic>Male</topic><topic>Manganese</topic><topic>Manganese - blood</topic><topic>Manganese - deficiency</topic><topic>Manganese - toxicity</topic><topic>Maternal Exposure - adverse effects</topic><topic>Maternal-Fetal Exchange</topic><topic>Mathematical models</topic><topic>MDI</topic><topic>Medical records</topic><topic>Metabolism</topic><topic>Mothers</topic><topic>Multivariate Analysis</topic><topic>Neuropsychological Tests</topic><topic>Neurotoxicity</topic><topic>Pregnancy</topic><topic>Prenatal development</topic><topic>Prenatal Exposure Delayed Effects</topic><topic>Quality control</topic><topic>Questionnaires</topic><topic>Socioeconomic factors</topic><topic>Studies</topic><topic>Trace elements</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chung, Soo 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titles)</collection><jtitle>Environmental health perspectives</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chung, Soo Eun</au><au>Cheong, Hae-Kwan</au><au>Ha, Eun-Hee</au><au>Kim, Boong-Nyun</au><au>Ha, Mina</au><au>Kim, Yangho</au><au>Hong, Yun-Chul</au><au>Park, Hyesook</au><au>Oh, Se-Young</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Maternal Blood Manganese and Early Neurodevelopment: The Mothers and Children's Environmental Health (MOCEH) Study</atitle><jtitle>Environmental health perspectives</jtitle><addtitle>Environ Health Perspect</addtitle><date>2015-07-01</date><risdate>2015</risdate><volume>123</volume><issue>7</issue><spage>717</spage><epage>717</epage><pages>717-717</pages><issn>0091-6765</issn><eissn>1552-9924</eissn><abstract>Manganese is an essential trace element and common component of water, soil, and air. Prenatal manganese exposure may affect fetal and infantile neurodevelopment, but reports on in utero manganese exposure and infant neurodevelopment are rare.
This study was conducted to investigate a relationship between maternal blood manganese level and neurodevelopment of infants at 6 months of age.
Data were obtained from the Mothers and Children's Environmental Health (MOCEH) birth cohort study. The study population included 232 pairs of pregnant women and their infants at 6 months of age. Maternal blood manganese was measured at term, just before delivery. Mental and psychomotor development in infancy was assessed at 6 months of age using the Bayley Scales of Infant Development. The relationship between maternal blood manganese level and the mental and psychomotor development indexes (MDI and PDI) was estimated for manganese modeled as a linear and as a categorical variable and using penalized splines for nonlinear modeling.
Mean ± SD maternal blood manganese concentration was 22.5 ± 6.5 μg/L. After adjustment for potential confounders, blood manganese was used as a continuous variable in a linear and nonlinear model. Associations between maternal blood manganese and MDI and PDI scores followed an inverted U-shape dose-response curve after adjustment for potential confounders, with lower scores associated with both low and high blood concentrations [MDI: likelihood-ratio test (LRT) p = 0.075, PDI: LRT p = 0.038]. Associations of both outcomes with increasing blood manganese shifted from positive to negative at concentrations of 24-28 μg/L in this cohort of term, normal birth weight children.
Although no cut-off point has been established to define manganese toxicity, both high and low blood manganese levels may be associated with neurobehavioral function in infants.</abstract><cop>United States</cop><pub>National Institute of Environmental Health Sciences</pub><pmid>25734517</pmid><doi>10.1289/ehp.1307865</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0091-6765 |
| ispartof | Environmental health perspectives, 2015-07, Vol.123 (7), p.717-717 |
| issn | 0091-6765 1552-9924 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4492260 |
| source | Jstor Complete Legacy; MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Adult Age Babies Birth weight Blood Child Development Children Children & youth Children's Health Cohort analysis Cohort Studies Environmental health Environmental Pollutants - blood Environmental Pollutants - toxicity Families & family life Female Health Hospitals Humans Infant Infants Male Manganese Manganese - blood Manganese - deficiency Manganese - toxicity Maternal Exposure - adverse effects Maternal-Fetal Exchange Mathematical models MDI Medical records Metabolism Mothers Multivariate Analysis Neuropsychological Tests Neurotoxicity Pregnancy Prenatal development Prenatal Exposure Delayed Effects Quality control Questionnaires Socioeconomic factors Studies Trace elements Womens health |
| title | Maternal Blood Manganese and Early Neurodevelopment: The Mothers and Children's Environmental Health (MOCEH) Study |
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