Effect of Neem oil and Haridra on non-healing wounds
In Ayurveda, Vrana (wound) has stated as tissue destruction and discoloration of viable tissue due to various etiology. In Sushruta Samhita, Sushruta described Vrana as a main subject. Most commonly Vrana can be classified into Shuddha and Dushta Vrana (chronic wound/nonhealing ulcers). Among the va...
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| Veröffentlicht in: | Ayu 2014-10, Vol.35 (4), p.398-403 |
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| creator | Singh, Anjali Singh, Anil Kumar Narayan, G Singh, Teja B Shukla, Vijay Kumar |
| description | In Ayurveda, Vrana (wound) has stated as tissue destruction and discoloration of viable tissue due to various etiology. In Sushruta Samhita, Sushruta described Vrana as a main subject. Most commonly Vrana can be classified into Shuddha and Dushta Vrana (chronic wound/nonhealing ulcers). Among the various drugs mentioned for Dushta Vrana, two of them, Neem (Azadirechta indica A. Juss) oil and Haridra (Curcuma longa Linn.) powder are selected for their wide spectrum action on wound.
To compare the effect of Neem oil and Haridra in the treatment of chronic non-healing wounds.
Total 60 patients of wounds with more than 6 weeks duration were enrolled and alternatively allocated to Group I (topical application of Neem oil), Group II (Haridra powder capsules, 1 g 3 times orally) and Group III (both drugs). Duration of treatment was considered until complete healing of the wound, whereas 4(th) and 8(th) week were considered for assessment of 50% healing. Wound size was measured and recorded at weekly intervals. Wound biopsy was repeated after 4 weeks for assessment of angiogenesis and deoxyribonucleic acid (DNA) analysis.
After 8 weeks of treatment, 50% wound healing was observed in 43.80% patients of Group I, 18.20% patients of Group II, and 70.00% patients of Group III. Microscopic angiogenesis grading system scores and DNA concentration showed highly significant effect of combined use of both drugs when compared before and after results of treatment (P < 0.001).
Topical use of Neem oil and oral use of Haridra powder capsule used in combination were found effective for chronic non-healing wounds. |
| doi_str_mv | 10.4103/0974-8520.158998 |
| format | Article |
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To compare the effect of Neem oil and Haridra in the treatment of chronic non-healing wounds.
Total 60 patients of wounds with more than 6 weeks duration were enrolled and alternatively allocated to Group I (topical application of Neem oil), Group II (Haridra powder capsules, 1 g 3 times orally) and Group III (both drugs). Duration of treatment was considered until complete healing of the wound, whereas 4(th) and 8(th) week were considered for assessment of 50% healing. Wound size was measured and recorded at weekly intervals. Wound biopsy was repeated after 4 weeks for assessment of angiogenesis and deoxyribonucleic acid (DNA) analysis.
After 8 weeks of treatment, 50% wound healing was observed in 43.80% patients of Group I, 18.20% patients of Group II, and 70.00% patients of Group III. Microscopic angiogenesis grading system scores and DNA concentration showed highly significant effect of combined use of both drugs when compared before and after results of treatment (P < 0.001).
Topical use of Neem oil and oral use of Haridra powder capsule used in combination were found effective for chronic non-healing wounds.</description><identifier>ISSN: 0974-8520</identifier><identifier>EISSN: 0976-9382</identifier><identifier>DOI: 10.4103/0974-8520.158998</identifier><identifier>PMID: 26195902</identifier><language>eng</language><publisher>India: Medknow Publications and Media Pvt. Ltd</publisher><subject>Angiogenesis ; Antibiotics ; Ayurvedic medicine ; Cellular biology ; Clinical Research ; Deoxyribonucleic acid ; Diabetes ; DNA ; Drugs ; Leprosy ; Medical research ; Methods ; Statistical analysis ; Sulfur ; Wound healing</subject><ispartof>Ayu, 2014-10, Vol.35 (4), p.398-403</ispartof><rights>COPYRIGHT 2014 Medknow Publications and Media Pvt. Ltd.</rights><rights>Copyright Medknow Publications & Media Pvt Ltd Oct-Dec 2014</rights><rights>Copyright: © AYU (An International Quarterly Journal of Research in Ayurveda) 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3368-760576fb240411475679e7aa80b0feaf0f7607c6b695dac1ea280503af5856b23</citedby><cites>FETCH-LOGICAL-c3368-760576fb240411475679e7aa80b0feaf0f7607c6b695dac1ea280503af5856b23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492024/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492024/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26195902$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Singh, Anjali</creatorcontrib><creatorcontrib>Singh, Anil Kumar</creatorcontrib><creatorcontrib>Narayan, G</creatorcontrib><creatorcontrib>Singh, Teja B</creatorcontrib><creatorcontrib>Shukla, Vijay Kumar</creatorcontrib><title>Effect of Neem oil and Haridra on non-healing wounds</title><title>Ayu</title><addtitle>Ayu</addtitle><description>In Ayurveda, Vrana (wound) has stated as tissue destruction and discoloration of viable tissue due to various etiology. In Sushruta Samhita, Sushruta described Vrana as a main subject. Most commonly Vrana can be classified into Shuddha and Dushta Vrana (chronic wound/nonhealing ulcers). Among the various drugs mentioned for Dushta Vrana, two of them, Neem (Azadirechta indica A. Juss) oil and Haridra (Curcuma longa Linn.) powder are selected for their wide spectrum action on wound.
To compare the effect of Neem oil and Haridra in the treatment of chronic non-healing wounds.
Total 60 patients of wounds with more than 6 weeks duration were enrolled and alternatively allocated to Group I (topical application of Neem oil), Group II (Haridra powder capsules, 1 g 3 times orally) and Group III (both drugs). Duration of treatment was considered until complete healing of the wound, whereas 4(th) and 8(th) week were considered for assessment of 50% healing. Wound size was measured and recorded at weekly intervals. Wound biopsy was repeated after 4 weeks for assessment of angiogenesis and deoxyribonucleic acid (DNA) analysis.
After 8 weeks of treatment, 50% wound healing was observed in 43.80% patients of Group I, 18.20% patients of Group II, and 70.00% patients of Group III. Microscopic angiogenesis grading system scores and DNA concentration showed highly significant effect of combined use of both drugs when compared before and after results of treatment (P < 0.001).
Topical use of Neem oil and oral use of Haridra powder capsule used in combination were found effective for chronic non-healing wounds.</description><subject>Angiogenesis</subject><subject>Antibiotics</subject><subject>Ayurvedic medicine</subject><subject>Cellular biology</subject><subject>Clinical Research</subject><subject>Deoxyribonucleic acid</subject><subject>Diabetes</subject><subject>DNA</subject><subject>Drugs</subject><subject>Leprosy</subject><subject>Medical research</subject><subject>Methods</subject><subject>Statistical analysis</subject><subject>Sulfur</subject><subject>Wound healing</subject><issn>0974-8520</issn><issn>0976-9382</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNptkc1PHSEUxUnTRo26d9VM0k0383r5hk0TY7Q2MXXTrgnDwBMzAxbe1Pjfy_NZW5vCAnLv7xxyOQidYFgxDPQTaMl6xQmsMFdaqzfooJVEr6kib5_uu_Y-Oq71FtpiGpSSe2ifCKy5BnKA2HkI3m26HLpv3s9djlNn09hd2hLHYrucupRTf-PtFNO6u89LGusRehfsVP3x83mIflycfz-77K-uv3w9O73qHaVC9VIAlyIMhAHDmEkupPbSWgUDBG8DhEZIJwah-Wgd9pYo4EBt4IqLgdBD9Hnne7cMsx-dT5tiJ3NX4mzLg8k2mtedFG_MOv8yjGkChDWDj88GJf9cfN2YOVbnp8kmn5dqsNAKKChKG_rhH_Q2LyW18QyWWAIRgos_1NpO3sQUcnvXbU3NKcOaSuBcNWr1H6rt0c_R5eRDbPVXAtgJXMm1Fh9eZsRgtmGbbZpmm6bZhd0k7__-mxfB72jpIwDroAk</recordid><startdate>201410</startdate><enddate>201410</enddate><creator>Singh, Anjali</creator><creator>Singh, Anil Kumar</creator><creator>Narayan, G</creator><creator>Singh, Teja B</creator><creator>Shukla, Vijay Kumar</creator><general>Medknow Publications and Media Pvt. 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In Sushruta Samhita, Sushruta described Vrana as a main subject. Most commonly Vrana can be classified into Shuddha and Dushta Vrana (chronic wound/nonhealing ulcers). Among the various drugs mentioned for Dushta Vrana, two of them, Neem (Azadirechta indica A. Juss) oil and Haridra (Curcuma longa Linn.) powder are selected for their wide spectrum action on wound.
To compare the effect of Neem oil and Haridra in the treatment of chronic non-healing wounds.
Total 60 patients of wounds with more than 6 weeks duration were enrolled and alternatively allocated to Group I (topical application of Neem oil), Group II (Haridra powder capsules, 1 g 3 times orally) and Group III (both drugs). Duration of treatment was considered until complete healing of the wound, whereas 4(th) and 8(th) week were considered for assessment of 50% healing. Wound size was measured and recorded at weekly intervals. Wound biopsy was repeated after 4 weeks for assessment of angiogenesis and deoxyribonucleic acid (DNA) analysis.
After 8 weeks of treatment, 50% wound healing was observed in 43.80% patients of Group I, 18.20% patients of Group II, and 70.00% patients of Group III. Microscopic angiogenesis grading system scores and DNA concentration showed highly significant effect of combined use of both drugs when compared before and after results of treatment (P < 0.001).
Topical use of Neem oil and oral use of Haridra powder capsule used in combination were found effective for chronic non-healing wounds.</abstract><cop>India</cop><pub>Medknow Publications and Media Pvt. Ltd</pub><pmid>26195902</pmid><doi>10.4103/0974-8520.158998</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Angiogenesis Antibiotics Ayurvedic medicine Cellular biology Clinical Research Deoxyribonucleic acid Diabetes DNA Drugs Leprosy Medical research Methods Statistical analysis Sulfur Wound healing |
| title | Effect of Neem oil and Haridra on non-healing wounds |
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