Thymus-derived regulatory T cells restrain pro-inflammatory Th1 responses by downregulating CD70 on dendritic cells

The severity and intensity of autoimmune disease in immune dysregulation, polyendocrinopathy, enteropathy, X‐linked (IPEX) patients and in scurfy mice emphasize the critical role played by thymus‐derived regulatory T cells (tTregs) in maintaining peripheral immune tolerance. However, although tTregs...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The EMBO journal 2015-05, Vol.34 (10), p.1336-1348
Hauptverfasser:	Dhainaut, Maxime, Coquerelle, Caroline, Uzureau, Sophie, Denoeud, Julie, Acolty, Valérie, Oldenhove, Guillaume, Galuppo, Adrien, Sparwasser, Tim, Thielemans, Kris, Pays, Etienne, Yagita, Hideo, Borst, Jannie, Moser, Muriel
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoimmune diseases CD27 Ligand - genetics CD27 Ligand - metabolism Cellular biology costimulation dendritic cells Dendritic Cells - metabolism EMBO19 Immune system Immunization inflammation Mice Mice, Inbred BALB C Mice, Inbred C57BL Reverse Transcriptase Polymerase Chain Reaction suppression T cell receptors T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism Th1 Cells - immunology Th1 Cells - metabolism Thymus Gland - immunology Thymus Gland - metabolism trogocytosis Tumor Necrosis Factor Receptor Superfamily, Member 7 - genetics Tumor Necrosis Factor Receptor Superfamily, Member 7 - metabolism
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!