NTS adenosine A2a receptors inhibit the cardiopulmonary chemoreflex control of regional sympathetic outputs via a GABAergic mechanism

Adenosine is a powerful central neuromodulator acting via opposing A1 (inhibitor) and A2a (activator) receptors. However, in the nucleus of the solitary tract (NTS), both adenosine receptor subtypes attenuate cardiopulmonary chemoreflex (CCR) sympathoinhibition of renal, adrenal, and lumbar sympathe...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 2015-07, Vol.309 (1), p.H185-H197
Hauptverfasser:	Minic, Zeljka, O'Leary, Donal S, Scislo, Tadeusz J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine - analogs & derivatives Adenosine - pharmacology Adenosine A2 Receptor Agonists - pharmacology Animals Bicuculline - pharmacology Biguanides - pharmacology Cardiovascular Neurohormonal Regulation GABA Antagonists - pharmacology Heart - drug effects Microinjections Morpholines - pharmacology Phenethylamines - pharmacology Rats Receptor, Adenosine A2A - metabolism Receptors, GABA-A - metabolism Receptors, GABA-B - metabolism Reflex - drug effects Reflex - physiology Serotonin Receptor Agonists - pharmacology Solitary Nucleus - metabolism Sympathetic Nervous System - drug effects Sympathetic Nervous System - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!