TLR2 and TLR9 contribute to alcohol-mediated liver injury through induction of CXCL1 and neutrophil infiltration

Although previous studies reported the involvement of the TLR4-TRIF pathway in alcohol-induced liver injury, the role of TLR2 and TLR9 signaling in alcohol-mediated neutrophil infiltration and liver injury has not been elucidated. Since alcohol binge drinking is recognized to induce more severe form...

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Veröffentlicht in:	American journal of physiology: Gastrointestinal and liver physiology 2015-07, Vol.309 (1), p.G30-G41
Hauptverfasser:	Roh, Yoon Seok, Zhang, Bi, Loomba, Rohit, Seki, Ekihiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binge Drinking Cells, Cultured Chemokine CXCL1 - immunology Chemokine CXCL1 - metabolism Disease Models, Animal Drunkenness Ethanol Female Hepatic Stellate Cells - immunology Hepatic Stellate Cells - metabolism Hepatitis Hepatocytes - immunology Hepatocytes - metabolism Hepatology Kupffer Cells - immunology Kupffer Cells - metabolism Leukocytes Liver - immunology Liver - metabolism Liver - pathology Liver and Biliary Tract Liver diseases Liver Diseases, Alcoholic - genetics Liver Diseases, Alcoholic - immunology Liver Diseases, Alcoholic - metabolism Liver Diseases, Alcoholic - pathology Liver Diseases, Alcoholic - prevention & control Mice, Inbred C57BL Mice, Knockout Myeloid Differentiation Factor 88 - metabolism Neutrophil Infiltration Receptors, Interleukin-8B - immunology Receptors, Interleukin-8B - metabolism Rodents Signal Transduction Time Factors Toll-Like Receptor 2 - deficiency Toll-Like Receptor 2 - genetics Toll-Like Receptor 2 - metabolism Toll-Like Receptor 9 - deficiency Toll-Like Receptor 9 - genetics Toll-Like Receptor 9 - metabolism Up-Regulation
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