Melatonin Attenuates Oxidative Damage Induced by Acrylamide In Vitro and In Vivo

Acrylamide (ACR) has been classified as a neurotoxic agent in animals and humans. Melatonin (MT) has been shown to be potentially effective in preventing oxidative stress related neurodegenerative disorders. In this study, whether MT exerted a protective effect against ACR-induced oxidative damage w...

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Veröffentlicht in:	Oxidative medicine and cellular longevity 2015-01, Vol.2015 (2015), p.1-12
Hauptverfasser:	Lu, Qing, Wang, Dun, Lu, Huiping, Zhu, Lanlan, Pan, Xiaoqi, Yan, Hong
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylamide - toxicity Alzheimer's disease Animals Antioxidants Brain - drug effects Brain - metabolism Brain - pathology Cell Survival - drug effects Degeneration Deoxyribonucleic acid Disease control Disease prevention DNA DNA damage DNA Damage - drug effects Enzymes Free radicals Glutathione - metabolism Glutathione Peroxidase - metabolism Health aspects Laboratory animals Lipid Peroxidation - drug effects Male Malondialdehyde - metabolism Melatonin Melatonin - pharmacology Nervous system Neurotoxicity Oxidative stress Oxidative Stress - drug effects PC12 Cells Polyphenols Public health Rats Rats, Sprague-Dawley Reactive Oxygen Species - metabolism Rodents Science Studies Superoxide Dismutase - metabolism
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