Development of glandular models from human nasal progenitor cells

Hyperplasia/hypertrophy of submucosal glands contributes to mucus overproduction in chronic diseases of the upper and lower respiratory tracts, especially in adult and pediatric chronic rhinosinusitis. Mechanisms that lead to glandular hyperplasia/hypertrophy are markedly understudied, reflecting a...

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Veröffentlicht in:	American journal of respiratory cell and molecular biology 2015-05, Vol.52 (5), p.535-542
Hauptverfasser:	Wu, Xiaofang, Mimms, Remy, Banigan, Maureen, Lee, Michael, Elkis, Viktoria, Peters-Hall, Jennifer R, Mubeen, Humaira, Joselow, Andrew, Peña, Maria T, Rose, Mary C
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Differentiation Cells, Cultured Coculture Techniques Collagen Collagen - metabolism Collagen Type I - metabolism Culture Media, Conditioned - metabolism Drug Combinations Epithelial Cells - metabolism Epithelial Cells - physiology Exocrine Glands - cytology Exocrine Glands - metabolism Exocrine Glands - physiology Extracellular Matrix - metabolism Fibroblasts - metabolism Gels Humans Laminin - metabolism Major Technical Advances Medical research Morphology Nasal Mucosa - cytology Nasal Mucosa - metabolism Nasal Mucosa - physiology Organogenesis Paracrine Communication Pluripotent Stem Cells - metabolism Pluripotent Stem Cells - physiology Proteoglycans - metabolism Rodents Sinuses Stem Cell Niche Tissue Engineering - methods
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