Thrombospondin-1 (TSP1) Contributes to the Development of Vascular Inflammation by Regulating Monocytic Cell Motility in Mouse Models of Abdominal Aortic Aneurysm

RATIONALE:Histological examination of abdominal aortic aneurysm (AAA) tissues demonstrates extracellular matrix destruction and infiltration of inflammatory cells. Previous work with mouse models of AAA has shown that anti-inflammatory strategies can effectively attenuate aneurysm formation. Thrombo...

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Veröffentlicht in:	Circulation research 2015-07, Vol.117 (2), p.129-141
Hauptverfasser:	Liu, Zhenjie, Morgan, Stephanie, Ren, Jun, Wang, Qiwei, Annis, Douglas S, Mosher, Deane F, Zhang, Jing, Sorenson, Christine M, Sheibani, Nader, Liu, Bo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive Transfer Angiotensin II - toxicity Animals Aorta, Abdominal - pathology Aortic Aneurysm, Abdominal - etiology Aortic Aneurysm, Abdominal - metabolism Aortic Aneurysm, Abdominal - physiopathology Aortic Aneurysm, Abdominal - prevention & control Apolipoproteins E - deficiency Bone Marrow Transplantation Calcium Phosphates - toxicity Cell Line Cell Movement Disease Models, Animal Inflammation Macrophages - physiology Macrophages - transplantation Mice Mice, Inbred C57BL Mice, Knockout Monocytes - physiology Monocytes - transplantation Pancreatic Elastase - toxicity Radiation Chimera Recombinant Proteins - therapeutic use Thrombospondin 1 - biosynthesis Thrombospondin 1 - deficiency Thrombospondin 1 - physiology Thrombospondin 1 - therapeutic use Up-Regulation
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