Interferon-β Mediates Signaling Pathways Uniquely Regulated in Hepatic Stellate Cells and Attenuates the Progression of Hepatic Fibrosis in a Dietary Mouse Model

The results of clinical and experimental studies suggest that type I interferons (IFNs) may have direct antifibrotic activity in addition to their antiviral properties. However, the mechanisms are still unclear; in particular, little is known about the antifibrotic activity of IFN-β and how its acti...

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Veröffentlicht in:	Journal of interferon & cytokine research 2015-06, Vol.35 (6), p.464-473
Hauptverfasser:	Shimozono, Rieko, Nishimura, Kazumi, Akiyama, Hideo, Funamoto, Saeko, Izawa, Akiko, Sai, Takafumi, Kunita, Kana, Kainoh, Mie, Suzuki, Tomohiko, Kawada, Norifumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Cycle - drug effects Choline - metabolism Choline Deficiency - drug therapy Choline Deficiency - metabolism Choline Deficiency - pathology Disease Models, Animal Disease Progression Food, Formulated Gene Expression Regulation Hepatic Stellate Cells - drug effects Hepatic Stellate Cells - metabolism Hepatic Stellate Cells - pathology Humans Interferon-alpha - metabolism Interferon-alpha - pharmacology Interferon-beta - metabolism Interferon-beta - pharmacology Liver - drug effects Liver - metabolism Liver - pathology Liver Cirrhosis - drug therapy Liver Cirrhosis - etiology Liver Cirrhosis - metabolism Liver Cirrhosis - pathology Male Mice Mice, Inbred C57BL Myeloid Differentiation Factor 88 - genetics Myeloid Differentiation Factor 88 - metabolism Oligonucleotide Array Sequence Analysis Research Reports Signal Transduction Toll-Like Receptor 4 - genetics Toll-Like Receptor 4 - metabolism
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