Neutrophil CD64 expression as a diagnostic marker for sepsis in adult patients: a meta-analysis
Neutrophil CD64 (nCD64) expression appears to be a promising marker of bacterial infections. The aim of this meta-analysis was to assess the accuracy of nCD64 expression for the diagnosis of sepsis in critically ill adult patients. We systematically searched PubMed, Embase, ISI Web of Knowledge, and...
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| Veröffentlicht in: | Critical care (London, England) England), 2015-06, Vol.19 (1), p.245-245, Article 245 |
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| creator | Wang, Xiao Li, Zhong-Yun Zeng, Ling Zhang, An-Qiang Pan, Wei Gu, Wei Jiang, Jian-Xin |
| description | Neutrophil CD64 (nCD64) expression appears to be a promising marker of bacterial infections. The aim of this meta-analysis was to assess the accuracy of nCD64 expression for the diagnosis of sepsis in critically ill adult patients.
We systematically searched PubMed, Embase, ISI Web of Knowledge, and the Cochrane Library for literature published between database inception and 19 May 2014, as well as reference lists of identified primary studies. Studies were included if they included assessment of the accuracy of nCD64 expression for sepsis diagnosis in adult patients and provided sufficient information to construct a 2×2 contingency table.
A total of 8 studies comprising 1986 patients fulfilled the inclusion criteria for the final analysis. The pooled sensitivity and specificity were 0.76 (95 % confidence interval [CI], 0.73-0.78) and 0.85 (95 % CI, 0.82-0.87), respectively. The positive likelihood ratio, negative likelihood ratio and diagnostic odds ratio were 8.15 (95 % CI, 3.82-17.36), 0.16 (95 % CI, 0.09-0.30), and 60.41 (95 % CI, 15.87-229.90), respectively. The area under the summary receiver operating characteristic curve of nCD64 expression with Q* value were 0.95 (Q* =0.89).
On the basis of our meta-analysis, nCD64 expression is a helpful marker for early diagnosis of sepsis in critically ill patients. The results of the test should not be used alone to diagnose sepsis, but instead should be interpreted in combination with medical history, physical examination, and other test results. |
| doi_str_mv | 10.1186/s13054-015-0972-z |
| format | Article |
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We systematically searched PubMed, Embase, ISI Web of Knowledge, and the Cochrane Library for literature published between database inception and 19 May 2014, as well as reference lists of identified primary studies. Studies were included if they included assessment of the accuracy of nCD64 expression for sepsis diagnosis in adult patients and provided sufficient information to construct a 2×2 contingency table.
A total of 8 studies comprising 1986 patients fulfilled the inclusion criteria for the final analysis. The pooled sensitivity and specificity were 0.76 (95 % confidence interval [CI], 0.73-0.78) and 0.85 (95 % CI, 0.82-0.87), respectively. The positive likelihood ratio, negative likelihood ratio and diagnostic odds ratio were 8.15 (95 % CI, 3.82-17.36), 0.16 (95 % CI, 0.09-0.30), and 60.41 (95 % CI, 15.87-229.90), respectively. The area under the summary receiver operating characteristic curve of nCD64 expression with Q* value were 0.95 (Q* =0.89).
On the basis of our meta-analysis, nCD64 expression is a helpful marker for early diagnosis of sepsis in critically ill patients. The results of the test should not be used alone to diagnose sepsis, but instead should be interpreted in combination with medical history, physical examination, and other test results.</description><identifier>ISSN: 1364-8535</identifier><identifier>EISSN: 1466-609X</identifier><identifier>EISSN: 1364-8535</identifier><identifier>EISSN: 1366-609X</identifier><identifier>DOI: 10.1186/s13054-015-0972-z</identifier><identifier>PMID: 26059345</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Accuracy ; Adult ; Adults ; Analysis ; Antigens ; Bacterial infections ; Biomarkers ; Biomarkers - blood ; Critical care ; Critical Illness - epidemiology ; Database industry ; Development and progression ; Diagnosis ; Fc receptors ; Flow cytometry ; Gene Expression Regulation ; Genetic aspects ; Health aspects ; Humans ; Infection ; Infections ; Intensive care ; Medical diagnosis ; Medical research ; Medicine, Experimental ; Meta-analysis ; Neutrophils ; Neutrophils - metabolism ; Receptors, IgG - biosynthesis ; Receptors, IgG - blood ; Sepsis ; Sepsis - blood ; Sepsis - diagnosis ; Sepsis - epidemiology ; Viral infections</subject><ispartof>Critical care (London, England), 2015-06, Vol.19 (1), p.245-245, Article 245</ispartof><rights>COPYRIGHT 2015 BioMed Central Ltd.</rights><rights>Copyright BioMed Central 2015</rights><rights>Wang et al. 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c564t-55131acda237c9e6f2cc5f892fd9d03379356de75beef3367bb513837322f7103</citedby><cites>FETCH-LOGICAL-c564t-55131acda237c9e6f2cc5f892fd9d03379356de75beef3367bb513837322f7103</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490738/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490738/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26059345$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Xiao</creatorcontrib><creatorcontrib>Li, Zhong-Yun</creatorcontrib><creatorcontrib>Zeng, Ling</creatorcontrib><creatorcontrib>Zhang, An-Qiang</creatorcontrib><creatorcontrib>Pan, Wei</creatorcontrib><creatorcontrib>Gu, Wei</creatorcontrib><creatorcontrib>Jiang, Jian-Xin</creatorcontrib><title>Neutrophil CD64 expression as a diagnostic marker for sepsis in adult patients: a meta-analysis</title><title>Critical care (London, England)</title><addtitle>Crit Care</addtitle><description>Neutrophil CD64 (nCD64) expression appears to be a promising marker of bacterial infections. The aim of this meta-analysis was to assess the accuracy of nCD64 expression for the diagnosis of sepsis in critically ill adult patients.
We systematically searched PubMed, Embase, ISI Web of Knowledge, and the Cochrane Library for literature published between database inception and 19 May 2014, as well as reference lists of identified primary studies. Studies were included if they included assessment of the accuracy of nCD64 expression for sepsis diagnosis in adult patients and provided sufficient information to construct a 2×2 contingency table.
A total of 8 studies comprising 1986 patients fulfilled the inclusion criteria for the final analysis. The pooled sensitivity and specificity were 0.76 (95 % confidence interval [CI], 0.73-0.78) and 0.85 (95 % CI, 0.82-0.87), respectively. The positive likelihood ratio, negative likelihood ratio and diagnostic odds ratio were 8.15 (95 % CI, 3.82-17.36), 0.16 (95 % CI, 0.09-0.30), and 60.41 (95 % CI, 15.87-229.90), respectively. The area under the summary receiver operating characteristic curve of nCD64 expression with Q* value were 0.95 (Q* =0.89).
On the basis of our meta-analysis, nCD64 expression is a helpful marker for early diagnosis of sepsis in critically ill patients. The results of the test should not be used alone to diagnose sepsis, but instead should be interpreted in combination with medical history, physical examination, and other test results.</description><subject>Accuracy</subject><subject>Adult</subject><subject>Adults</subject><subject>Analysis</subject><subject>Antigens</subject><subject>Bacterial infections</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Critical care</subject><subject>Critical Illness - epidemiology</subject><subject>Database industry</subject><subject>Development and progression</subject><subject>Diagnosis</subject><subject>Fc receptors</subject><subject>Flow cytometry</subject><subject>Gene Expression Regulation</subject><subject>Genetic aspects</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Infection</subject><subject>Infections</subject><subject>Intensive care</subject><subject>Medical diagnosis</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Meta-analysis</subject><subject>Neutrophils</subject><subject>Neutrophils - metabolism</subject><subject>Receptors, IgG - biosynthesis</subject><subject>Receptors, IgG - blood</subject><subject>Sepsis</subject><subject>Sepsis - blood</subject><subject>Sepsis - diagnosis</subject><subject>Sepsis - epidemiology</subject><subject>Viral infections</subject><issn>1364-8535</issn><issn>1466-609X</issn><issn>1364-8535</issn><issn>1366-609X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNptkk9vFSEUxYnR2Pr0A7gxJG66mQoDF2ZcmDTPf02autHEHeExl1fqzDDCjLH99PLyamtNwwICv3PuveQQ8pKzY84b9SZzwUBWjEPFWl1X14_IIZdKVYq13x-Xs1CyakDAAXmW8yVjXDdKPCUHtWLQCgmHxJzjMqc4XYSert8rSfH3lDDnEEdqM7W0C3Y7xjwHRwebfmCiPiaaccoh01CgbulnOtk54Djnt0Ux4GwrO9r-qiDPyRNv-4wvbvYV-fbxw9f15-rsy6fT9clZ5UDJuQLgglvX2Vpo16LytXPgm7b2XdsxIXQrQHWoYYPohVB6symKRmhR115zJlbk3d53WjYDdq40k2xvphRK11cm2mDuv4zhwmzjLyNly3RxWpGjG4MUfy6YZzOE7LDv7YhxyYarFsr3gdYFff0fehmXVAYuVIEAFOfyjtraHk0YfSx13c7UnIDk0EDd7MoeP0CV1eEQXBzRh3J_T8D3Apdizgn97YycmV0qzD4VpqTC7FJhrovm1b-fc6v4GwPxBwY_sgU</recordid><startdate>20150610</startdate><enddate>20150610</enddate><creator>Wang, Xiao</creator><creator>Li, Zhong-Yun</creator><creator>Zeng, Ling</creator><creator>Zhang, An-Qiang</creator><creator>Pan, Wei</creator><creator>Gu, Wei</creator><creator>Jiang, Jian-Xin</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150610</creationdate><title>Neutrophil CD64 expression as a diagnostic marker for sepsis in adult patients: a meta-analysis</title><author>Wang, Xiao ; Li, Zhong-Yun ; Zeng, Ling ; Zhang, An-Qiang ; Pan, Wei ; Gu, Wei ; Jiang, Jian-Xin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c564t-55131acda237c9e6f2cc5f892fd9d03379356de75beef3367bb513837322f7103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Accuracy</topic><topic>Adult</topic><topic>Adults</topic><topic>Analysis</topic><topic>Antigens</topic><topic>Bacterial infections</topic><topic>Biomarkers</topic><topic>Biomarkers - blood</topic><topic>Critical care</topic><topic>Critical Illness - epidemiology</topic><topic>Database industry</topic><topic>Development and progression</topic><topic>Diagnosis</topic><topic>Fc receptors</topic><topic>Flow cytometry</topic><topic>Gene Expression Regulation</topic><topic>Genetic aspects</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Infection</topic><topic>Infections</topic><topic>Intensive care</topic><topic>Medical diagnosis</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Meta-analysis</topic><topic>Neutrophils</topic><topic>Neutrophils - metabolism</topic><topic>Receptors, IgG - biosynthesis</topic><topic>Receptors, IgG - blood</topic><topic>Sepsis</topic><topic>Sepsis - blood</topic><topic>Sepsis - diagnosis</topic><topic>Sepsis - epidemiology</topic><topic>Viral infections</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Xiao</creatorcontrib><creatorcontrib>Li, Zhong-Yun</creatorcontrib><creatorcontrib>Zeng, Ling</creatorcontrib><creatorcontrib>Zhang, An-Qiang</creatorcontrib><creatorcontrib>Pan, Wei</creatorcontrib><creatorcontrib>Gu, Wei</creatorcontrib><creatorcontrib>Jiang, Jian-Xin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Critical care (London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Xiao</au><au>Li, Zhong-Yun</au><au>Zeng, Ling</au><au>Zhang, An-Qiang</au><au>Pan, Wei</au><au>Gu, Wei</au><au>Jiang, Jian-Xin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neutrophil CD64 expression as a diagnostic marker for sepsis in adult patients: a meta-analysis</atitle><jtitle>Critical care (London, England)</jtitle><addtitle>Crit Care</addtitle><date>2015-06-10</date><risdate>2015</risdate><volume>19</volume><issue>1</issue><spage>245</spage><epage>245</epage><pages>245-245</pages><artnum>245</artnum><issn>1364-8535</issn><eissn>1466-609X</eissn><eissn>1364-8535</eissn><eissn>1366-609X</eissn><abstract>Neutrophil CD64 (nCD64) expression appears to be a promising marker of bacterial infections. The aim of this meta-analysis was to assess the accuracy of nCD64 expression for the diagnosis of sepsis in critically ill adult patients.
We systematically searched PubMed, Embase, ISI Web of Knowledge, and the Cochrane Library for literature published between database inception and 19 May 2014, as well as reference lists of identified primary studies. Studies were included if they included assessment of the accuracy of nCD64 expression for sepsis diagnosis in adult patients and provided sufficient information to construct a 2×2 contingency table.
A total of 8 studies comprising 1986 patients fulfilled the inclusion criteria for the final analysis. The pooled sensitivity and specificity were 0.76 (95 % confidence interval [CI], 0.73-0.78) and 0.85 (95 % CI, 0.82-0.87), respectively. The positive likelihood ratio, negative likelihood ratio and diagnostic odds ratio were 8.15 (95 % CI, 3.82-17.36), 0.16 (95 % CI, 0.09-0.30), and 60.41 (95 % CI, 15.87-229.90), respectively. The area under the summary receiver operating characteristic curve of nCD64 expression with Q* value were 0.95 (Q* =0.89).
On the basis of our meta-analysis, nCD64 expression is a helpful marker for early diagnosis of sepsis in critically ill patients. The results of the test should not be used alone to diagnose sepsis, but instead should be interpreted in combination with medical history, physical examination, and other test results.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>26059345</pmid><doi>10.1186/s13054-015-0972-z</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; SpringerLink Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection; Springer Nature OA Free Journals |
| subjects | Accuracy Adult Adults Analysis Antigens Bacterial infections Biomarkers Biomarkers - blood Critical care Critical Illness - epidemiology Database industry Development and progression Diagnosis Fc receptors Flow cytometry Gene Expression Regulation Genetic aspects Health aspects Humans Infection Infections Intensive care Medical diagnosis Medical research Medicine, Experimental Meta-analysis Neutrophils Neutrophils - metabolism Receptors, IgG - biosynthesis Receptors, IgG - blood Sepsis Sepsis - blood Sepsis - diagnosis Sepsis - epidemiology Viral infections |
| title | Neutrophil CD64 expression as a diagnostic marker for sepsis in adult patients: a meta-analysis |
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