Macronutrients and caloric intake in health and longevity
Both lifespan and healthspan are influenced by nutrition, with nutritional interventions proving to be robust across a wide range of species. However, the relationship between nutrition, health and aging is still not fully understood. Caloric restriction is the most studied dietary intervention know...
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| Veröffentlicht in: | Journal of endocrinology 2015-07, Vol.226 (1), p.R17-R28 |
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| container_title | Journal of endocrinology |
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| creator | Solon-Biet, Samantha M Mitchell, Sarah J de Cabo, Rafael Raubenheimer, David Le Couteur, David G Simpson, Stephen J |
| description | Both lifespan and healthspan are influenced by nutrition, with nutritional interventions proving to be robust across a wide range of species. However, the relationship between nutrition, health and aging is still not fully understood. Caloric restriction is the most studied dietary intervention known to extend life in many organisms, but recently the balance of macronutrients has been shown to play a critical role. In this review, we discuss the current understanding regarding the impact of calories and macronutrient balance in mammalian health and longevity, and highlight the key nutrient-sensing pathways that mediate the effects of nutrition on health and ageing. |
| doi_str_mv | 10.1530/JOE-15-0173 |
| format | Article |
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| ispartof | Journal of endocrinology, 2015-07, Vol.226 (1), p.R17-R28 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Aging - physiology AMP-Activated Protein Kinases - metabolism Animals Caloric Restriction Diet, Protein-Restricted Energy Intake - physiology Fibroblast Growth Factors - metabolism Food Humans Insulin - metabolism Insulin-Like Growth Factor I - metabolism Longevity - physiology Nutritional Physiological Phenomena Review Sirtuin 1 - metabolism TOR Serine-Threonine Kinases - metabolism |
| title | Macronutrients and caloric intake in health and longevity |
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