Blood flow/pump rotation ratio as an artificial lung performance monitoring tool during extracorporeal respiratory support using centrifugal pumps
To analyze the correlations of the blood flow/pump rotation ratio and the transmembrane pressure, CO2 and O2 transfer during the extracorporeal respiratory support. Five animals were instrumented and submitted to extracorporeal membrane oxygenation in a five-step protocol, including abdominal sepsis...
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| Veröffentlicht in: | Revista Brasileira de terapia intensiva 2015-04, Vol.27 (2), p.178-184 |
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| container_title | Revista Brasileira de terapia intensiva |
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| creator | Park, Marcelo Mendes, Pedro Vitale Hirota, Adriana Sayuri dos Santos, Edzangela Vasconcelos Costa, Eduardo Leite Vieira Azevedo, Luciano Cesar Pontes |
| description | To analyze the correlations of the blood flow/pump rotation ratio and the transmembrane pressure, CO2 and O2 transfer during the extracorporeal respiratory support.
Five animals were instrumented and submitted to extracorporeal membrane oxygenation in a five-step protocol, including abdominal sepsis and lung injury.
This study showed that blood flow/pump rotations ratio variations are dependent on extracorporeal membrane oxygenation blood flow in a positive logarithmic fashion. Blood flow/pump rotation ratio variations are negatively associated with transmembrane pressure (R2 = 0.5 for blood flow = 1500mL/minute and R2 = 0.4 for blood flow = 3500mL/minute, both with p < 0.001) and positively associated with CO2 transfer variations (R2 = 0.2 for sweep gas flow ≤ 6L/minute, p < 0.001, and R2 = 0.1 for sweep gas flow > 6L/minute, p = 0.006), and the blood flow/pump rotation ratio is not associated with O2 transfer variations (R2 = 0.01 for blood flow = 1500mL/minute, p = 0.19, and R2 = - 0.01 for blood flow = 3500 mL/minute, p = 0.46).
Blood flow/pump rotation ratio variation is negatively associated with transmembrane pressure and positively associated with CO2 transfer in this animal model. According to the clinical situation, a decrease in the blood flow/pump rotation ratio can indicate artificial lung dysfunction without the occurrence of hypoxemia. |
| doi_str_mv | 10.5935/0103-507X.20150030 |
| format | Article |
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Five animals were instrumented and submitted to extracorporeal membrane oxygenation in a five-step protocol, including abdominal sepsis and lung injury.
This study showed that blood flow/pump rotations ratio variations are dependent on extracorporeal membrane oxygenation blood flow in a positive logarithmic fashion. Blood flow/pump rotation ratio variations are negatively associated with transmembrane pressure (R2 = 0.5 for blood flow = 1500mL/minute and R2 = 0.4 for blood flow = 3500mL/minute, both with p < 0.001) and positively associated with CO2 transfer variations (R2 = 0.2 for sweep gas flow ≤ 6L/minute, p < 0.001, and R2 = 0.1 for sweep gas flow > 6L/minute, p = 0.006), and the blood flow/pump rotation ratio is not associated with O2 transfer variations (R2 = 0.01 for blood flow = 1500mL/minute, p = 0.19, and R2 = - 0.01 for blood flow = 3500 mL/minute, p = 0.46).
Blood flow/pump rotation ratio variation is negatively associated with transmembrane pressure and positively associated with CO2 transfer in this animal model. According to the clinical situation, a decrease in the blood flow/pump rotation ratio can indicate artificial lung dysfunction without the occurrence of hypoxemia.</description><identifier>ISSN: 0103-507X</identifier><identifier>EISSN: 1982-4335</identifier><identifier>DOI: 10.5935/0103-507X.20150030</identifier><identifier>PMID: 26340159</identifier><language>eng</language><publisher>Brazil: Associação Brasileira de Medicina intensiva</publisher><subject>Animals ; Blood Flow Velocity - physiology ; Carbon Dioxide - metabolism ; Disease Models, Animal ; Extracorporeal Membrane Oxygenation - methods ; Female ; Lung Injury - physiopathology ; Lung Injury - therapy ; Original ; Oxygen - metabolism ; Respiratory Function Tests ; Sepsis - therapy ; Swine</subject><ispartof>Revista Brasileira de terapia intensiva, 2015-04, Vol.27 (2), p.178-184</ispartof><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3170-13a49e2b32dae6db6ce1f5e62bc2d00433e4c07b6bcbbee834bfb6d0ba582b303</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489787/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489787/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26340159$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Park, Marcelo</creatorcontrib><creatorcontrib>Mendes, Pedro Vitale</creatorcontrib><creatorcontrib>Hirota, Adriana Sayuri</creatorcontrib><creatorcontrib>dos Santos, Edzangela Vasconcelos</creatorcontrib><creatorcontrib>Costa, Eduardo Leite Vieira</creatorcontrib><creatorcontrib>Azevedo, Luciano Cesar Pontes</creatorcontrib><title>Blood flow/pump rotation ratio as an artificial lung performance monitoring tool during extracorporeal respiratory support using centrifugal pumps</title><title>Revista Brasileira de terapia intensiva</title><addtitle>Rev Bras Ter Intensiva</addtitle><description>To analyze the correlations of the blood flow/pump rotation ratio and the transmembrane pressure, CO2 and O2 transfer during the extracorporeal respiratory support.
Five animals were instrumented and submitted to extracorporeal membrane oxygenation in a five-step protocol, including abdominal sepsis and lung injury.
This study showed that blood flow/pump rotations ratio variations are dependent on extracorporeal membrane oxygenation blood flow in a positive logarithmic fashion. Blood flow/pump rotation ratio variations are negatively associated with transmembrane pressure (R2 = 0.5 for blood flow = 1500mL/minute and R2 = 0.4 for blood flow = 3500mL/minute, both with p < 0.001) and positively associated with CO2 transfer variations (R2 = 0.2 for sweep gas flow ≤ 6L/minute, p < 0.001, and R2 = 0.1 for sweep gas flow > 6L/minute, p = 0.006), and the blood flow/pump rotation ratio is not associated with O2 transfer variations (R2 = 0.01 for blood flow = 1500mL/minute, p = 0.19, and R2 = - 0.01 for blood flow = 3500 mL/minute, p = 0.46).
Blood flow/pump rotation ratio variation is negatively associated with transmembrane pressure and positively associated with CO2 transfer in this animal model. According to the clinical situation, a decrease in the blood flow/pump rotation ratio can indicate artificial lung dysfunction without the occurrence of hypoxemia.</description><subject>Animals</subject><subject>Blood Flow Velocity - physiology</subject><subject>Carbon Dioxide - metabolism</subject><subject>Disease Models, Animal</subject><subject>Extracorporeal Membrane Oxygenation - methods</subject><subject>Female</subject><subject>Lung Injury - physiopathology</subject><subject>Lung Injury - therapy</subject><subject>Original</subject><subject>Oxygen - metabolism</subject><subject>Respiratory Function Tests</subject><subject>Sepsis - therapy</subject><subject>Swine</subject><issn>0103-507X</issn><issn>1982-4335</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkU1OwzAQhS0EouXnAiyQL5B2HCdOskGCij-pEhuQ2Fm24xSjJI7sBOg1ODFOSytYzWj8vufRPIQuCMzSgqZzIECjFLLXWQwkBaBwgKakyOMooTQ9RNO9YIJOvH8HYEAYO0aTmNEkIMUUfd_U1pa4qu3nvBuaDjvbi97YFruxYOGxaLFwvamMMqLG9dCucKddZV0jWqVxY1vTW2fCuLe2xuWw6fVX74SyrrNOB8xp35lgad0a-6EL0x4PfhQq3fbOVMMqqMYN_Bk6qkTt9flvPUUvd7fPi4do-XT_uLheRoqSDCJCRVLoWNK4FJqVkilNqlSzWKq4BAgn0ImCTDKppNQ6p4msJCtBijQPFNBTdLX17QbZ6HKzh6h550wj3JpbYfj_l9a88ZX94EmSF1meBYN4a6Cc9d7pas8S4GNCfAyAjwHwXUIBuvz76x7ZRUJ_AFw4k6A</recordid><startdate>20150401</startdate><enddate>20150401</enddate><creator>Park, Marcelo</creator><creator>Mendes, Pedro Vitale</creator><creator>Hirota, Adriana Sayuri</creator><creator>dos Santos, Edzangela Vasconcelos</creator><creator>Costa, Eduardo Leite Vieira</creator><creator>Azevedo, Luciano Cesar Pontes</creator><general>Associação Brasileira de Medicina intensiva</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20150401</creationdate><title>Blood flow/pump rotation ratio as an artificial lung performance monitoring tool during extracorporeal respiratory support using centrifugal pumps</title><author>Park, Marcelo ; Mendes, Pedro Vitale ; Hirota, Adriana Sayuri ; dos Santos, Edzangela Vasconcelos ; Costa, Eduardo Leite Vieira ; Azevedo, Luciano Cesar Pontes</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3170-13a49e2b32dae6db6ce1f5e62bc2d00433e4c07b6bcbbee834bfb6d0ba582b303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Blood Flow Velocity - physiology</topic><topic>Carbon Dioxide - metabolism</topic><topic>Disease Models, Animal</topic><topic>Extracorporeal Membrane Oxygenation - methods</topic><topic>Female</topic><topic>Lung Injury - physiopathology</topic><topic>Lung Injury - therapy</topic><topic>Original</topic><topic>Oxygen - metabolism</topic><topic>Respiratory Function Tests</topic><topic>Sepsis - therapy</topic><topic>Swine</topic><toplevel>online_resources</toplevel><creatorcontrib>Park, Marcelo</creatorcontrib><creatorcontrib>Mendes, Pedro Vitale</creatorcontrib><creatorcontrib>Hirota, Adriana Sayuri</creatorcontrib><creatorcontrib>dos Santos, Edzangela Vasconcelos</creatorcontrib><creatorcontrib>Costa, Eduardo Leite Vieira</creatorcontrib><creatorcontrib>Azevedo, Luciano Cesar Pontes</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Revista Brasileira de terapia intensiva</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Park, Marcelo</au><au>Mendes, Pedro Vitale</au><au>Hirota, Adriana Sayuri</au><au>dos Santos, Edzangela Vasconcelos</au><au>Costa, Eduardo Leite Vieira</au><au>Azevedo, Luciano Cesar Pontes</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Blood flow/pump rotation ratio as an artificial lung performance monitoring tool during extracorporeal respiratory support using centrifugal pumps</atitle><jtitle>Revista Brasileira de terapia intensiva</jtitle><addtitle>Rev Bras Ter Intensiva</addtitle><date>2015-04-01</date><risdate>2015</risdate><volume>27</volume><issue>2</issue><spage>178</spage><epage>184</epage><pages>178-184</pages><issn>0103-507X</issn><eissn>1982-4335</eissn><abstract>To analyze the correlations of the blood flow/pump rotation ratio and the transmembrane pressure, CO2 and O2 transfer during the extracorporeal respiratory support.
Five animals were instrumented and submitted to extracorporeal membrane oxygenation in a five-step protocol, including abdominal sepsis and lung injury.
This study showed that blood flow/pump rotations ratio variations are dependent on extracorporeal membrane oxygenation blood flow in a positive logarithmic fashion. Blood flow/pump rotation ratio variations are negatively associated with transmembrane pressure (R2 = 0.5 for blood flow = 1500mL/minute and R2 = 0.4 for blood flow = 3500mL/minute, both with p < 0.001) and positively associated with CO2 transfer variations (R2 = 0.2 for sweep gas flow ≤ 6L/minute, p < 0.001, and R2 = 0.1 for sweep gas flow > 6L/minute, p = 0.006), and the blood flow/pump rotation ratio is not associated with O2 transfer variations (R2 = 0.01 for blood flow = 1500mL/minute, p = 0.19, and R2 = - 0.01 for blood flow = 3500 mL/minute, p = 0.46).
Blood flow/pump rotation ratio variation is negatively associated with transmembrane pressure and positively associated with CO2 transfer in this animal model. According to the clinical situation, a decrease in the blood flow/pump rotation ratio can indicate artificial lung dysfunction without the occurrence of hypoxemia.</abstract><cop>Brazil</cop><pub>Associação Brasileira de Medicina intensiva</pub><pmid>26340159</pmid><doi>10.5935/0103-507X.20150030</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Blood Flow Velocity - physiology Carbon Dioxide - metabolism Disease Models, Animal Extracorporeal Membrane Oxygenation - methods Female Lung Injury - physiopathology Lung Injury - therapy Original Oxygen - metabolism Respiratory Function Tests Sepsis - therapy Swine |
| title | Blood flow/pump rotation ratio as an artificial lung performance monitoring tool during extracorporeal respiratory support using centrifugal pumps |
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