Investigating neural mechanisms of change of cognitive behavioural therapy for chronic fatigue syndrome: a randomized controlled trial
Chronic fatigue syndrome (CFS) is characterized by profound and disabling fatigue with no known somatic explanation. Cognitive behavioral therapy (CBT) has proven to be a successful intervention leading to a reduction in fatigue and disability. Based on previous neuroimaging findings, it has been su...
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| Veröffentlicht in: | BMC psychiatry 2015-07, Vol.15 (1), p.144-144, Article 144 |
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| creator | van Der Schaaf, Marieke E Schmits, Iris C Roerink, Megan Geurts, Dirk E M Toni, Ivan Roelofs, Karin De Lange, Floris P Nater, Urs M van der Meer, Jos W M Knoop, Hans |
| description | Chronic fatigue syndrome (CFS) is characterized by profound and disabling fatigue with no known somatic explanation. Cognitive behavioral therapy (CBT) has proven to be a successful intervention leading to a reduction in fatigue and disability. Based on previous neuroimaging findings, it has been suggested that central neural mechanisms may underlie CFS symptoms and play a role in the change brought on by CBT. In this randomized controlled trial we aim to further investigate the neural mechanisms that underlie fatigue in CFS and their change by CBT.
We will conduct a randomized controlled trial in which we collect anatomical and functional magnetic resonance imaging (MRI) measures from female CFS patients before and after CBT (N = 60) or waiting list (N = 30) and compare these with measures from age and education matched healthy controls (N = 30). By including a large treatment group we will also be able to compare patients that benefit from CBT with those that do not. In addition, to further investigate the role of endocrine and immune biomarkers in CFS, we will determine cortisol and cytokine concentrations in blood, hair and/or saliva.
This project creates an unique opportunity to enhance our understanding of CFS symptoms and its change by CBT in terms of neuroanatomical, neurofunctional, endocrinological and immunological mechanisms and can help to further improve future treatments strategies.
Dutch Trial Register #15852. Registered 9 December 2013 ( http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=4311 ). |
| doi_str_mv | 10.1186/s12888-015-0515-9 |
| format | Article |
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We will conduct a randomized controlled trial in which we collect anatomical and functional magnetic resonance imaging (MRI) measures from female CFS patients before and after CBT (N = 60) or waiting list (N = 30) and compare these with measures from age and education matched healthy controls (N = 30). By including a large treatment group we will also be able to compare patients that benefit from CBT with those that do not. In addition, to further investigate the role of endocrine and immune biomarkers in CFS, we will determine cortisol and cytokine concentrations in blood, hair and/or saliva.
This project creates an unique opportunity to enhance our understanding of CFS symptoms and its change by CBT in terms of neuroanatomical, neurofunctional, endocrinological and immunological mechanisms and can help to further improve future treatments strategies.
Dutch Trial Register #15852. Registered 9 December 2013 ( http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=4311 ).</description><identifier>ISSN: 1471-244X</identifier><identifier>EISSN: 1471-244X</identifier><identifier>DOI: 10.1186/s12888-015-0515-9</identifier><identifier>PMID: 26138726</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Adult ; Anniversaries ; Behavior ; Biomarkers - analysis ; Care and treatment ; Chronic fatigue syndrome ; Chronic pain ; Clinical Protocols ; Clinical trials ; Cognitive Behavioral Therapy - methods ; Cognitive therapy ; Fatigue Syndrome, Chronic - diagnosis ; Fatigue Syndrome, Chronic - metabolism ; Fatigue Syndrome, Chronic - psychology ; Fatigue Syndrome, Chronic - therapy ; Female ; Humans ; Investigations ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Mediation ; Medical imaging ; Middle Aged ; Monitoring, Physiologic - methods ; Neuroimaging ; Outcome Assessment (Health Care) ; Patients ; Physiological aspects ; Psychiatry ; Research Design ; Spectrum analysis ; Study Protocol</subject><ispartof>BMC psychiatry, 2015-07, Vol.15 (1), p.144-144, Article 144</ispartof><rights>COPYRIGHT 2015 BioMed Central Ltd.</rights><rights>Copyright BioMed Central 2015</rights><rights>van der Schaaf et al. 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c564t-49fe0373392fb0e8398b1f97e279dfff4ef4d91f42f6d2670d0ada4454928433</citedby><cites>FETCH-LOGICAL-c564t-49fe0373392fb0e8398b1f97e279dfff4ef4d91f42f6d2670d0ada4454928433</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489043/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489043/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27922,27923,53789,53791</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26138726$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>van Der Schaaf, Marieke E</creatorcontrib><creatorcontrib>Schmits, Iris C</creatorcontrib><creatorcontrib>Roerink, Megan</creatorcontrib><creatorcontrib>Geurts, Dirk E M</creatorcontrib><creatorcontrib>Toni, Ivan</creatorcontrib><creatorcontrib>Roelofs, Karin</creatorcontrib><creatorcontrib>De Lange, Floris P</creatorcontrib><creatorcontrib>Nater, Urs M</creatorcontrib><creatorcontrib>van der Meer, Jos W M</creatorcontrib><creatorcontrib>Knoop, Hans</creatorcontrib><title>Investigating neural mechanisms of change of cognitive behavioural therapy for chronic fatigue syndrome: a randomized controlled trial</title><title>BMC psychiatry</title><addtitle>BMC Psychiatry</addtitle><description>Chronic fatigue syndrome (CFS) is characterized by profound and disabling fatigue with no known somatic explanation. Cognitive behavioral therapy (CBT) has proven to be a successful intervention leading to a reduction in fatigue and disability. Based on previous neuroimaging findings, it has been suggested that central neural mechanisms may underlie CFS symptoms and play a role in the change brought on by CBT. In this randomized controlled trial we aim to further investigate the neural mechanisms that underlie fatigue in CFS and their change by CBT.
We will conduct a randomized controlled trial in which we collect anatomical and functional magnetic resonance imaging (MRI) measures from female CFS patients before and after CBT (N = 60) or waiting list (N = 30) and compare these with measures from age and education matched healthy controls (N = 30). By including a large treatment group we will also be able to compare patients that benefit from CBT with those that do not. In addition, to further investigate the role of endocrine and immune biomarkers in CFS, we will determine cortisol and cytokine concentrations in blood, hair and/or saliva.
This project creates an unique opportunity to enhance our understanding of CFS symptoms and its change by CBT in terms of neuroanatomical, neurofunctional, endocrinological and immunological mechanisms and can help to further improve future treatments strategies.
Dutch Trial Register #15852. Registered 9 December 2013 ( http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=4311 ).</description><subject>Adult</subject><subject>Anniversaries</subject><subject>Behavior</subject><subject>Biomarkers - analysis</subject><subject>Care and treatment</subject><subject>Chronic fatigue syndrome</subject><subject>Chronic pain</subject><subject>Clinical Protocols</subject><subject>Clinical trials</subject><subject>Cognitive Behavioral Therapy - methods</subject><subject>Cognitive therapy</subject><subject>Fatigue Syndrome, Chronic - diagnosis</subject><subject>Fatigue Syndrome, Chronic - metabolism</subject><subject>Fatigue Syndrome, Chronic - psychology</subject><subject>Fatigue Syndrome, Chronic - therapy</subject><subject>Female</subject><subject>Humans</subject><subject>Investigations</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Mediation</subject><subject>Medical imaging</subject><subject>Middle Aged</subject><subject>Monitoring, Physiologic - methods</subject><subject>Neuroimaging</subject><subject>Outcome Assessment (Health Care)</subject><subject>Patients</subject><subject>Physiological aspects</subject><subject>Psychiatry</subject><subject>Research Design</subject><subject>Spectrum analysis</subject><subject>Study Protocol</subject><issn>1471-244X</issn><issn>1471-244X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNptUt1uFCEYnRiNrdUH8MaQeOPNVP6GAS9MmsafJk286YV3hB0-ZmkYWGFmk_UBfG7Z3VpbY0jgBM458H2cpnlN8DkhUrwvhEopW0y6Fnd1Uk-aU8J70lLOvz99gE-aF6XcYkx62ZHnzQkVhMmeitPm11XcQpn9aGYfRxRhySagCYa1ib5MBSWH9niEA0pj9LPfAlrB2mx9OrDnNWSz2SGXcuXmFP2AXPUbF0BlF21OE3xABmUTbZr8T7DVKM45hVDhnL0JL5tnzoQCr-7Ws-bm86eby6_t9bcvV5cX1-3QCT63XDnArGdMUbfCIJmSK-JUD7RX1jnHwXGriOPUCUtFjy021nDecUUlZ-ys-Xi03SyrCewA9RUm6E32k8k7nYzXj0-iX-sxbTXnUuGDwbs7g5x-LLVxevJlgBBMhLQUTYTiSjDBcaW-_Yd6W9sVa3W6fgOWpA7xlzWaANpHl-q9w95UX3SccNyrg9f5f1h1WJh87SU4X_cfCchRMORUSgZ3XyPBep8dfcyOrtnR--xoVTVvHjbnXvEnLOw3FUXBsQ</recordid><startdate>20150703</startdate><enddate>20150703</enddate><creator>van Der Schaaf, Marieke E</creator><creator>Schmits, Iris C</creator><creator>Roerink, Megan</creator><creator>Geurts, Dirk E M</creator><creator>Toni, Ivan</creator><creator>Roelofs, Karin</creator><creator>De Lange, Floris P</creator><creator>Nater, Urs M</creator><creator>van der Meer, Jos W M</creator><creator>Knoop, Hans</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150703</creationdate><title>Investigating neural mechanisms of change of cognitive behavioural therapy for chronic fatigue syndrome: a randomized controlled trial</title><author>van Der Schaaf, Marieke E ; Schmits, Iris C ; Roerink, Megan ; Geurts, Dirk E M ; Toni, Ivan ; Roelofs, Karin ; De Lange, Floris P ; Nater, Urs M ; van der Meer, Jos W M ; Knoop, Hans</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c564t-49fe0373392fb0e8398b1f97e279dfff4ef4d91f42f6d2670d0ada4454928433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Anniversaries</topic><topic>Behavior</topic><topic>Biomarkers - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMC psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van Der Schaaf, Marieke E</au><au>Schmits, Iris C</au><au>Roerink, Megan</au><au>Geurts, Dirk E M</au><au>Toni, Ivan</au><au>Roelofs, Karin</au><au>De Lange, Floris P</au><au>Nater, Urs M</au><au>van der Meer, Jos W M</au><au>Knoop, Hans</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Investigating neural mechanisms of change of cognitive behavioural therapy for chronic fatigue syndrome: a randomized controlled trial</atitle><jtitle>BMC psychiatry</jtitle><addtitle>BMC Psychiatry</addtitle><date>2015-07-03</date><risdate>2015</risdate><volume>15</volume><issue>1</issue><spage>144</spage><epage>144</epage><pages>144-144</pages><artnum>144</artnum><issn>1471-244X</issn><eissn>1471-244X</eissn><abstract>Chronic fatigue syndrome (CFS) is characterized by profound and disabling fatigue with no known somatic explanation. Cognitive behavioral therapy (CBT) has proven to be a successful intervention leading to a reduction in fatigue and disability. Based on previous neuroimaging findings, it has been suggested that central neural mechanisms may underlie CFS symptoms and play a role in the change brought on by CBT. In this randomized controlled trial we aim to further investigate the neural mechanisms that underlie fatigue in CFS and their change by CBT.
We will conduct a randomized controlled trial in which we collect anatomical and functional magnetic resonance imaging (MRI) measures from female CFS patients before and after CBT (N = 60) or waiting list (N = 30) and compare these with measures from age and education matched healthy controls (N = 30). By including a large treatment group we will also be able to compare patients that benefit from CBT with those that do not. In addition, to further investigate the role of endocrine and immune biomarkers in CFS, we will determine cortisol and cytokine concentrations in blood, hair and/or saliva.
This project creates an unique opportunity to enhance our understanding of CFS symptoms and its change by CBT in terms of neuroanatomical, neurofunctional, endocrinological and immunological mechanisms and can help to further improve future treatments strategies.
Dutch Trial Register #15852. Registered 9 December 2013 ( http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=4311 ).</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>26138726</pmid><doi>10.1186/s12888-015-0515-9</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Anniversaries Behavior Biomarkers - analysis Care and treatment Chronic fatigue syndrome Chronic pain Clinical Protocols Clinical trials Cognitive Behavioral Therapy - methods Cognitive therapy Fatigue Syndrome, Chronic - diagnosis Fatigue Syndrome, Chronic - metabolism Fatigue Syndrome, Chronic - psychology Fatigue Syndrome, Chronic - therapy Female Humans Investigations Magnetic resonance imaging Magnetic Resonance Imaging - methods Mediation Medical imaging Middle Aged Monitoring, Physiologic - methods Neuroimaging Outcome Assessment (Health Care) Patients Physiological aspects Psychiatry Research Design Spectrum analysis Study Protocol |
| title | Investigating neural mechanisms of change of cognitive behavioural therapy for chronic fatigue syndrome: a randomized controlled trial |
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