A Novel Once-Daily Fixed-Dose Combination of Memantine Extended Release and Donepezil for the Treatment of Moderate to Severe Alzheimer’s Disease: Two Phase I Studies in Healthy Volunteers

Background Combining two standard-of-care medications for Alzheimer’s disease (AD) into a single once-daily dosage unit may improve treatment adherence, facilitate drug administration, and reduce caregiver burden. A new fixed-dose combination (FDC) capsule containing 28 mg memantine extended release...

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Veröffentlicht in:	Clinical drug investigation 2015-07, Vol.35 (7), p.427-435
Hauptverfasser:	Boinpally, Ramesh, Chen, Laishun, Zukin, Stephen R., McClure, Natalie, Hofbauer, Robert K., Periclou, Antonia
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Alzheimer Disease - drug therapy Biological Availability Cross-Over Studies Donepezil Drug Therapy, Combination Female Healthy Volunteers Humans Indans - administration & dosage Indans - adverse effects Indans - pharmacokinetics Internal Medicine Male Medicine Medicine & Public Health Memantine - administration & dosage Memantine - adverse effects Memantine - pharmacokinetics Original Original Research Article Pharmacology/Toxicology Pharmacotherapy Piperidines - administration & dosage Piperidines - adverse effects Piperidines - pharmacokinetics
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