Epigenetic Genome Mining of an Endophytic Fungus Leads to the Pleiotropic Biosynthesis of Natural Products

The small‐molecule biosynthetic potential of most filamentous fungi has remained largely unexplored and represents an attractive source for the discovery of new compounds. Genome sequencing of Calcarisporium arbuscula, a mushroom‐endophytic fungus, revealed 68 core genes that are involved in natural...

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Veröffentlicht in:	Angewandte Chemie International Edition 2015-06, Vol.54 (26), p.7592-7596
Hauptverfasser:	Mao, Xu-Ming, Xu, Wei, Li, Dehai, Yin, Wen-Bing, Chooi, Yit-Heng, Li, Yong-Quan, Tang, Yi, Hu, Youcai
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Products - chemical synthesis Biological Products - chemistry Biosynthesis Clusters endophytic fungi Epigenetics Epigenomics Fungi Fungi - metabolism Gene Expression Genes Genomes Genomics Histones Inhibitors Molecular Structure Natural products
Online-Zugang:	Volltext
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