MiRNA inhibition in tissue engineering and regenerative medicine
MicroRNAs (miRNAs) are noncoding RNAs that provide an endogenous negative feedback mechanism for translation of messenger RNA (mRNA) into protein. Single miRNAs can regulate hundreds of mRNAs, enabling miRNAs to orchestrate robust biological responses by simultaneously impacting multiple gene networ...
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| Veröffentlicht in: | Advanced drug delivery reviews 2015-07, Vol.88, p.123-137 |
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| container_title | Advanced drug delivery reviews |
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| creator | Beavers, Kelsey R. Nelson, Christopher E. Duvall, Craig L. |
| description | MicroRNAs (miRNAs) are noncoding RNAs that provide an endogenous negative feedback mechanism for translation of messenger RNA (mRNA) into protein. Single miRNAs can regulate hundreds of mRNAs, enabling miRNAs to orchestrate robust biological responses by simultaneously impacting multiple gene networks. MiRNAs can act as master regulators of normal and pathological tissue development, homeostasis, and repair, which has motivated expanding efforts toward the development of technologies for therapeutically modulating miRNA activity for regenerative medicine and tissue engineering applications. This review highlights the tools currently available for miRNA inhibition and their recent therapeutic applications for improving tissue repair.
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| doi_str_mv | 10.1016/j.addr.2014.12.006 |
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[Display omitted]</description><subject>Anti-miR</subject><subject>Bone and Bones - physiology</subject><subject>Cicatrix - metabolism</subject><subject>Genetic Vectors</subject><subject>Humans</subject><subject>Inflammation - metabolism</subject><subject>Kidney - physiology</subject><subject>Liver - physiology</subject><subject>MicroRNAs - antagonists & inhibitors</subject><subject>MiRNA</subject><subject>MiRNA inhibition</subject><subject>Muscle, Skeletal - physiology</subject><subject>Myocardium - metabolism</subject><subject>Neovascularization, Pathologic - metabolism</subject><subject>Regeneration - physiology</subject><subject>Regenerative medicine</subject><subject>Regenerative Medicine - methods</subject><subject>RNA, Messenger - metabolism</subject><subject>Tissue engineering</subject><subject>Tissue Engineering - methods</subject><subject>Tissue Scaffolds</subject><subject>Wound Healing - physiology</subject><issn>0169-409X</issn><issn>1872-8294</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFqGzEQhkVJqZ00L9BD2GMuu5FkzVqCUBpCmgSSFkoCuQmtNLbH2NpUWhvy9pVxGppLT6NhvvlHfIx9EbwRXLRny8aFkBrJhWqEbDhvP7Cx0FNZa2nUARsXyNSKm6cRO8x5ybmQ05Z_YiMJABMD0zH7dk-_flxUFBfU0UB9LM9qoJw3WGGcU0RMFOeVi6FKOMeIyQ20xWqNgXwZf2YfZ26V8fi1HrHH71cPlzf13c_r28uLu9qDhKEGpTotBaLhLSjQhnedcyBQQauULj0IrVuYBAjeeWOcAQ7ao_YhtDOcHLGv-9znTVdue4xDciv7nGjt0ovtHdn3k0gLO--3tqSD0bwEnL4GpP73BvNg15Q9rlYuYr_JtriaSiGlgYLKPepTn3PC2dsZwe1OvV3anXq7U2-FtEV9WTr594NvK39dF-B8D2DRtCVMNnvC6IvIhH6woaf_5f8B6OuVpA</recordid><startdate>20150701</startdate><enddate>20150701</enddate><creator>Beavers, Kelsey R.</creator><creator>Nelson, Christopher E.</creator><creator>Duvall, Craig L.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150701</creationdate><title>MiRNA inhibition in tissue engineering and regenerative medicine</title><author>Beavers, Kelsey R. ; Nelson, Christopher E. ; Duvall, Craig L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c525t-544b821ee906545890bbaa51e4564488905188653d5dcac99a95058ce8cdd6fe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Anti-miR</topic><topic>Bone and Bones - physiology</topic><topic>Cicatrix - metabolism</topic><topic>Genetic Vectors</topic><topic>Humans</topic><topic>Inflammation - metabolism</topic><topic>Kidney - physiology</topic><topic>Liver - physiology</topic><topic>MicroRNAs - antagonists & inhibitors</topic><topic>MiRNA</topic><topic>MiRNA inhibition</topic><topic>Muscle, Skeletal - physiology</topic><topic>Myocardium - metabolism</topic><topic>Neovascularization, Pathologic - metabolism</topic><topic>Regeneration - physiology</topic><topic>Regenerative medicine</topic><topic>Regenerative Medicine - methods</topic><topic>RNA, Messenger - metabolism</topic><topic>Tissue engineering</topic><topic>Tissue Engineering - methods</topic><topic>Tissue Scaffolds</topic><topic>Wound Healing - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Beavers, Kelsey R.</creatorcontrib><creatorcontrib>Nelson, Christopher E.</creatorcontrib><creatorcontrib>Duvall, Craig L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Advanced drug delivery reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Beavers, Kelsey R.</au><au>Nelson, Christopher E.</au><au>Duvall, Craig L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MiRNA inhibition in tissue engineering and regenerative medicine</atitle><jtitle>Advanced drug delivery reviews</jtitle><addtitle>Adv Drug Deliv Rev</addtitle><date>2015-07-01</date><risdate>2015</risdate><volume>88</volume><spage>123</spage><epage>137</epage><pages>123-137</pages><issn>0169-409X</issn><eissn>1872-8294</eissn><abstract>MicroRNAs (miRNAs) are noncoding RNAs that provide an endogenous negative feedback mechanism for translation of messenger RNA (mRNA) into protein. Single miRNAs can regulate hundreds of mRNAs, enabling miRNAs to orchestrate robust biological responses by simultaneously impacting multiple gene networks. MiRNAs can act as master regulators of normal and pathological tissue development, homeostasis, and repair, which has motivated expanding efforts toward the development of technologies for therapeutically modulating miRNA activity for regenerative medicine and tissue engineering applications. This review highlights the tools currently available for miRNA inhibition and their recent therapeutic applications for improving tissue repair.
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| fulltext | fulltext |
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| ispartof | Advanced drug delivery reviews, 2015-07, Vol.88, p.123-137 |
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| language | eng |
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| source | MEDLINE; ScienceDirect Freedom Collection (Elsevier) |
| subjects | Anti-miR Bone and Bones - physiology Cicatrix - metabolism Genetic Vectors Humans Inflammation - metabolism Kidney - physiology Liver - physiology MicroRNAs - antagonists & inhibitors MiRNA MiRNA inhibition Muscle, Skeletal - physiology Myocardium - metabolism Neovascularization, Pathologic - metabolism Regeneration - physiology Regenerative medicine Regenerative Medicine - methods RNA, Messenger - metabolism Tissue engineering Tissue Engineering - methods Tissue Scaffolds Wound Healing - physiology |
| title | MiRNA inhibition in tissue engineering and regenerative medicine |
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