Cancer-targeted IL-12 controls human rhabdomyosarcoma by senescence induction and myogenic differentiation

Stimulating the immune system to attack cancer is a promising approach, even for the control of advanced cancers. Several cytokines that promote interferon-γ-dominated immune responses show antitumor activity, with interleukin 12 (IL-12) being of major importance. Here, we used an antibody-IL-12 fus...

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Veröffentlicht in:	Oncoimmunology 2015-07, Vol.4 (7), p.e1014760-e1014760
Hauptverfasser:	Schilbach, Karin, Alkhaled, Mohammed, Welker, Christian, Eckert, Franziska, Blank, Gregor, Ziegler, Hendrik, Sterk, Marco, Müller, Friederike, Sonntag, Katja, Wieder, Thomas, Braumüller, Heidi, Schmitt, Julia, Eyrich, Matthias, Schleicher, Sabine, Seitz, Christian, Erbacher, Annika, Pichler, Bernd J, Müller, Hartmut, Tighe, Robert, Lim, Annick, Gillies, Stephen D, Strittmatter, Wolfgang, Röcken, Martin, Handgretinger, Rupert
Format:	Artikel
Sprache:	eng
Schlagworte:	1-induced senescence 17 cells cancer-targeted IL-12 CIP1, CDK-interacting protein 1 differentiation DNAM-1, DNAX accessory molecule-1 humanized mice immunocytokine immunotherapy KIR, killer-cell immunoglobulin-like receptor M1/M2 macrophages MICA/B, MHC class I polypeptide-related sequence A/B NKG, natural killer group NSG, NOD SCID gamma chain knock out mouse Original Research PCNA, proliferating cell nuclear antigen pHP1γ, phosphorylated heterochromatin protein 1 gamma PVR, poliovirus receptor rhabdomyosarcoma RMS, rhabdomyosarcoma, (eRMS: embryonal, aRMS: alveolar) ROI, region of interest RORC, RAR-related orphan receptor C SCT, stem cell transplantation SPECT/CT, single-photon emission computed tomography TRBV, T-cell receptor beta chain tumor-infiltrating lymphocytes ULBP, UL16 binding protein WAF, wild-type activating fragment
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