Genome-Wide Expression Profiling of Anoxia/Reoxygenation in Rat Cardiomyocytes Uncovers the Role of MitoKATP in Energy Homeostasis

Mitochondrial ATP-sensitive potassium channel (mitoKATP) is a common end effector of many protective stimuli in myocardial ischemia-reperfusion injury (MIRI). However, the specific molecular mechanism underlying its myocardial protective effect is not well elucidated. We characterized an anoxia/reox...

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Veröffentlicht in:	Oxidative medicine and cellular longevity 2015-01, Vol.2015 (2015), p.1-14
Hauptverfasser:	Yu, Tian, Zhang, Lin, Zhao, Li, Sun, Wenting, Liu, Yun, Cao, Song, Liu, Xinkui
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyl-CoA Dehydrogenase - genetics Acyl-CoA Dehydrogenase - metabolism Adenosine Triphosphate - metabolism Anesthesiology Animals Calcium - metabolism Cardiomyocytes Cell Survival - drug effects Decanoic Acids - pharmacology Diazoxide - pharmacology Energy Metabolism - genetics Gene expression Gene Expression Profiling Genome Heart attacks Homeostasis Hydroxy Acids - pharmacology Hypotheses Hypoxia Ischemia Isocitrate Dehydrogenase - genetics Isocitrate Dehydrogenase - metabolism Laboratory animals Male Metabolism Mitochondria - metabolism Myocytes, Cardiac - cytology Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism NADH Dehydrogenase - genetics NADH Dehydrogenase - metabolism Potassium Channels - chemistry Potassium Channels - metabolism Proteins Rats Rats, Sprague-Dawley Real-Time Polymerase Chain Reaction Rodents Studies
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