Adaptation of HepG2 cells to a steady-state reduction in the content of protein phosphatase 6 (PP6) catalytic subunit

Protein phosphatase 6 (PP6) is a ubiquitous Ser/Thr phosphatase involved in an array of cellular processes. To assess the potential of PP6 as a therapeutic target in liver disorders, we attenuated expression of the PP6 catalytic subunit in HepG2 cells using lentiviral-transduced shRNA. Two PP6 knock...

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Veröffentlicht in:	Experimental cell research 2015-07, Vol.335 (2), p.224-237
Hauptverfasser:	Boylan, Joan M., Salomon, Arthur R., Tantravahi, Umadevi, Gruppuso, Philip A.
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Adaptation, Physiological APOPTOSIS BIOLOGICAL PATHWAYS BLEOMYCIN Catalytic Domain CELL CYCLE CELL PROLIFERATION DNA DAMAGES DNA REPAIR DNA REPLICATION Gene expression Gene Knockdown Techniques GENES Hep G2 Cells Hepatic cells Humans INFLAMMATION LIVER MASS SPECTROSCOPY MESSENGER-RNA Peptides Phenotype Phosphoprotein Phosphatases - physiology Phosphoproteins - metabolism PHOSPHORYLATION POLYPLOIDY Protein expression Protein phosphatase 6 Protein phosphorylation Protein Processing, Post-Translational Protein Subunits - physiology PROTEINS Proteome - metabolism REDUCTION RNA, Small Interfering - genetics Signal transduction SIGNALS SPLICING Transcriptome
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