Rem uncouples excitation-contraction coupling in adult skeletal muscle fibers

In skeletal muscle, excitation-contraction (EC) coupling requires depolarization-induced conformational rearrangements in L-type Ca(2+) channel (Ca(V)1.1) to be communicated to the type 1 ryanodine-sensitive Ca(2+) release channel (RYR1) of the sarcoplasmic reticulum (SR) via transient protein-prote...

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Veröffentlicht in:	The Journal of general physiology 2015-07, Vol.146 (1), p.97-108
Hauptverfasser:	Beqollari, Donald, Romberg, Christin F, Filipova, Dilyana, Meza, Ulises, Papadopoulos, Symeon, Bannister, Roger A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry Calcium Calcium - metabolism Calcium Channels, L-Type - metabolism Calcium Signaling - physiology Cell Membrane - metabolism Cell Membrane - physiology Excitation Contraction Coupling - physiology Male Membranes Mice Mice, Inbred C57BL Molecular Sequence Data Monomeric GTP-Binding Proteins - metabolism Muscle Contraction - physiology Muscle Fibers, Skeletal - metabolism Muscle Fibers, Skeletal - physiology Musculoskeletal system Physiology Protein Binding - physiology Protein expression Ryanodine Receptor Calcium Release Channel - metabolism Sarcoplasmic Reticulum - metabolism Sarcoplasmic Reticulum - physiology Signal transduction
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