Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes

Brain glucose metabolism is impaired in Alzheimer's disease (AD), the most common form of dementia. Type 2 diabetes mellitus (T2DM) is reported to increase the risk for dementia, including AD, but the underlying mechanism is not understood. Here, we investigated the brain insulin–PI3K–AKT signa...

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Veröffentlicht in:	The Journal of pathology 2011-09, Vol.225 (1), p.54-62
Hauptverfasser:	Liu, Ying, Liu, Fei, Grundke-Iqbal, Inge, Iqbal, Khalid, Gong, Cheng-Xin
Format:	Artikel
Sprache:	eng
Schlagworte:	Acylation Adult and adolescent clinical studies Aged Aged, 80 and over AKT Alzheimer Disease - etiology Alzheimer Disease - metabolism Alzheimer's disease Arrestins - metabolism beta-Arrestins beta-N-Acetylhexosaminidases - metabolism Biological and medical sciences Brain Brain - metabolism Calpain Calpain - metabolism Cognitive ability Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dementia disorders diabetes Diabetes mellitus Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - metabolism Female Glucose metabolism Glycogen synthase kinase 3 GSK-3β Humans Insulin Insulin - metabolism Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Molecular modelling Neurodegenerative diseases Neurology Organic mental disorders. Neuropsychology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Phosphorylation Phosphorylation - physiology PI3K Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Signal transduction Signal Transduction - physiology Tau protein tau Proteins - metabolism β-arrestin-2
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