The oncogenic receptor ErbB2 modulates gemcitabine and irinotecan/SN-38 chemoresistance of human pancreatic cancer cells via hCNT1 transporter and multidrug-resistance associated protein MRP-2

Pancreatic adenocarcinoma (PDAC) is one of the most deadly cancers because of a lack of early diagnostic markers and efficient therapeutics. The fluorinated analog of deoxycytidine, gemcitabine and emerging FOLFIRINOX protocol (5-fluorouracil (5-FU), irinotecan/SN-38, oxaliplatin and leucovorin) are...

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Veröffentlicht in:	Oncotarget 2015-05, Vol.6 (13), p.10853-10867
Hauptverfasser:	Skrypek, Nicolas, Vasseur, Romain, Vincent, Audrey, Duchêne, Bélinda, Van Seuningen, Isabelle, Jonckheere, Nicolas
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antimetabolites, Antineoplastic - metabolism Antimetabolites, Antineoplastic - pharmacology Antineoplastic Combined Chemotherapy Protocols - pharmacology Camptothecin - analogs & derivatives Camptothecin - metabolism Camptothecin - pharmacology Cancer Cell Death - drug effects Cell Line, Tumor Databases, Genetic Deoxycytidine - analogs & derivatives Deoxycytidine - metabolism Deoxycytidine - pharmacology Drug Resistance, Neoplasm - genetics Gene Expression Regulation, Neoplastic Gene Knockdown Techniques Humans Life Sciences Male Membrane Transport Proteins - genetics Membrane Transport Proteins - metabolism Mice, SCID Multidrug Resistance-Associated Proteins - genetics Multidrug Resistance-Associated Proteins - metabolism Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - genetics Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Receptor, ErbB-2 - genetics Receptor, ErbB-2 - metabolism Research Paper RNA Interference RNA, Messenger - metabolism Signal Transduction - drug effects Transfection Xenograft Model Antitumor Assays
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