Multiple Mechanisms of Unfolded Protein Response–Induced Cell Death

Eukaryotic cells fold and assemble membrane and secreted proteins in the endoplasmic reticulum (ER), before delivery to other cellular compartments or the extracellular environment. Correctly folded proteins are released from the ER, and poorly folded proteins are retained until they achieve stable...

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Veröffentlicht in:	The American journal of pathology 2015-07, Vol.185 (7), p.1800-1808
Hauptverfasser:	Hiramatsu, Nobuhiko, Chiang, Wei-Chieh, Kurt, Timothy D, Sigurdson, Christina J, Lin, Jonathan H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis ASIP Cotran Early Career Investigator Award Lecture Awards and Prizes eIF-2 Kinase - metabolism Endoplasmic Reticulum - metabolism Endoplasmic Reticulum Stress Endoribonucleases - metabolism Eukaryotic Cells - physiology Humans Mammals Models, Biological Molecular Chaperones - metabolism Pathology Protein Biosynthesis Protein Serine-Threonine Kinases - metabolism Signal Transduction Societies, Medical Unfolded Protein Response United States
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