Improved insulin sensitivity after exercise training is linked to reduced plasma C14:0 ceramide in obesity and type 2 diabetes
Objective To assess the effect of exercise training on insulin sensitivity and plasma ceramides in obesity and type 2 diabetes (T2D). Methods Twenty‐four adults with obesity and normal glucose tolerance (NGT, n = 14) or diabetes (n = 10) were studied before and after a 12‐week supervised exercise‐tr...
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| Veröffentlicht in: | Obesity (Silver Spring, Md.) Md.), 2015-07, Vol.23 (7), p.1414-1421 |
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| container_title | Obesity (Silver Spring, Md.) |
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| creator | Kasumov, Takhar Solomon, Thomas P.J. Hwang, Calvin Huang, Hazel Haus, Jacob M. Zhang, Renliang Kirwan, John P. |
| description | Objective
To assess the effect of exercise training on insulin sensitivity and plasma ceramides in obesity and type 2 diabetes (T2D).
Methods
Twenty‐four adults with obesity and normal glucose tolerance (NGT, n = 14) or diabetes (n = 10) were studied before and after a 12‐week supervised exercise‐training program (5 days/week, 1 h/day, 80‐85% of maximum heart rate). Changes in body composition were assessed using hydrostatic weighing and computed tomography. Peripheral tissue insulin sensitivity was assessed by a 40 mU/m2/min hyperinsulinemic euglycemic clamp. Plasma ceramides (C14:0, C16:0, C18:0, C18:1, C20:0, C24:0, and C24:1) were quantified using electrospray ionization tandem mass spectrometry after separation with HPLC.
Results
Plasma ceramides were similar for the subjects with obesity and NGT and the subjects with diabetes, despite differences in glucose tolerance. Exercise significantly reduced body weight and adiposity and increased peripheral insulin sensitivity in both groups (P |
| doi_str_mv | 10.1002/oby.21117 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4482773</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3774065561</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4797-d51c9964d2012e9ec936ae28d297561b36e4c364b57e1ef2cb69f04324b14c4b3</originalsourceid><addsrcrecordid>eNpdkU1v1DAQhi0EoqVw4A8gS1y4bOuxHXvNAams-KhUqReQ4GQ5zmxxSexgJwu58Nsx27ICTn6lefxoRi8hT4GdAmP8LLXLKQcAfY8cgxFspYX5dP-Q13BEHpVyw5hUrIGH5Ig3RimhxDH5eTGMOe2woyGWuQ-RFowlTGEXpoW67YSZ4g_MPhSkU3YhhnhNQ6EV_Vp_TYlm7GZf49i7Mji6AfmSUY_ZDaHDqqWpxbK3xcovI1JOu-BanLA8Jg-2ri_45O49IR_fvvmweb-6vHp3sTm_XHmpjV51DXhjlOw4A44GvRHKIV933OhGQSsUSi-UbBuNgFvuW2W2TAouW5BetuKEvLr1jnM7YOcx1lt6O-YwuLzY5IL9dxLDF3uddlbKNddaVMGLO0FO32Yskx1C8dj3LmKaiwVloDFrqVlFn_-H3qQ5x3qeBc24YUZAU6lnf290WOVPNRU4uwW-hx6XwxyY_d25rZ3bfef26vXnfRC_AOYhn4w</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1702909315</pqid></control><display><type>article</type><title>Improved insulin sensitivity after exercise training is linked to reduced plasma C14:0 ceramide in obesity and type 2 diabetes</title><source>Wiley Free Content</source><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Kasumov, Takhar ; Solomon, Thomas P.J. ; Hwang, Calvin ; Huang, Hazel ; Haus, Jacob M. ; Zhang, Renliang ; Kirwan, John P.</creator><creatorcontrib>Kasumov, Takhar ; Solomon, Thomas P.J. ; Hwang, Calvin ; Huang, Hazel ; Haus, Jacob M. ; Zhang, Renliang ; Kirwan, John P.</creatorcontrib><description>Objective
To assess the effect of exercise training on insulin sensitivity and plasma ceramides in obesity and type 2 diabetes (T2D).
Methods
Twenty‐four adults with obesity and normal glucose tolerance (NGT, n = 14) or diabetes (n = 10) were studied before and after a 12‐week supervised exercise‐training program (5 days/week, 1 h/day, 80‐85% of maximum heart rate). Changes in body composition were assessed using hydrostatic weighing and computed tomography. Peripheral tissue insulin sensitivity was assessed by a 40 mU/m2/min hyperinsulinemic euglycemic clamp. Plasma ceramides (C14:0, C16:0, C18:0, C18:1, C20:0, C24:0, and C24:1) were quantified using electrospray ionization tandem mass spectrometry after separation with HPLC.
Results
Plasma ceramides were similar for the subjects with obesity and NGT and the subjects with diabetes, despite differences in glucose tolerance. Exercise significantly reduced body weight and adiposity and increased peripheral insulin sensitivity in both groups (P < 0.05). In addition, plasma C14:0, C16:0, C18:1, and C24:0 ceramide levels were reduced in all subjects following the intervention (P < 0.05). Decreases in total (r = −0.51, P = 0.02) and C14:0 (r = −0.56, P = 0.009) ceramide were negatively correlated with the increase in insulin sensitivity.
Conclusions
Ceramides are linked to exercise training‐induced improvements in insulin sensitivity, and plasma C14:0 ceramide may provide a specific target for investigating lipid‐related insulin resistance in obesity and T2D.</description><identifier>ISSN: 1930-7381</identifier><identifier>EISSN: 1930-739X</identifier><identifier>DOI: 10.1002/oby.21117</identifier><identifier>PMID: 25966363</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Adult ; Body Composition ; Body Weight ; Ceramides - blood ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - therapy ; Exercise ; Exercise - physiology ; Female ; Glucose ; Humans ; Hyperglycemia ; Insulin ; Insulin resistance ; Insulin Resistance - physiology ; Male ; Middle Aged ; Obesity ; Obesity - blood ; Obesity - therapy ; Physical Endurance - physiology ; Plasma ; Rodents ; Weight control</subject><ispartof>Obesity (Silver Spring, Md.), 2015-07, Vol.23 (7), p.1414-1421</ispartof><rights>2015 The Obesity Society</rights><rights>2015 The Obesity Society.</rights><rights>Copyright Blackwell Publishing Ltd. Jul 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4797-d51c9964d2012e9ec936ae28d297561b36e4c364b57e1ef2cb69f04324b14c4b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Foby.21117$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Foby.21117$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25966363$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kasumov, Takhar</creatorcontrib><creatorcontrib>Solomon, Thomas P.J.</creatorcontrib><creatorcontrib>Hwang, Calvin</creatorcontrib><creatorcontrib>Huang, Hazel</creatorcontrib><creatorcontrib>Haus, Jacob M.</creatorcontrib><creatorcontrib>Zhang, Renliang</creatorcontrib><creatorcontrib>Kirwan, John P.</creatorcontrib><title>Improved insulin sensitivity after exercise training is linked to reduced plasma C14:0 ceramide in obesity and type 2 diabetes</title><title>Obesity (Silver Spring, Md.)</title><addtitle>Obesity (Silver Spring)</addtitle><description>Objective
To assess the effect of exercise training on insulin sensitivity and plasma ceramides in obesity and type 2 diabetes (T2D).
Methods
Twenty‐four adults with obesity and normal glucose tolerance (NGT, n = 14) or diabetes (n = 10) were studied before and after a 12‐week supervised exercise‐training program (5 days/week, 1 h/day, 80‐85% of maximum heart rate). Changes in body composition were assessed using hydrostatic weighing and computed tomography. Peripheral tissue insulin sensitivity was assessed by a 40 mU/m2/min hyperinsulinemic euglycemic clamp. Plasma ceramides (C14:0, C16:0, C18:0, C18:1, C20:0, C24:0, and C24:1) were quantified using electrospray ionization tandem mass spectrometry after separation with HPLC.
Results
Plasma ceramides were similar for the subjects with obesity and NGT and the subjects with diabetes, despite differences in glucose tolerance. Exercise significantly reduced body weight and adiposity and increased peripheral insulin sensitivity in both groups (P < 0.05). In addition, plasma C14:0, C16:0, C18:1, and C24:0 ceramide levels were reduced in all subjects following the intervention (P < 0.05). Decreases in total (r = −0.51, P = 0.02) and C14:0 (r = −0.56, P = 0.009) ceramide were negatively correlated with the increase in insulin sensitivity.
Conclusions
Ceramides are linked to exercise training‐induced improvements in insulin sensitivity, and plasma C14:0 ceramide may provide a specific target for investigating lipid‐related insulin resistance in obesity and T2D.</description><subject>Adult</subject><subject>Body Composition</subject><subject>Body Weight</subject><subject>Ceramides - blood</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - therapy</subject><subject>Exercise</subject><subject>Exercise - physiology</subject><subject>Female</subject><subject>Glucose</subject><subject>Humans</subject><subject>Hyperglycemia</subject><subject>Insulin</subject><subject>Insulin resistance</subject><subject>Insulin Resistance - physiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Obesity</subject><subject>Obesity - blood</subject><subject>Obesity - therapy</subject><subject>Physical Endurance - physiology</subject><subject>Plasma</subject><subject>Rodents</subject><subject>Weight control</subject><issn>1930-7381</issn><issn>1930-739X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkU1v1DAQhi0EoqVw4A8gS1y4bOuxHXvNAams-KhUqReQ4GQ5zmxxSexgJwu58Nsx27ICTn6lefxoRi8hT4GdAmP8LLXLKQcAfY8cgxFspYX5dP-Q13BEHpVyw5hUrIGH5Ig3RimhxDH5eTGMOe2woyGWuQ-RFowlTGEXpoW67YSZ4g_MPhSkU3YhhnhNQ6EV_Vp_TYlm7GZf49i7Mji6AfmSUY_ZDaHDqqWpxbK3xcovI1JOu-BanLA8Jg-2ri_45O49IR_fvvmweb-6vHp3sTm_XHmpjV51DXhjlOw4A44GvRHKIV933OhGQSsUSi-UbBuNgFvuW2W2TAouW5BetuKEvLr1jnM7YOcx1lt6O-YwuLzY5IL9dxLDF3uddlbKNddaVMGLO0FO32Yskx1C8dj3LmKaiwVloDFrqVlFn_-H3qQ5x3qeBc24YUZAU6lnf290WOVPNRU4uwW-hx6XwxyY_d25rZ3bfef26vXnfRC_AOYhn4w</recordid><startdate>201507</startdate><enddate>201507</enddate><creator>Kasumov, Takhar</creator><creator>Solomon, Thomas P.J.</creator><creator>Hwang, Calvin</creator><creator>Huang, Hazel</creator><creator>Haus, Jacob M.</creator><creator>Zhang, Renliang</creator><creator>Kirwan, John P.</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201507</creationdate><title>Improved insulin sensitivity after exercise training is linked to reduced plasma C14:0 ceramide in obesity and type 2 diabetes</title><author>Kasumov, Takhar ; Solomon, Thomas P.J. ; Hwang, Calvin ; Huang, Hazel ; Haus, Jacob M. ; Zhang, Renliang ; Kirwan, John P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4797-d51c9964d2012e9ec936ae28d297561b36e4c364b57e1ef2cb69f04324b14c4b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Body Composition</topic><topic>Body Weight</topic><topic>Ceramides - blood</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes Mellitus, Type 2 - therapy</topic><topic>Exercise</topic><topic>Exercise - physiology</topic><topic>Female</topic><topic>Glucose</topic><topic>Humans</topic><topic>Hyperglycemia</topic><topic>Insulin</topic><topic>Insulin resistance</topic><topic>Insulin Resistance - physiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Obesity</topic><topic>Obesity - blood</topic><topic>Obesity - therapy</topic><topic>Physical Endurance - physiology</topic><topic>Plasma</topic><topic>Rodents</topic><topic>Weight control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kasumov, Takhar</creatorcontrib><creatorcontrib>Solomon, Thomas P.J.</creatorcontrib><creatorcontrib>Hwang, Calvin</creatorcontrib><creatorcontrib>Huang, Hazel</creatorcontrib><creatorcontrib>Haus, Jacob M.</creatorcontrib><creatorcontrib>Zhang, Renliang</creatorcontrib><creatorcontrib>Kirwan, John P.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Obesity (Silver Spring, Md.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kasumov, Takhar</au><au>Solomon, Thomas P.J.</au><au>Hwang, Calvin</au><au>Huang, Hazel</au><au>Haus, Jacob M.</au><au>Zhang, Renliang</au><au>Kirwan, John P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Improved insulin sensitivity after exercise training is linked to reduced plasma C14:0 ceramide in obesity and type 2 diabetes</atitle><jtitle>Obesity (Silver Spring, Md.)</jtitle><addtitle>Obesity (Silver Spring)</addtitle><date>2015-07</date><risdate>2015</risdate><volume>23</volume><issue>7</issue><spage>1414</spage><epage>1421</epage><pages>1414-1421</pages><issn>1930-7381</issn><eissn>1930-739X</eissn><abstract>Objective
To assess the effect of exercise training on insulin sensitivity and plasma ceramides in obesity and type 2 diabetes (T2D).
Methods
Twenty‐four adults with obesity and normal glucose tolerance (NGT, n = 14) or diabetes (n = 10) were studied before and after a 12‐week supervised exercise‐training program (5 days/week, 1 h/day, 80‐85% of maximum heart rate). Changes in body composition were assessed using hydrostatic weighing and computed tomography. Peripheral tissue insulin sensitivity was assessed by a 40 mU/m2/min hyperinsulinemic euglycemic clamp. Plasma ceramides (C14:0, C16:0, C18:0, C18:1, C20:0, C24:0, and C24:1) were quantified using electrospray ionization tandem mass spectrometry after separation with HPLC.
Results
Plasma ceramides were similar for the subjects with obesity and NGT and the subjects with diabetes, despite differences in glucose tolerance. Exercise significantly reduced body weight and adiposity and increased peripheral insulin sensitivity in both groups (P < 0.05). In addition, plasma C14:0, C16:0, C18:1, and C24:0 ceramide levels were reduced in all subjects following the intervention (P < 0.05). Decreases in total (r = −0.51, P = 0.02) and C14:0 (r = −0.56, P = 0.009) ceramide were negatively correlated with the increase in insulin sensitivity.
Conclusions
Ceramides are linked to exercise training‐induced improvements in insulin sensitivity, and plasma C14:0 ceramide may provide a specific target for investigating lipid‐related insulin resistance in obesity and T2D.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>25966363</pmid><doi>10.1002/oby.21117</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | Wiley Free Content; MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Body Composition Body Weight Ceramides - blood Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - therapy Exercise Exercise - physiology Female Glucose Humans Hyperglycemia Insulin Insulin resistance Insulin Resistance - physiology Male Middle Aged Obesity Obesity - blood Obesity - therapy Physical Endurance - physiology Plasma Rodents Weight control |
| title | Improved insulin sensitivity after exercise training is linked to reduced plasma C14:0 ceramide in obesity and type 2 diabetes |
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