Can an Intensive Diet and Exercise Program Prevent Knee Pain Among Overweight Adults at High Risk?
Objective It is unclear whether an intensive program of weight loss combined with exercise prevents the onset of knee pain among those at high risk. We examined whether an intensive lifestyle intervention (ILI) prevents incident knee pain compared with a diabetes mellitus support and education (DSE)...
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| Veröffentlicht in: | Arthritis care & research (2010) 2015-07, Vol.67 (7), p.965-971 |
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| container_title | Arthritis care & research (2010) |
| container_volume | 67 |
| creator | White, Daniel K. Neogi, Tuhina Rejeski, W. Jack Walkup, Michael P. Lewis, Cora E. Nevitt, Michael C. Foy, Capri G. Felson, David T. |
| description | Objective
It is unclear whether an intensive program of weight loss combined with exercise prevents the onset of knee pain among those at high risk. We examined whether an intensive lifestyle intervention (ILI) prevents incident knee pain compared with a diabetes mellitus support and education (DSE) comparison group among overweight adults with diabetes mellitus.
Methods
We conducted a secondary analysis of the Action for Health in Diabetes (Look AHEAD) study, which is a randomized intervention trial of adults who were obese and had type 2 diabetes mellitus starting in 2001. We studied a subcohort of 2,889 subjects who reported no knee pain at baseline but were at high risk due to obesity. Risk ratios (RRs) were calculated to examine the association of ILI versus DSE with incident knee pain at year 1 and year 4. All analyses were adjusted for potential confounders.
Results
Age, sex, and body mass index were similar among ILI and DSE participants with no knee pain at baseline. At year 1, ILI participants were 15% less likely to develop knee pain compared with DSE participants (RR 0.85, 95% confidence interval 0.74–0.98). At year 4, this difference decreased to 5% and was no longer statistically significant.
Conclusion
An ILI of diet and exercise may prevent the development of knee pain among those at high risk in the short term. Health care providers may consider recommending diet and exercise as a means to prevent the development of knee pain among those at high risk. |
| doi_str_mv | 10.1002/acr.22544 |
| format | Article |
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It is unclear whether an intensive program of weight loss combined with exercise prevents the onset of knee pain among those at high risk. We examined whether an intensive lifestyle intervention (ILI) prevents incident knee pain compared with a diabetes mellitus support and education (DSE) comparison group among overweight adults with diabetes mellitus.
Methods
We conducted a secondary analysis of the Action for Health in Diabetes (Look AHEAD) study, which is a randomized intervention trial of adults who were obese and had type 2 diabetes mellitus starting in 2001. We studied a subcohort of 2,889 subjects who reported no knee pain at baseline but were at high risk due to obesity. Risk ratios (RRs) were calculated to examine the association of ILI versus DSE with incident knee pain at year 1 and year 4. All analyses were adjusted for potential confounders.
Results
Age, sex, and body mass index were similar among ILI and DSE participants with no knee pain at baseline. At year 1, ILI participants were 15% less likely to develop knee pain compared with DSE participants (RR 0.85, 95% confidence interval 0.74–0.98). At year 4, this difference decreased to 5% and was no longer statistically significant.
Conclusion
An ILI of diet and exercise may prevent the development of knee pain among those at high risk in the short term. Health care providers may consider recommending diet and exercise as a means to prevent the development of knee pain among those at high risk.</description><identifier>ISSN: 2151-464X</identifier><identifier>EISSN: 2151-4658</identifier><identifier>DOI: 10.1002/acr.22544</identifier><identifier>PMID: 25692781</identifier><language>eng</language><publisher>United States</publisher><subject>Aged ; Body Mass Index ; Caloric Restriction - methods ; Cohort Studies ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - diagnosis ; Diabetes Mellitus, Type 2 - therapy ; Diet - methods ; Exercise - physiology ; Exercise Therapy - methods ; Female ; Humans ; Knee Joint - pathology ; Male ; Middle Aged ; Overweight - complications ; Overweight - diagnosis ; Overweight - therapy ; Pain - diagnosis ; Pain - etiology ; Pain Management - methods ; Risk Factors ; Risk Reduction Behavior ; Weight Loss - physiology</subject><ispartof>Arthritis care & research (2010), 2015-07, Vol.67 (7), p.965-971</ispartof><rights>2015, American College of Rheumatology</rights><rights>2015, American College of Rheumatology.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4484-bbfdb1aef7b4a622bf60314ffe790950982bb557fe82722a3bb03b57a1873f333</citedby><cites>FETCH-LOGICAL-c4484-bbfdb1aef7b4a622bf60314ffe790950982bb557fe82722a3bb03b57a1873f333</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Facr.22544$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Facr.22544$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,778,782,883,1414,27911,27912,45561,45562</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25692781$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>White, Daniel K.</creatorcontrib><creatorcontrib>Neogi, Tuhina</creatorcontrib><creatorcontrib>Rejeski, W. Jack</creatorcontrib><creatorcontrib>Walkup, Michael P.</creatorcontrib><creatorcontrib>Lewis, Cora E.</creatorcontrib><creatorcontrib>Nevitt, Michael C.</creatorcontrib><creatorcontrib>Foy, Capri G.</creatorcontrib><creatorcontrib>Felson, David T.</creatorcontrib><creatorcontrib>Look AHEAD Research Group</creatorcontrib><creatorcontrib>for the Look AHEAD Research Group</creatorcontrib><title>Can an Intensive Diet and Exercise Program Prevent Knee Pain Among Overweight Adults at High Risk?</title><title>Arthritis care & research (2010)</title><addtitle>Arthritis Care Res (Hoboken)</addtitle><description>Objective
It is unclear whether an intensive program of weight loss combined with exercise prevents the onset of knee pain among those at high risk. We examined whether an intensive lifestyle intervention (ILI) prevents incident knee pain compared with a diabetes mellitus support and education (DSE) comparison group among overweight adults with diabetes mellitus.
Methods
We conducted a secondary analysis of the Action for Health in Diabetes (Look AHEAD) study, which is a randomized intervention trial of adults who were obese and had type 2 diabetes mellitus starting in 2001. We studied a subcohort of 2,889 subjects who reported no knee pain at baseline but were at high risk due to obesity. Risk ratios (RRs) were calculated to examine the association of ILI versus DSE with incident knee pain at year 1 and year 4. All analyses were adjusted for potential confounders.
Results
Age, sex, and body mass index were similar among ILI and DSE participants with no knee pain at baseline. At year 1, ILI participants were 15% less likely to develop knee pain compared with DSE participants (RR 0.85, 95% confidence interval 0.74–0.98). At year 4, this difference decreased to 5% and was no longer statistically significant.
Conclusion
An ILI of diet and exercise may prevent the development of knee pain among those at high risk in the short term. Health care providers may consider recommending diet and exercise as a means to prevent the development of knee pain among those at high risk.</description><subject>Aged</subject><subject>Body Mass Index</subject><subject>Caloric Restriction - methods</subject><subject>Cohort Studies</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetes Mellitus, Type 2 - diagnosis</subject><subject>Diabetes Mellitus, Type 2 - therapy</subject><subject>Diet - methods</subject><subject>Exercise - physiology</subject><subject>Exercise Therapy - methods</subject><subject>Female</subject><subject>Humans</subject><subject>Knee Joint - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Overweight - complications</subject><subject>Overweight - diagnosis</subject><subject>Overweight - therapy</subject><subject>Pain - diagnosis</subject><subject>Pain - etiology</subject><subject>Pain Management - methods</subject><subject>Risk Factors</subject><subject>Risk Reduction Behavior</subject><subject>Weight Loss - physiology</subject><issn>2151-464X</issn><issn>2151-4658</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1PGzEQhi1URFDKgT9Q-dgeEvy1a--lVRQoREUCIZC4WfZmHNzuesHeBPj3NQQiOCCskcYzfvR67BehfUrGlBB2YOo4ZqwQYgvtMlrQkSgL9WWzF9cDtJfSX5IXZ0rxagcNWFFWTCq6i-zUBJxjFnoIya8AH3roc2eOjx4g1j4BPo_dIpo2Z1hB6PGfALlpfMCTtgsLfLaCeA9-cdPjyXzZ9AmbHp_kGl_49O_XV7TtTJNg7yUP0dXvo8vpyej07Hg2nZyOaiGUGFnr5pYacNIKUzJmXUk4Fc6BrEhVkEoxa4tCOlBMMma4tYTbQhqqJHec8yH6uda9XdoW5nUeNZpG30bfmvioO-P1-5Pgb_SiW-l8PZOSZYHvLwKxu1tC6nXrUw1NYwJ0y6SpJFRU-VvJ52iZuUqWqszojzVaxy6lCG4zESX6yUGdHdTPDmb229snbMhXvzJwsAbufQOPHyvpyfRiLfkfvOmkrg</recordid><startdate>201507</startdate><enddate>201507</enddate><creator>White, Daniel K.</creator><creator>Neogi, Tuhina</creator><creator>Rejeski, W. Jack</creator><creator>Walkup, Michael P.</creator><creator>Lewis, Cora E.</creator><creator>Nevitt, Michael C.</creator><creator>Foy, Capri G.</creator><creator>Felson, David T.</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TS</scope><scope>5PM</scope></search><sort><creationdate>201507</creationdate><title>Can an Intensive Diet and Exercise Program Prevent Knee Pain Among Overweight Adults at High Risk?</title><author>White, Daniel K. ; Neogi, Tuhina ; Rejeski, W. Jack ; Walkup, Michael P. ; Lewis, Cora E. ; Nevitt, Michael C. ; Foy, Capri G. ; Felson, David T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4484-bbfdb1aef7b4a622bf60314ffe790950982bb557fe82722a3bb03b57a1873f333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>Body Mass Index</topic><topic>Caloric Restriction - methods</topic><topic>Cohort Studies</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetes Mellitus, Type 2 - diagnosis</topic><topic>Diabetes Mellitus, Type 2 - therapy</topic><topic>Diet - methods</topic><topic>Exercise - physiology</topic><topic>Exercise Therapy - methods</topic><topic>Female</topic><topic>Humans</topic><topic>Knee Joint - pathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Overweight - complications</topic><topic>Overweight - diagnosis</topic><topic>Overweight - therapy</topic><topic>Pain - diagnosis</topic><topic>Pain - etiology</topic><topic>Pain Management - methods</topic><topic>Risk Factors</topic><topic>Risk Reduction Behavior</topic><topic>Weight Loss - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>White, Daniel K.</creatorcontrib><creatorcontrib>Neogi, Tuhina</creatorcontrib><creatorcontrib>Rejeski, W. Jack</creatorcontrib><creatorcontrib>Walkup, Michael P.</creatorcontrib><creatorcontrib>Lewis, Cora E.</creatorcontrib><creatorcontrib>Nevitt, Michael C.</creatorcontrib><creatorcontrib>Foy, Capri G.</creatorcontrib><creatorcontrib>Felson, David T.</creatorcontrib><creatorcontrib>Look AHEAD Research Group</creatorcontrib><creatorcontrib>for the Look AHEAD Research Group</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Physical Education Index</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Arthritis care & research (2010)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>White, Daniel K.</au><au>Neogi, Tuhina</au><au>Rejeski, W. Jack</au><au>Walkup, Michael P.</au><au>Lewis, Cora E.</au><au>Nevitt, Michael C.</au><au>Foy, Capri G.</au><au>Felson, David T.</au><aucorp>Look AHEAD Research Group</aucorp><aucorp>for the Look AHEAD Research Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Can an Intensive Diet and Exercise Program Prevent Knee Pain Among Overweight Adults at High Risk?</atitle><jtitle>Arthritis care & research (2010)</jtitle><addtitle>Arthritis Care Res (Hoboken)</addtitle><date>2015-07</date><risdate>2015</risdate><volume>67</volume><issue>7</issue><spage>965</spage><epage>971</epage><pages>965-971</pages><issn>2151-464X</issn><eissn>2151-4658</eissn><abstract>Objective
It is unclear whether an intensive program of weight loss combined with exercise prevents the onset of knee pain among those at high risk. We examined whether an intensive lifestyle intervention (ILI) prevents incident knee pain compared with a diabetes mellitus support and education (DSE) comparison group among overweight adults with diabetes mellitus.
Methods
We conducted a secondary analysis of the Action for Health in Diabetes (Look AHEAD) study, which is a randomized intervention trial of adults who were obese and had type 2 diabetes mellitus starting in 2001. We studied a subcohort of 2,889 subjects who reported no knee pain at baseline but were at high risk due to obesity. Risk ratios (RRs) were calculated to examine the association of ILI versus DSE with incident knee pain at year 1 and year 4. All analyses were adjusted for potential confounders.
Results
Age, sex, and body mass index were similar among ILI and DSE participants with no knee pain at baseline. At year 1, ILI participants were 15% less likely to develop knee pain compared with DSE participants (RR 0.85, 95% confidence interval 0.74–0.98). At year 4, this difference decreased to 5% and was no longer statistically significant.
Conclusion
An ILI of diet and exercise may prevent the development of knee pain among those at high risk in the short term. Health care providers may consider recommending diet and exercise as a means to prevent the development of knee pain among those at high risk.</abstract><cop>United States</cop><pmid>25692781</pmid><doi>10.1002/acr.22544</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2151-464X |
| ispartof | Arthritis care & research (2010), 2015-07, Vol.67 (7), p.965-971 |
| issn | 2151-464X 2151-4658 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Aged Body Mass Index Caloric Restriction - methods Cohort Studies Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - diagnosis Diabetes Mellitus, Type 2 - therapy Diet - methods Exercise - physiology Exercise Therapy - methods Female Humans Knee Joint - pathology Male Middle Aged Overweight - complications Overweight - diagnosis Overweight - therapy Pain - diagnosis Pain - etiology Pain Management - methods Risk Factors Risk Reduction Behavior Weight Loss - physiology |
| title | Can an Intensive Diet and Exercise Program Prevent Knee Pain Among Overweight Adults at High Risk? |
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