Rituximab-Induced Acute ST Elevation Myocardial Infarction
Rituximab has rarely been associated with acute coronary syndrome (ACS). We report the case of a patient in whom rituximab, a monoclonal antibody used to treat lymphomas of B-cell origin, induced ST elevation myocardial infarction. A 46-year-old male patient diagnosed with stage II non-Hodgkin lymph...
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| Veröffentlicht in: | The Ochsner journal 2015, Vol.15 (2), p.187-190 |
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| creator | Keswani, Amit N Williams, Cody Fuloria, Jyotsna Polin, Nichole M Jahangir, Eiman |
| description | Rituximab has rarely been associated with acute coronary syndrome (ACS). We report the case of a patient in whom rituximab, a monoclonal antibody used to treat lymphomas of B-cell origin, induced ST elevation myocardial infarction.
A 46-year-old male patient diagnosed with stage II non-Hodgkin lymphoma presented to the emergency department with acute crushing, substernal chest pain that radiated to his back 1 day after a chemotherapy infusion with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone. An electrocardiogram revealed normal sinus rhythm with ST elevations in the inferior leads. The patient underwent primary percutaneous coronary intervention (PCI) of his right coronary artery and first diagonal artery with placement of drug-eluting stents. He did well postprocedure and resumed therapy with rituximab under close monitoring by the cardiology and oncology departments without any further cardiac events.
In patients with ACS because of chemotherapy, complete revascularization during PCI should be considered. |
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A 46-year-old male patient diagnosed with stage II non-Hodgkin lymphoma presented to the emergency department with acute crushing, substernal chest pain that radiated to his back 1 day after a chemotherapy infusion with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone. An electrocardiogram revealed normal sinus rhythm with ST elevations in the inferior leads. The patient underwent primary percutaneous coronary intervention (PCI) of his right coronary artery and first diagonal artery with placement of drug-eluting stents. He did well postprocedure and resumed therapy with rituximab under close monitoring by the cardiology and oncology departments without any further cardiac events.
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A 46-year-old male patient diagnosed with stage II non-Hodgkin lymphoma presented to the emergency department with acute crushing, substernal chest pain that radiated to his back 1 day after a chemotherapy infusion with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone. An electrocardiogram revealed normal sinus rhythm with ST elevations in the inferior leads. The patient underwent primary percutaneous coronary intervention (PCI) of his right coronary artery and first diagonal artery with placement of drug-eluting stents. He did well postprocedure and resumed therapy with rituximab under close monitoring by the cardiology and oncology departments without any further cardiac events.
In patients with ACS because of chemotherapy, complete revascularization during PCI should be considered.</description><subject>Acute coronary syndromes</subject><subject>Cardiac arrhythmia</subject><subject>Cardiology</subject><subject>Cardiovascular disease</subject><subject>Case Reports and Clinical Observations</subject><subject>Chemotherapy</subject><subject>Coronary vessels</subject><subject>Dyspnea</subject><subject>Electrocardiography</subject><subject>Family medical history</subject><subject>Heart attacks</subject><subject>Hypertension</subject><subject>Immunotherapy</subject><subject>Intubation</subject><subject>Laboratories</subject><subject>Lymphoma</subject><subject>Monoclonal antibodies</subject><subject>Patients</subject><subject>Stents</subject><subject>Systematic review</subject><subject>Targeted cancer therapy</subject><subject>Ultrasonic imaging</subject><subject>Vital signs</subject><issn>1524-5012</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpVkFFLwzAUhfOguDn9C1LwudCkN03qgzDG1MJE0PkcbtJEO7q2pulw_94Op-jTgXsP3zmcEzKlnEHME8om5LzvN0kCCQd2RiYso2mSS5iSm-cqDJ_VFnVcNOVgbBnNzRBs9LKOlrXdYajaJnrctwZ9WWEdFY1Dbw7XC3LqsO7t5VFn5PVuuV48xKun-2IxX8XdGBNiJ6wATZ3JtZCWo2ZcQ8Y5JsJJYQ0FR7V2BgU4iTbXgFoLNHma2dSYNJ2R229uN-itLY1tgsdadX5s7feqxUr9_zTVu3prdwpAMp4dANdHgG8_BtsHtWkH34ydFaNcMgqQ5aPr6m_ML_9nq_QLk5dmKg</recordid><startdate>2015</startdate><enddate>2015</enddate><creator>Keswani, Amit N</creator><creator>Williams, Cody</creator><creator>Fuloria, Jyotsna</creator><creator>Polin, Nichole M</creator><creator>Jahangir, Eiman</creator><general>Ochsner Clinic Foundation Academic Center - Publishing Services</general><general>the Academic Division of Ochsner Clinic Foundation</general><scope>NPM</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope></search><sort><creationdate>2015</creationdate><title>Rituximab-Induced Acute ST Elevation Myocardial Infarction</title><author>Keswani, Amit N ; Williams, Cody ; Fuloria, Jyotsna ; Polin, Nichole M ; Jahangir, Eiman</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p261t-f7e74b1fc9b78e5ab25b4655a07f87ec14f1bbfca74f8ae9b4abb7ac936e3cc33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Acute coronary syndromes</topic><topic>Cardiac arrhythmia</topic><topic>Cardiology</topic><topic>Cardiovascular disease</topic><topic>Case Reports and Clinical Observations</topic><topic>Chemotherapy</topic><topic>Coronary vessels</topic><topic>Dyspnea</topic><topic>Electrocardiography</topic><topic>Family medical history</topic><topic>Heart attacks</topic><topic>Hypertension</topic><topic>Immunotherapy</topic><topic>Intubation</topic><topic>Laboratories</topic><topic>Lymphoma</topic><topic>Monoclonal antibodies</topic><topic>Patients</topic><topic>Stents</topic><topic>Systematic review</topic><topic>Targeted cancer therapy</topic><topic>Ultrasonic imaging</topic><topic>Vital signs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Keswani, Amit N</creatorcontrib><creatorcontrib>Williams, Cody</creatorcontrib><creatorcontrib>Fuloria, Jyotsna</creatorcontrib><creatorcontrib>Polin, Nichole M</creatorcontrib><creatorcontrib>Jahangir, Eiman</creatorcontrib><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Nursing & Allied Health Premium</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Ochsner journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Keswani, Amit N</au><au>Williams, Cody</au><au>Fuloria, Jyotsna</au><au>Polin, Nichole M</au><au>Jahangir, Eiman</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rituximab-Induced Acute ST Elevation Myocardial Infarction</atitle><jtitle>The Ochsner journal</jtitle><addtitle>Ochsner J</addtitle><date>2015</date><risdate>2015</risdate><volume>15</volume><issue>2</issue><spage>187</spage><epage>190</epage><pages>187-190</pages><issn>1524-5012</issn><abstract>Rituximab has rarely been associated with acute coronary syndrome (ACS). We report the case of a patient in whom rituximab, a monoclonal antibody used to treat lymphomas of B-cell origin, induced ST elevation myocardial infarction.
A 46-year-old male patient diagnosed with stage II non-Hodgkin lymphoma presented to the emergency department with acute crushing, substernal chest pain that radiated to his back 1 day after a chemotherapy infusion with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone. An electrocardiogram revealed normal sinus rhythm with ST elevations in the inferior leads. The patient underwent primary percutaneous coronary intervention (PCI) of his right coronary artery and first diagonal artery with placement of drug-eluting stents. He did well postprocedure and resumed therapy with rituximab under close monitoring by the cardiology and oncology departments without any further cardiac events.
In patients with ACS because of chemotherapy, complete revascularization during PCI should be considered.</abstract><cop>United States</cop><pub>Ochsner Clinic Foundation Academic Center - Publishing Services</pub><pmid>26130984</pmid><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Acute coronary syndromes Cardiac arrhythmia Cardiology Cardiovascular disease Case Reports and Clinical Observations Chemotherapy Coronary vessels Dyspnea Electrocardiography Family medical history Heart attacks Hypertension Immunotherapy Intubation Laboratories Lymphoma Monoclonal antibodies Patients Stents Systematic review Targeted cancer therapy Ultrasonic imaging Vital signs |
| title | Rituximab-Induced Acute ST Elevation Myocardial Infarction |
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