Lysophosphatidic acid transactivates both c-Met and epidermal growth factor receptor, and induces cyclooxygenase-2 expression in human colon cancer LoVo cells

AIM： To examine whether lysophosphatidic acid （LPA） induces phosphorylation of c-Met and epidermal growth factor receptor （EGFR）, both of which have been proposed as prognostic markers of colorectal cancer, and whether LPA induces cyclooxygenase-2 （COX-2） expression in human colon cancer cells. METH...

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Veröffentlicht in:	World journal of gastroenterology : WJG 2005-09, Vol.11 (36), p.5638-5643
Hauptverfasser:	Shida, Dai, Kitayama, Joji, Yamaguchi, Hironori, Yamashita, Hiroharu, Mori, Ken, Watanabe, Toshiaki, Nagawa, Hirokazu
Format:	Artikel
Sprache:	eng
Schlagworte:	c-Met Cell Line, Tumor Colonic Neoplasms - enzymology Colonic Neoplasms - metabolism Colorectal Cancer Cyclooxygenase 2 - metabolism Cyclooxygenase Inhibitors - pharmacology Enzyme Induction - drug effects ErbB Receptors - metabolism Gene Expression Regulation, Neoplastic - drug effects Humans Lysophospholipids - pharmacology Nitrobenzenes - metabolism Phosphorylation Proto-Oncogene Proteins c-met - metabolism Signal Transduction Sulfonamides - metabolism Transcriptional Activation - drug effects Up-Regulation - drug effects 基因表达环氧合酶-2 结肠癌表皮生长因子受体
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