Stoichiometry of Heteromeric BAFF and APRIL Cytokines Dictates Their Receptor Binding and Signaling Properties

The closely related TNF family ligands B cell activation factor (BAFF) and aproliferation-inducing ligand (APRIL) serve in the generation and maintenance of mature B-lymphocytes. Both BAFF and APRIL assemble as homotrimers that bind and activate several receptors that they partially share. However,...

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Veröffentlicht in:	The Journal of biological chemistry 2015-06, Vol.290 (26), p.16330-16342
Hauptverfasser:	Schuepbach-Mallepell, Sonia, Das, Dolon, Willen, Laure, Vigolo, Michele, Tardivel, Aubry, Lebon, Luc, Kowalczyk-Quintas, Christine, Nys, Josquin, Smulski, Cristian, Zheng, Timothy S., Maskos, Klaus, Lammens, Alfred, Jiang, Xuliang, Hess, Henry, Tan, Seng-Lai, Schneider, Pascal
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals APRIL B-Cell Activating Factor - chemistry B-Cell Activating Factor - genetics B-Cell Activating Factor - metabolism B-Cell Activation Factor Receptor - genetics B-Cell Activation Factor Receptor - metabolism B-Cell Maturation Antigen - genetics B-Cell Maturation Antigen - metabolism BAFF cytokine Dimerization heteromers Humans Immunology Ligands Mice Mice, Inbred C57BL Models, Molecular Protein Binding protein engineering receptor Signal Transduction signaling Transmembrane Activator and CAML Interactor Protein - genetics Transmembrane Activator and CAML Interactor Protein - metabolism Tumor Necrosis Factor Ligand Superfamily Member 13 - chemistry Tumor Necrosis Factor Ligand Superfamily Member 13 - genetics Tumor Necrosis Factor Ligand Superfamily Member 13 - metabolism
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