Epicardial fat thickness in patients with rheumatoid arthritis
Background: Epidemiologic data indicates that rheumatoid arthritis is an independent risk factor for cardiovascular disease. Epicardial adipose tissue is a novel cardio-metabolic risk factor. Our aim was to evaluate epicardial fat thickness (EFT) using echocardiography in patients with rheumatoid ar...
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| Veröffentlicht in: | African health sciences 2015-06, Vol.15 (2), p.489-495 |
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| creator | Fatma, Erdem Bünyamin, Koç Savas, Sarikaya Mehmet, Uçar Selma, Yazıcı Ismail, Boyraz Sabri, Caglar Gulzade, Ozyalvacli Ibrahim, Dönmez Mehmet, Yazici |
| description | Background: Epidemiologic data indicates that rheumatoid arthritis is
an independent risk factor for cardiovascular disease. Epicardial
adipose tissue is a novel cardio-metabolic risk factor. Our aim was to
evaluate epicardial fat thickness (EFT) using echocardiography in
patients with rheumatoid arthritis compared to healthy control
subjects. Secondly, we investigated relationship between epicardial fat
thickness and clinical and echocardiographic parameters in patients
with rheumatoid arthritis. Method: The study population included 76
consecutive patients with rheumatoid arthritis (64 female; mean age, 53
±11 years, median disease duration, 7.8 years) and 50 healthy
subjects as controls (39 female; mean age, 52 ± 6 years). All
patients underwent echocardiography to assess left ventricular
diastolic dysfunction, left ventricular hypertrophy and EFT. All values
were compared between groups. Results: EFT was higher in rheumatoid
arthritis patients than in healthy controls (0.66±0.20 vs.
0.54±0.18; p= 0.003). Thickness of Intra Ventricular Septum (IVS)
(1.1±0.06 and 9.8±0.08; p=0.001) and posterior wall (PW)
(0.98±0.05 and 0.93±0.08; p=0.015) was higher in patients
with rheumatoid arthritis compared to healthy controls. Early diastolic
myocardiac peak velocity or late diastolic mitral peak velocity (E/A)
ratio was lower in rheumatoid arthritis patients compared to healthy
patients (1.1 ±0.8 and 1.24±0.1 p=0.001) as well as,
E/e' was higher in Rheumatoid arthritis (RA) patients than
healthy patients. (E/e':8.7±1.6 and 8.0±1.4 p=0.020).
In patients with rheumatoid arthritis, EFT was positively correlated
with hypertension and duration of disease and E/e' (r: 0.10, p:
0.010, r: 0.306, p: 0.004 and r: 0.465 p: 0.007 respectively) and EFT
was negatively correlated with E/A (r: -.262 p:0.022 ) Conclusion: To
our knowledge, this is the first report about epicardial adipose tissue
in rheumatoid arthritis patients. Epicardial fat thickness as an
indicator of cardiovascular involvement was higher in rheumatoid
arthritis patients. |
| doi_str_mv | 10.4314/ahs.v15i2.23 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4480478</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1692755101</sourcerecordid><originalsourceid>FETCH-LOGICAL-b385t-4db4ef88aa34d0a311833580ef6673d8fb53baa1a8c818073896a43468d776323</originalsourceid><addsrcrecordid>eNpVkEtPwzAQhC0E4lG4cUY5ciDBjh9xLpUQ4iVV4gJna5M4ZCFNiu0W8e8xtFRwmtXup9nREHLKaCY4E5fQ-WzFJOZZznfIISvyMqWS8t04K01TVVJ5QI68f6U0V6xk--Qgai6KUh6S6c0Ca3ANQp-0EJLQYf02WO8THJIFBLRD8MkHhi5xnV3OIYzYJOBC5zCgPyZ7LfTenmx0Qp5vb56u79PZ493D9dUsrbiWIRVNJWyrNQAXDQXOmOZcampbpQre6LaSvAJgoGvNNC24LhUILpRuikLxnE_IdO27WFZz29QxlYPeLBzOwX2aEdD8vwzYmZdxZYTQVBQ6GpxvDNz4vrQ-mDn62vY9DHZcesNUmRdSMsoierFGazd672y7fcOo-a7cxMrNT-Um5xE_-xttC_92HIFsDVQ49jjYLVE7BPO7jJadZ5Kqkn8BoJSPJg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1692755101</pqid></control><display><type>article</type><title>Epicardial fat thickness in patients with rheumatoid arthritis</title><source>MEDLINE</source><source>African Journals Online (Open Access)</source><source>Bioline International</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Fatma, Erdem ; Bünyamin, Koç ; Savas, Sarikaya ; Mehmet, Uçar ; Selma, Yazıcı ; Ismail, Boyraz ; Sabri, Caglar ; Gulzade, Ozyalvacli ; Ibrahim, Dönmez ; Mehmet, Yazici</creator><creatorcontrib>Fatma, Erdem ; Bünyamin, Koç ; Savas, Sarikaya ; Mehmet, Uçar ; Selma, Yazıcı ; Ismail, Boyraz ; Sabri, Caglar ; Gulzade, Ozyalvacli ; Ibrahim, Dönmez ; Mehmet, Yazici</creatorcontrib><description>Background: Epidemiologic data indicates that rheumatoid arthritis is
an independent risk factor for cardiovascular disease. Epicardial
adipose tissue is a novel cardio-metabolic risk factor. Our aim was to
evaluate epicardial fat thickness (EFT) using echocardiography in
patients with rheumatoid arthritis compared to healthy control
subjects. Secondly, we investigated relationship between epicardial fat
thickness and clinical and echocardiographic parameters in patients
with rheumatoid arthritis. Method: The study population included 76
consecutive patients with rheumatoid arthritis (64 female; mean age, 53
±11 years, median disease duration, 7.8 years) and 50 healthy
subjects as controls (39 female; mean age, 52 ± 6 years). All
patients underwent echocardiography to assess left ventricular
diastolic dysfunction, left ventricular hypertrophy and EFT. All values
were compared between groups. Results: EFT was higher in rheumatoid
arthritis patients than in healthy controls (0.66±0.20 vs.
0.54±0.18; p= 0.003). Thickness of Intra Ventricular Septum (IVS)
(1.1±0.06 and 9.8±0.08; p=0.001) and posterior wall (PW)
(0.98±0.05 and 0.93±0.08; p=0.015) was higher in patients
with rheumatoid arthritis compared to healthy controls. Early diastolic
myocardiac peak velocity or late diastolic mitral peak velocity (E/A)
ratio was lower in rheumatoid arthritis patients compared to healthy
patients (1.1 ±0.8 and 1.24±0.1 p=0.001) as well as,
E/e' was higher in Rheumatoid arthritis (RA) patients than
healthy patients. (E/e':8.7±1.6 and 8.0±1.4 p=0.020).
In patients with rheumatoid arthritis, EFT was positively correlated
with hypertension and duration of disease and E/e' (r: 0.10, p:
0.010, r: 0.306, p: 0.004 and r: 0.465 p: 0.007 respectively) and EFT
was negatively correlated with E/A (r: -.262 p:0.022 ) Conclusion: To
our knowledge, this is the first report about epicardial adipose tissue
in rheumatoid arthritis patients. Epicardial fat thickness as an
indicator of cardiovascular involvement was higher in rheumatoid
arthritis patients.</description><identifier>ISSN: 1680-6905</identifier><identifier>EISSN: 1729-0503</identifier><identifier>EISSN: 1680-6905</identifier><identifier>DOI: 10.4314/ahs.v15i2.23</identifier><identifier>PMID: 26124795</identifier><language>eng</language><publisher>Uganda: Makerere University Medical School</publisher><subject>Adipose Tissue - diagnostic imaging ; Adipose Tissue - pathology ; Aged ; Arthritis, Rheumatoid - diagnostic imaging ; Arthritis, Rheumatoid - pathology ; cardiac involvement ; Case-Control Studies ; Diastole - physiology ; Echocardiography, Doppler ; epicardial fat thickness ; Female ; Heart - physiopathology ; Humans ; Hypertension - physiopathology ; Intra-Abdominal Fat - pathology ; Male ; Middle Aged ; Pericardium - diagnostic imaging ; Pericardium - pathology ; Rheumatoid arthritis ; Risk Factors ; Ventricular Dysfunction, Left - diagnostic imaging</subject><ispartof>African health sciences, 2015-06, Vol.15 (2), p.489-495</ispartof><rights>Copyright 2015 - African Health Sciences</rights><rights>Copyright © Makerere Medical School, Uganda 2015 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b385t-4db4ef88aa34d0a311833580ef6673d8fb53baa1a8c818073896a43468d776323</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480478/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480478/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792,79197</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26124795$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fatma, Erdem</creatorcontrib><creatorcontrib>Bünyamin, Koç</creatorcontrib><creatorcontrib>Savas, Sarikaya</creatorcontrib><creatorcontrib>Mehmet, Uçar</creatorcontrib><creatorcontrib>Selma, Yazıcı</creatorcontrib><creatorcontrib>Ismail, Boyraz</creatorcontrib><creatorcontrib>Sabri, Caglar</creatorcontrib><creatorcontrib>Gulzade, Ozyalvacli</creatorcontrib><creatorcontrib>Ibrahim, Dönmez</creatorcontrib><creatorcontrib>Mehmet, Yazici</creatorcontrib><title>Epicardial fat thickness in patients with rheumatoid arthritis</title><title>African health sciences</title><addtitle>Afr Health Sci</addtitle><description>Background: Epidemiologic data indicates that rheumatoid arthritis is
an independent risk factor for cardiovascular disease. Epicardial
adipose tissue is a novel cardio-metabolic risk factor. Our aim was to
evaluate epicardial fat thickness (EFT) using echocardiography in
patients with rheumatoid arthritis compared to healthy control
subjects. Secondly, we investigated relationship between epicardial fat
thickness and clinical and echocardiographic parameters in patients
with rheumatoid arthritis. Method: The study population included 76
consecutive patients with rheumatoid arthritis (64 female; mean age, 53
±11 years, median disease duration, 7.8 years) and 50 healthy
subjects as controls (39 female; mean age, 52 ± 6 years). All
patients underwent echocardiography to assess left ventricular
diastolic dysfunction, left ventricular hypertrophy and EFT. All values
were compared between groups. Results: EFT was higher in rheumatoid
arthritis patients than in healthy controls (0.66±0.20 vs.
0.54±0.18; p= 0.003). Thickness of Intra Ventricular Septum (IVS)
(1.1±0.06 and 9.8±0.08; p=0.001) and posterior wall (PW)
(0.98±0.05 and 0.93±0.08; p=0.015) was higher in patients
with rheumatoid arthritis compared to healthy controls. Early diastolic
myocardiac peak velocity or late diastolic mitral peak velocity (E/A)
ratio was lower in rheumatoid arthritis patients compared to healthy
patients (1.1 ±0.8 and 1.24±0.1 p=0.001) as well as,
E/e' was higher in Rheumatoid arthritis (RA) patients than
healthy patients. (E/e':8.7±1.6 and 8.0±1.4 p=0.020).
In patients with rheumatoid arthritis, EFT was positively correlated
with hypertension and duration of disease and E/e' (r: 0.10, p:
0.010, r: 0.306, p: 0.004 and r: 0.465 p: 0.007 respectively) and EFT
was negatively correlated with E/A (r: -.262 p:0.022 ) Conclusion: To
our knowledge, this is the first report about epicardial adipose tissue
in rheumatoid arthritis patients. Epicardial fat thickness as an
indicator of cardiovascular involvement was higher in rheumatoid
arthritis patients.</description><subject>Adipose Tissue - diagnostic imaging</subject><subject>Adipose Tissue - pathology</subject><subject>Aged</subject><subject>Arthritis, Rheumatoid - diagnostic imaging</subject><subject>Arthritis, Rheumatoid - pathology</subject><subject>cardiac involvement</subject><subject>Case-Control Studies</subject><subject>Diastole - physiology</subject><subject>Echocardiography, Doppler</subject><subject>epicardial fat thickness</subject><subject>Female</subject><subject>Heart - physiopathology</subject><subject>Humans</subject><subject>Hypertension - physiopathology</subject><subject>Intra-Abdominal Fat - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pericardium - diagnostic imaging</subject><subject>Pericardium - pathology</subject><subject>Rheumatoid arthritis</subject><subject>Risk Factors</subject><subject>Ventricular Dysfunction, Left - diagnostic imaging</subject><issn>1680-6905</issn><issn>1729-0503</issn><issn>1680-6905</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>RBI</sourceid><sourceid>EIF</sourceid><recordid>eNpVkEtPwzAQhC0E4lG4cUY5ciDBjh9xLpUQ4iVV4gJna5M4ZCFNiu0W8e8xtFRwmtXup9nREHLKaCY4E5fQ-WzFJOZZznfIISvyMqWS8t04K01TVVJ5QI68f6U0V6xk--Qgai6KUh6S6c0Ca3ANQp-0EJLQYf02WO8THJIFBLRD8MkHhi5xnV3OIYzYJOBC5zCgPyZ7LfTenmx0Qp5vb56u79PZ493D9dUsrbiWIRVNJWyrNQAXDQXOmOZcampbpQre6LaSvAJgoGvNNC24LhUILpRuikLxnE_IdO27WFZz29QxlYPeLBzOwX2aEdD8vwzYmZdxZYTQVBQ6GpxvDNz4vrQ-mDn62vY9DHZcesNUmRdSMsoierFGazd672y7fcOo-a7cxMrNT-Um5xE_-xttC_92HIFsDVQ49jjYLVE7BPO7jJadZ5Kqkn8BoJSPJg</recordid><startdate>20150601</startdate><enddate>20150601</enddate><creator>Fatma, Erdem</creator><creator>Bünyamin, Koç</creator><creator>Savas, Sarikaya</creator><creator>Mehmet, Uçar</creator><creator>Selma, Yazıcı</creator><creator>Ismail, Boyraz</creator><creator>Sabri, Caglar</creator><creator>Gulzade, Ozyalvacli</creator><creator>Ibrahim, Dönmez</creator><creator>Mehmet, Yazici</creator><general>Makerere University Medical School</general><general>Makerere Medical School</general><scope>RBI</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150601</creationdate><title>Epicardial fat thickness in patients with rheumatoid arthritis</title><author>Fatma, Erdem ; Bünyamin, Koç ; Savas, Sarikaya ; Mehmet, Uçar ; Selma, Yazıcı ; Ismail, Boyraz ; Sabri, Caglar ; Gulzade, Ozyalvacli ; Ibrahim, Dönmez ; Mehmet, Yazici</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b385t-4db4ef88aa34d0a311833580ef6673d8fb53baa1a8c818073896a43468d776323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adipose Tissue - diagnostic imaging</topic><topic>Adipose Tissue - pathology</topic><topic>Aged</topic><topic>Arthritis, Rheumatoid - diagnostic imaging</topic><topic>Arthritis, Rheumatoid - pathology</topic><topic>cardiac involvement</topic><topic>Case-Control Studies</topic><topic>Diastole - physiology</topic><topic>Echocardiography, Doppler</topic><topic>epicardial fat thickness</topic><topic>Female</topic><topic>Heart - physiopathology</topic><topic>Humans</topic><topic>Hypertension - physiopathology</topic><topic>Intra-Abdominal Fat - pathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pericardium - diagnostic imaging</topic><topic>Pericardium - pathology</topic><topic>Rheumatoid arthritis</topic><topic>Risk Factors</topic><topic>Ventricular Dysfunction, Left - diagnostic imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fatma, Erdem</creatorcontrib><creatorcontrib>Bünyamin, Koç</creatorcontrib><creatorcontrib>Savas, Sarikaya</creatorcontrib><creatorcontrib>Mehmet, Uçar</creatorcontrib><creatorcontrib>Selma, Yazıcı</creatorcontrib><creatorcontrib>Ismail, Boyraz</creatorcontrib><creatorcontrib>Sabri, Caglar</creatorcontrib><creatorcontrib>Gulzade, Ozyalvacli</creatorcontrib><creatorcontrib>Ibrahim, Dönmez</creatorcontrib><creatorcontrib>Mehmet, Yazici</creatorcontrib><collection>Bioline International</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>African health sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fatma, Erdem</au><au>Bünyamin, Koç</au><au>Savas, Sarikaya</au><au>Mehmet, Uçar</au><au>Selma, Yazıcı</au><au>Ismail, Boyraz</au><au>Sabri, Caglar</au><au>Gulzade, Ozyalvacli</au><au>Ibrahim, Dönmez</au><au>Mehmet, Yazici</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epicardial fat thickness in patients with rheumatoid arthritis</atitle><jtitle>African health sciences</jtitle><addtitle>Afr Health Sci</addtitle><date>2015-06-01</date><risdate>2015</risdate><volume>15</volume><issue>2</issue><spage>489</spage><epage>495</epage><pages>489-495</pages><issn>1680-6905</issn><eissn>1729-0503</eissn><eissn>1680-6905</eissn><abstract>Background: Epidemiologic data indicates that rheumatoid arthritis is
an independent risk factor for cardiovascular disease. Epicardial
adipose tissue is a novel cardio-metabolic risk factor. Our aim was to
evaluate epicardial fat thickness (EFT) using echocardiography in
patients with rheumatoid arthritis compared to healthy control
subjects. Secondly, we investigated relationship between epicardial fat
thickness and clinical and echocardiographic parameters in patients
with rheumatoid arthritis. Method: The study population included 76
consecutive patients with rheumatoid arthritis (64 female; mean age, 53
±11 years, median disease duration, 7.8 years) and 50 healthy
subjects as controls (39 female; mean age, 52 ± 6 years). All
patients underwent echocardiography to assess left ventricular
diastolic dysfunction, left ventricular hypertrophy and EFT. All values
were compared between groups. Results: EFT was higher in rheumatoid
arthritis patients than in healthy controls (0.66±0.20 vs.
0.54±0.18; p= 0.003). Thickness of Intra Ventricular Septum (IVS)
(1.1±0.06 and 9.8±0.08; p=0.001) and posterior wall (PW)
(0.98±0.05 and 0.93±0.08; p=0.015) was higher in patients
with rheumatoid arthritis compared to healthy controls. Early diastolic
myocardiac peak velocity or late diastolic mitral peak velocity (E/A)
ratio was lower in rheumatoid arthritis patients compared to healthy
patients (1.1 ±0.8 and 1.24±0.1 p=0.001) as well as,
E/e' was higher in Rheumatoid arthritis (RA) patients than
healthy patients. (E/e':8.7±1.6 and 8.0±1.4 p=0.020).
In patients with rheumatoid arthritis, EFT was positively correlated
with hypertension and duration of disease and E/e' (r: 0.10, p:
0.010, r: 0.306, p: 0.004 and r: 0.465 p: 0.007 respectively) and EFT
was negatively correlated with E/A (r: -.262 p:0.022 ) Conclusion: To
our knowledge, this is the first report about epicardial adipose tissue
in rheumatoid arthritis patients. Epicardial fat thickness as an
indicator of cardiovascular involvement was higher in rheumatoid
arthritis patients.</abstract><cop>Uganda</cop><pub>Makerere University Medical School</pub><pmid>26124795</pmid><doi>10.4314/ahs.v15i2.23</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | African health sciences, 2015-06, Vol.15 (2), p.489-495 |
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| language | eng |
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| source | MEDLINE; African Journals Online (Open Access); Bioline International; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Adipose Tissue - diagnostic imaging Adipose Tissue - pathology Aged Arthritis, Rheumatoid - diagnostic imaging Arthritis, Rheumatoid - pathology cardiac involvement Case-Control Studies Diastole - physiology Echocardiography, Doppler epicardial fat thickness Female Heart - physiopathology Humans Hypertension - physiopathology Intra-Abdominal Fat - pathology Male Middle Aged Pericardium - diagnostic imaging Pericardium - pathology Rheumatoid arthritis Risk Factors Ventricular Dysfunction, Left - diagnostic imaging |
| title | Epicardial fat thickness in patients with rheumatoid arthritis |
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