Effect of Astragalus complanatus flavonoid on anti-liver fibrosis in rats
AIM： To observe the anti-liver fibrosis effect of Astragalus complanatus fiavonoids （ACF） in rats. METHODS： The liver fibrosis model in rats was established by injecting interperitoneally 0.2 mL/100 g 0.5% dimethylnitrosamine, thrice a week. Meanwhile, the rats were administered ACF （30, 60, 120 mg/...
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| Veröffentlicht in: | World journal of gastroenterology : WJG 2005-10, Vol.11 (37), p.5782-5786 |
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| description | AIM： To observe the anti-liver fibrosis effect of Astragalus complanatus fiavonoids （ACF） in rats. METHODS： The liver fibrosis model in rats was established by injecting interperitoneally 0.2 mL/100 g 0.5% dimethylnitrosamine, thrice a week. Meanwhile, the rats were administered ACF （30, 60, 120 mg/kg） or colchicine （0.1 mg/kg） once a day for 1 mo. Serum N-propeptide of type Ⅰ procollagen （PINP） and type Ⅲ procollagen （PⅢNP） was measured using ELISA. Malondialdehyde （MDA） and superoxide dismutase （SOD） in hepatic tissue were evaluated. Matrix metal protease-1 （MMP-1） mRNA expression was assayed by RT-PCR and the protein expression of tissue inhibitor of metal protease-1 （TIMP-1） was analyzed by immunohistochemistry. RESULTS： In the ACF groups, SOD activity increased and MDA content decreased in comparison to the liver fibrosis model group. The serum PINP and PⅢNP contents in ACF-2 and -3 group decreased compared to those in model group. In ACF-2 and -3 group, the expression of MMP-1 mRNA increased significantly and the protein expression of TIMP-1 decreased compared to that in model group. CONCLUSION： The antifibrotic mechanisms of ACF are associated with its influence on lipid peroxidation and collagen synthesis and degradation. |
| doi_str_mv | 10.3748/wjg.v11.i37.5782 |
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| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4479676</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><cqvip_id>20626319</cqvip_id><sourcerecordid>68766932</sourcerecordid><originalsourceid>FETCH-LOGICAL-c309t-c91938aa497a41235726096c3d8e79c37cd2638fb10a1b9c6420807683c174cf3</originalsourceid><addsrcrecordid>eNpVkElPwzAQhS0EoqVw54QiDtxSvCReLkhVVRapEhc4W45jpy6p3cZpEf8eV61YTjPSvHkz7wPgGsExYQW__1w24x1CY0fYuGQcn4AhxkjkmBfwFAwRhCwXBLMBuIhxCSEmpMTnYIAoZpDwcgheZtYa3WfBZpPYd6pR7TZmOqzWrfKqT71t1S744Oos-Ez53uWt25kus67qQnQxcz7rVB8vwZlVbTRXxzoC74-zt-lzPn99eplO5rkmUPS5FkgQrlQhmCoQJiXDFAqqSc0NE5owXWNKuK0QVKgSmhYYcsgoJxqxQlsyAg8H3_W2WplaG5_ebuW6cyvVfcmgnPw_8W4hm7CTRcEEZTQZ3B0NurDZmtjLlYvatCmwCdsoKWeUJmpJCA9CnYLGztifIwjKPX-Z-MvEXyb-cs8_rdz8fe534Qg8CW6Pnovgm43zjayU_rCuNRJDmqInPN_MRI5r</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68766932</pqid></control><display><type>article</type><title>Effect of Astragalus complanatus flavonoid on anti-liver fibrosis in rats</title><source>MEDLINE</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Liu, Chun-Yu ; Gu, Zhen-Lun ; Zhou, Wen-Xuan ; Guo, Ci-Yi</creator><creatorcontrib>Liu, Chun-Yu ; Gu, Zhen-Lun ; Zhou, Wen-Xuan ; Guo, Ci-Yi</creatorcontrib><description>AIM： To observe the anti-liver fibrosis effect of Astragalus complanatus fiavonoids （ACF） in rats. METHODS： The liver fibrosis model in rats was established by injecting interperitoneally 0.2 mL/100 g 0.5% dimethylnitrosamine, thrice a week. Meanwhile, the rats were administered ACF （30, 60, 120 mg/kg） or colchicine （0.1 mg/kg） once a day for 1 mo. Serum N-propeptide of type Ⅰ procollagen （PINP） and type Ⅲ procollagen （PⅢNP） was measured using ELISA. Malondialdehyde （MDA） and superoxide dismutase （SOD） in hepatic tissue were evaluated. Matrix metal protease-1 （MMP-1） mRNA expression was assayed by RT-PCR and the protein expression of tissue inhibitor of metal protease-1 （TIMP-1） was analyzed by immunohistochemistry. RESULTS： In the ACF groups, SOD activity increased and MDA content decreased in comparison to the liver fibrosis model group. The serum PINP and PⅢNP contents in ACF-2 and -3 group decreased compared to those in model group. In ACF-2 and -3 group, the expression of MMP-1 mRNA increased significantly and the protein expression of TIMP-1 decreased compared to that in model group. CONCLUSION： The antifibrotic mechanisms of ACF are associated with its influence on lipid peroxidation and collagen synthesis and degradation.</description><identifier>ISSN: 1007-9327</identifier><identifier>EISSN: 2219-2840</identifier><identifier>DOI: 10.3748/wjg.v11.i37.5782</identifier><identifier>PMID: 16270385</identifier><language>eng</language><publisher>United States: Baishideng Publishing Group Inc</publisher><subject>Animals ; Astragalus Plant - chemistry ; Basic Research ; Collagen Type I - blood ; Collagen Type I - genetics ; Collagen Type III - blood ; Collagen Type III - genetics ; Fibrosis - drug therapy ; Fibrosis - metabolism ; Fibrosis - pathology ; Flavonoids - chemistry ; Flavonoids - therapeutic use ; Liver - metabolism ; Liver - pathology ; Liver Cirrhosis, Experimental - drug therapy ; Liver Cirrhosis, Experimental - pathology ; Male ; Malondialdehyde - metabolism ; Matrix Metalloproteinase 1 - genetics ; Matrix Metalloproteinase 1 - metabolism ; Medicine, Chinese Traditional ; Phytotherapy ; Plant Preparations - chemistry ; Plant Preparations - therapeutic use ; Procollagen - blood ; Procollagen - genetics ; Rats ; Rats, Wistar ; Superoxide Dismutase - metabolism ; Tissue Inhibitor of Metalloproteinase-1 - metabolism ; 动物实验 ; 紫云英类黄酮 ; 肝纤维化 ; 药物治疗</subject><ispartof>World journal of gastroenterology : WJG, 2005-10, Vol.11 (37), p.5782-5786</ispartof><rights>The Author(s) 2005. Published by Baishideng Publishing Group Inc. All rights reserved. 2005</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c309t-c91938aa497a41235726096c3d8e79c37cd2638fb10a1b9c6420807683c174cf3</citedby><cites>FETCH-LOGICAL-c309t-c91938aa497a41235726096c3d8e79c37cd2638fb10a1b9c6420807683c174cf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/84123X/84123X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479676/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479676/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16270385$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Chun-Yu</creatorcontrib><creatorcontrib>Gu, Zhen-Lun</creatorcontrib><creatorcontrib>Zhou, Wen-Xuan</creatorcontrib><creatorcontrib>Guo, Ci-Yi</creatorcontrib><title>Effect of Astragalus complanatus flavonoid on anti-liver fibrosis in rats</title><title>World journal of gastroenterology : WJG</title><addtitle>World Journal of Gastroenterology</addtitle><description>AIM： To observe the anti-liver fibrosis effect of Astragalus complanatus fiavonoids （ACF） in rats. METHODS： The liver fibrosis model in rats was established by injecting interperitoneally 0.2 mL/100 g 0.5% dimethylnitrosamine, thrice a week. Meanwhile, the rats were administered ACF （30, 60, 120 mg/kg） or colchicine （0.1 mg/kg） once a day for 1 mo. Serum N-propeptide of type Ⅰ procollagen （PINP） and type Ⅲ procollagen （PⅢNP） was measured using ELISA. Malondialdehyde （MDA） and superoxide dismutase （SOD） in hepatic tissue were evaluated. Matrix metal protease-1 （MMP-1） mRNA expression was assayed by RT-PCR and the protein expression of tissue inhibitor of metal protease-1 （TIMP-1） was analyzed by immunohistochemistry. RESULTS： In the ACF groups, SOD activity increased and MDA content decreased in comparison to the liver fibrosis model group. The serum PINP and PⅢNP contents in ACF-2 and -3 group decreased compared to those in model group. In ACF-2 and -3 group, the expression of MMP-1 mRNA increased significantly and the protein expression of TIMP-1 decreased compared to that in model group. CONCLUSION： The antifibrotic mechanisms of ACF are associated with its influence on lipid peroxidation and collagen synthesis and degradation.</description><subject>Animals</subject><subject>Astragalus Plant - chemistry</subject><subject>Basic Research</subject><subject>Collagen Type I - blood</subject><subject>Collagen Type I - genetics</subject><subject>Collagen Type III - blood</subject><subject>Collagen Type III - genetics</subject><subject>Fibrosis - drug therapy</subject><subject>Fibrosis - metabolism</subject><subject>Fibrosis - pathology</subject><subject>Flavonoids - chemistry</subject><subject>Flavonoids - therapeutic use</subject><subject>Liver - metabolism</subject><subject>Liver - pathology</subject><subject>Liver Cirrhosis, Experimental - drug therapy</subject><subject>Liver Cirrhosis, Experimental - pathology</subject><subject>Male</subject><subject>Malondialdehyde - metabolism</subject><subject>Matrix Metalloproteinase 1 - genetics</subject><subject>Matrix Metalloproteinase 1 - metabolism</subject><subject>Medicine, Chinese Traditional</subject><subject>Phytotherapy</subject><subject>Plant Preparations - chemistry</subject><subject>Plant Preparations - therapeutic use</subject><subject>Procollagen - blood</subject><subject>Procollagen - genetics</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Superoxide Dismutase - metabolism</subject><subject>Tissue Inhibitor of Metalloproteinase-1 - metabolism</subject><subject>动物实验</subject><subject>紫云英类黄酮</subject><subject>肝纤维化</subject><subject>药物治疗</subject><issn>1007-9327</issn><issn>2219-2840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkElPwzAQhS0EoqVw54QiDtxSvCReLkhVVRapEhc4W45jpy6p3cZpEf8eV61YTjPSvHkz7wPgGsExYQW__1w24x1CY0fYuGQcn4AhxkjkmBfwFAwRhCwXBLMBuIhxCSEmpMTnYIAoZpDwcgheZtYa3WfBZpPYd6pR7TZmOqzWrfKqT71t1S744Oos-Ez53uWt25kus67qQnQxcz7rVB8vwZlVbTRXxzoC74-zt-lzPn99eplO5rkmUPS5FkgQrlQhmCoQJiXDFAqqSc0NE5owXWNKuK0QVKgSmhYYcsgoJxqxQlsyAg8H3_W2WplaG5_ebuW6cyvVfcmgnPw_8W4hm7CTRcEEZTQZ3B0NurDZmtjLlYvatCmwCdsoKWeUJmpJCA9CnYLGztifIwjKPX-Z-MvEXyb-cs8_rdz8fe534Qg8CW6Pnovgm43zjayU_rCuNRJDmqInPN_MRI5r</recordid><startdate>20051007</startdate><enddate>20051007</enddate><creator>Liu, Chun-Yu</creator><creator>Gu, Zhen-Lun</creator><creator>Zhou, Wen-Xuan</creator><creator>Guo, Ci-Yi</creator><general>Baishideng Publishing Group Inc</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20051007</creationdate><title>Effect of Astragalus complanatus flavonoid on anti-liver fibrosis in rats</title><author>Liu, Chun-Yu ; Gu, Zhen-Lun ; Zhou, Wen-Xuan ; Guo, Ci-Yi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c309t-c91938aa497a41235726096c3d8e79c37cd2638fb10a1b9c6420807683c174cf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Astragalus Plant - chemistry</topic><topic>Basic Research</topic><topic>Collagen Type I - blood</topic><topic>Collagen Type I - genetics</topic><topic>Collagen Type III - blood</topic><topic>Collagen Type III - genetics</topic><topic>Fibrosis - drug therapy</topic><topic>Fibrosis - metabolism</topic><topic>Fibrosis - pathology</topic><topic>Flavonoids - chemistry</topic><topic>Flavonoids - therapeutic use</topic><topic>Liver - metabolism</topic><topic>Liver - pathology</topic><topic>Liver Cirrhosis, Experimental - drug therapy</topic><topic>Liver Cirrhosis, Experimental - pathology</topic><topic>Male</topic><topic>Malondialdehyde - metabolism</topic><topic>Matrix Metalloproteinase 1 - genetics</topic><topic>Matrix Metalloproteinase 1 - metabolism</topic><topic>Medicine, Chinese Traditional</topic><topic>Phytotherapy</topic><topic>Plant Preparations - chemistry</topic><topic>Plant Preparations - therapeutic use</topic><topic>Procollagen - blood</topic><topic>Procollagen - genetics</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Superoxide Dismutase - metabolism</topic><topic>Tissue Inhibitor of Metalloproteinase-1 - metabolism</topic><topic>动物实验</topic><topic>紫云英类黄酮</topic><topic>肝纤维化</topic><topic>药物治疗</topic><toplevel>online_resources</toplevel><creatorcontrib>Liu, Chun-Yu</creatorcontrib><creatorcontrib>Gu, Zhen-Lun</creatorcontrib><creatorcontrib>Zhou, Wen-Xuan</creatorcontrib><creatorcontrib>Guo, Ci-Yi</creatorcontrib><collection>维普_期刊</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>维普中文期刊数据库</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>World journal of gastroenterology : WJG</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Chun-Yu</au><au>Gu, Zhen-Lun</au><au>Zhou, Wen-Xuan</au><au>Guo, Ci-Yi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Astragalus complanatus flavonoid on anti-liver fibrosis in rats</atitle><jtitle>World journal of gastroenterology : WJG</jtitle><addtitle>World Journal of Gastroenterology</addtitle><date>2005-10-07</date><risdate>2005</risdate><volume>11</volume><issue>37</issue><spage>5782</spage><epage>5786</epage><pages>5782-5786</pages><issn>1007-9327</issn><eissn>2219-2840</eissn><abstract>AIM： To observe the anti-liver fibrosis effect of Astragalus complanatus fiavonoids （ACF） in rats. METHODS： The liver fibrosis model in rats was established by injecting interperitoneally 0.2 mL/100 g 0.5% dimethylnitrosamine, thrice a week. Meanwhile, the rats were administered ACF （30, 60, 120 mg/kg） or colchicine （0.1 mg/kg） once a day for 1 mo. Serum N-propeptide of type Ⅰ procollagen （PINP） and type Ⅲ procollagen （PⅢNP） was measured using ELISA. Malondialdehyde （MDA） and superoxide dismutase （SOD） in hepatic tissue were evaluated. Matrix metal protease-1 （MMP-1） mRNA expression was assayed by RT-PCR and the protein expression of tissue inhibitor of metal protease-1 （TIMP-1） was analyzed by immunohistochemistry. RESULTS： In the ACF groups, SOD activity increased and MDA content decreased in comparison to the liver fibrosis model group. The serum PINP and PⅢNP contents in ACF-2 and -3 group decreased compared to those in model group. In ACF-2 and -3 group, the expression of MMP-1 mRNA increased significantly and the protein expression of TIMP-1 decreased compared to that in model group. CONCLUSION： The antifibrotic mechanisms of ACF are associated with its influence on lipid peroxidation and collagen synthesis and degradation.</abstract><cop>United States</cop><pub>Baishideng Publishing Group Inc</pub><pmid>16270385</pmid><doi>10.3748/wjg.v11.i37.5782</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Astragalus Plant - chemistry Basic Research Collagen Type I - blood Collagen Type I - genetics Collagen Type III - blood Collagen Type III - genetics Fibrosis - drug therapy Fibrosis - metabolism Fibrosis - pathology Flavonoids - chemistry Flavonoids - therapeutic use Liver - metabolism Liver - pathology Liver Cirrhosis, Experimental - drug therapy Liver Cirrhosis, Experimental - pathology Male Malondialdehyde - metabolism Matrix Metalloproteinase 1 - genetics Matrix Metalloproteinase 1 - metabolism Medicine, Chinese Traditional Phytotherapy Plant Preparations - chemistry Plant Preparations - therapeutic use Procollagen - blood Procollagen - genetics Rats Rats, Wistar Superoxide Dismutase - metabolism Tissue Inhibitor of Metalloproteinase-1 - metabolism 动物实验 紫云英类黄酮 肝纤维化 药物治疗 |
| title | Effect of Astragalus complanatus flavonoid on anti-liver fibrosis in rats |
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