Insulin resistance is associated with epigenetic and genetic regulation of mitochondrial DNA in obese humans

Mitochondrial alterations have been observed in subjects with metabolic disorders such as obesity and diabetes. Studies on animal models and cell cultures suggest aberrant glucose and lipid levels, and impaired insulin signaling might lead to mitochondrial changes. However, the molecular mechanism u...

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Veröffentlicht in:	Clinical epigenetics 2015-06, Vol.7 (1), p.60-60, Article 60
Hauptverfasser:	Zheng, Louise D, Linarelli, Leah E, Liu, Longhua, Wall, Sarah S, Greenawald, Mark H, Seidel, Richard W, Estabrooks, Paul A, Almeida, Fabio A, Cheng, Zhiyong
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Dextrose Epigenetic inheritance Genetic aspects Genetic research Genetic transcription Genomes Genomics Glucose Insulin resistance Methylation Mitochondrial DNA Obesity Physiological aspects Type 2 diabetes
Online-Zugang:	Volltext
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