The RNA-binding protein HuR is essential for the B cell antibody response

The RNA-binding protein HuR post-transcriptionally regulates mRNA splicing. Turner and colleagues demonstrate that HuR serves a critical role in thymus-independent antigen responses by regulating the fate of genes related to B cell energy use. Post-transcriptional regulation of mRNA by the RNA-bindi...

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Veröffentlicht in:	Nature immunology 2015-04, Vol.16 (4), p.415-425
Hauptverfasser:	Diaz-Muñoz, Manuel D, Bell, Sarah E, Fairfax, Kirsten, Monzon-Casanova, Elisa, Cunningham, Adam F, Gonzalez-Porta, Mar, Andrews, Simon R, Bunik, Victoria I, Zarnack, Kathi, Curk, Tomaž, Heggermont, Ward A, Heymans, Stephane, Gibson, Gary E, Kontoyiannis, Dimitris L, Ule, Jernej, Turner, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/2 13/31 45 45/91 631/1647/514/2254 631/250/1619/40 631/250/2152/2153 631/250/2502/248 64/60 96/106 Acyltransferases - genetics Acyltransferases - immunology Alternative Splicing - immunology Animals Antigens - administration & dosage Antigens - immunology B-Lymphocytes - cytology B-Lymphocytes - drug effects B-Lymphocytes - immunology Biomedicine Cell Death Cell Differentiation Cell Proliferation ELAV Proteins - genetics ELAV Proteins - immunology Erythrocytes - immunology Germinal Center - cytology Germinal Center - drug effects Germinal Center - immunology Immunity, Humoral Immunization Immunoglobulin Class Switching Immunoglobulins - biosynthesis Immunology Infectious Diseases Lipopolysaccharides - pharmacology Mice Mice, Inbred C57BL Mice, Knockout Mitochondria - genetics Mitochondria - immunology Reactive Oxygen Species - immunology Reactive Oxygen Species - metabolism RNA, Messenger - genetics RNA, Messenger - immunology Sheep
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