Intestinal intraepithelial lymphocyte activation promotes innate antiviral resistance

Unrelenting environmental challenges to the gut epithelium place particular demands on the local immune system. In this context, intestinal intraepithelial lymphocytes (IEL) compose a large, highly conserved T cell compartment, hypothesized to provide a first line of defence via cytolysis of dysregu...

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Veröffentlicht in:	Nature communications 2015-05, Vol.6 (1), p.7090, Article 7090
Hauptverfasser:	Swamy, Mahima, Abeler-Dörner, Lucie, Chettle, James, Mahlakõiv, Tanel, Goubau, Delphine, Chakravarty, Probir, Ramsay, George, Reis e Sousa, Caetano, Staeheli, Peter, Blacklaws, Barbara A., Heeney, Jonathan L., Hayday, Adrian C.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 13/21 13/51 14/19 38/61 38/77 631/250/127/1212 631/250/1619/554 631/250/347 631/326/22/1434 64/110 64/60 82/29 96/1 96/31 Animals Antiviral drugs Biology Caliciviridae Infections - immunology Cell activation Cytokines Cytokines - metabolism Cytolysis Cytotoxicity Epithelial cells Epithelial Cells - immunology Epithelium Female Gastroenteritis - immunology Gastroenteritis - virology Gene expression Genes Humanities and Social Sciences Immune system Immunity, Innate Infections Interferon Interferon-alpha - metabolism Interferon-gamma - metabolism Interferons - metabolism Intestine Intestine, Small - metabolism Lymphocyte Activation Lymphocytes Lymphocytes - immunology Lymphocytes T Macrophages - cytology Mice Mice, Inbred C57BL Mice, Knockout multidisciplinary Norovirus - immunology Science Science (multidisciplinary) T-Lymphocytes - immunology Villus Viruses
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