Loss of Faap20 Causes Hematopoietic Stem and Progenitor Cell Depletion in Mice Under Genotoxic Stress

20‐kDa FANCA‐associated protein (FAAP20) is a recently identified protein that associates with the Fanconi anemia (FA) core complex component, FANCA. FAAP20 contains a conserved ubiquitin‐binding zinc‐finger domain and plays critical roles in the FA‐BRCA pathway of DNA repair and genome maintenance....

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Veröffentlicht in:	Stem cells (Dayton, Ohio) Ohio), 2015-07, Vol.33 (7), p.2320-2330
Hauptverfasser:	Zhang, Tingting, Wilson, Andrew F., Mahmood Ali, Abdullah, Namekawa, Satoshi H., Andreassen, Paul R., Ruhikanta Meetei, Amom, Pang, Qishen
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acyl-tRNA Synthetases - genetics Amino Acyl-tRNA Synthetases - metabolism Animals Bone marrow Cell cycle Cell Differentiation DNA Damage Erythroid differentiation Fanconi anemia Fanconi Anemia - genetics Fanconi Anemia - metabolism Fanconi Anemia - mortality Hematopoietic progenitors Hematopoietic Stem Cells - metabolism Humans Mice Mice, Inbred C57BL Rodents Stem Cells Survival Analysis
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