The unpredictability of prolonged activation of stress response pathways
In response to stress, cellular compartments activate signaling pathways that mediate transcriptional programs to promote survival and reestablish homeostasis. Manipulation of the magnitude and duration of the activation of stress responses has been proposed as a strategy to prevent or repair the da...
Gespeichert in:
| Veröffentlicht in: | The Journal of cell biology 2015-06, Vol.209 (6), p.781-787 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 787 |
|---|---|
| container_issue | 6 |
| container_start_page | 781 |
| container_title | The Journal of cell biology |
| container_volume | 209 |
| creator | Lamech, Lilian T Haynes, Cole M |
| description | In response to stress, cellular compartments activate signaling pathways that mediate transcriptional programs to promote survival and reestablish homeostasis. Manipulation of the magnitude and duration of the activation of stress responses has been proposed as a strategy to prevent or repair the damage associated with aging or degenerative diseases. However, as these pathways likely evolved to respond specifically to transient perturbations, the unpredictability of prolonged activation should be considered. |
| doi_str_mv | 10.1083/jcb.201503107 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4477854</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3729945871</sourcerecordid><originalsourceid>FETCH-LOGICAL-c415t-9b5d16e33942b6eef1e25c764d000dd2480e6de91e89900278fb692e7ec330943</originalsourceid><addsrcrecordid>eNpdkc1P3DAQxa0KVLYLx16rSFx6CR1_JfEFqUJtQULqBc6W40xYr7JxsB3Q_vc4gq4ol7E0_unpzXuEfKVwQaHhP7a2vWBAJXAK9SeyolJA2VABR2QFwGipJJMn5EuMWwAQteCfyQmrKFBG5Ypc322wmMcpYOdsMq0bXNoXvi-m4Ac_PmBXGJvck0nOj8s-poAxFnlMfoxYTCZtns0-npLj3gwRz97eNbn__evu6rq8_fvn5urnbWkFlalUrexohZwrwdoKsafIpK0r0WV3XcdEA1h1qCg2SmX_ddO3lWJYo-UclOBrcvmqO83tDjuLYwpm0FNwOxP22hun__8Z3UY_-CctRF03chH4_iYQ_OOMMemdixaHwYzo56hppZZwmhzumpx_QLd-DmM-b6FYTlNBnanylbLBxxiwP5ihoJeOdO5IHzrK_Lf3Fxzof6XwF05KjTo</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1692047907</pqid></control><display><type>article</type><title>The unpredictability of prolonged activation of stress response pathways</title><source>MEDLINE</source><source>Free E-Journal (出版社公開部分のみ）</source><source>Alma/SFX Local Collection</source><creator>Lamech, Lilian T ; Haynes, Cole M</creator><creatorcontrib>Lamech, Lilian T ; Haynes, Cole M</creatorcontrib><description>In response to stress, cellular compartments activate signaling pathways that mediate transcriptional programs to promote survival and reestablish homeostasis. Manipulation of the magnitude and duration of the activation of stress responses has been proposed as a strategy to prevent or repair the damage associated with aging or degenerative diseases. However, as these pathways likely evolved to respond specifically to transient perturbations, the unpredictability of prolonged activation should be considered.</description><identifier>ISSN: 0021-9525</identifier><identifier>EISSN: 1540-8140</identifier><identifier>DOI: 10.1083/jcb.201503107</identifier><identifier>PMID: 26101215</identifier><identifier>CODEN: JCLBA3</identifier><language>eng</language><publisher>United States: Rockefeller University Press</publisher><subject>Activating Transcription Factor 1 - metabolism ; Aging - physiology ; DNA-Binding Proteins - metabolism ; Heat Shock Transcription Factors ; Heat-Shock Response - physiology ; Homeostasis ; Humans ; Predictions ; Proteostasis Deficiencies - physiopathology ; Regulatory Factor X Transcription Factors ; Reviews ; Signal Transduction ; Stress response ; Stress, Physiological - physiology ; Transcription Factors - metabolism ; Transcriptional Activation ; Unfolded Protein Response - physiology</subject><ispartof>The Journal of cell biology, 2015-06, Vol.209 (6), p.781-787</ispartof><rights>2015 Lamech and Haynes.</rights><rights>Copyright Rockefeller University Press Jun 22, 2015</rights><rights>2015 Lamech and Haynes 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-9b5d16e33942b6eef1e25c764d000dd2480e6de91e89900278fb692e7ec330943</citedby><cites>FETCH-LOGICAL-c415t-9b5d16e33942b6eef1e25c764d000dd2480e6de91e89900278fb692e7ec330943</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26101215$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lamech, Lilian T</creatorcontrib><creatorcontrib>Haynes, Cole M</creatorcontrib><title>The unpredictability of prolonged activation of stress response pathways</title><title>The Journal of cell biology</title><addtitle>J Cell Biol</addtitle><description>In response to stress, cellular compartments activate signaling pathways that mediate transcriptional programs to promote survival and reestablish homeostasis. Manipulation of the magnitude and duration of the activation of stress responses has been proposed as a strategy to prevent or repair the damage associated with aging or degenerative diseases. However, as these pathways likely evolved to respond specifically to transient perturbations, the unpredictability of prolonged activation should be considered.</description><subject>Activating Transcription Factor 1 - metabolism</subject><subject>Aging - physiology</subject><subject>DNA-Binding Proteins - metabolism</subject><subject>Heat Shock Transcription Factors</subject><subject>Heat-Shock Response - physiology</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Predictions</subject><subject>Proteostasis Deficiencies - physiopathology</subject><subject>Regulatory Factor X Transcription Factors</subject><subject>Reviews</subject><subject>Signal Transduction</subject><subject>Stress response</subject><subject>Stress, Physiological - physiology</subject><subject>Transcription Factors - metabolism</subject><subject>Transcriptional Activation</subject><subject>Unfolded Protein Response - physiology</subject><issn>0021-9525</issn><issn>1540-8140</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkc1P3DAQxa0KVLYLx16rSFx6CR1_JfEFqUJtQULqBc6W40xYr7JxsB3Q_vc4gq4ol7E0_unpzXuEfKVwQaHhP7a2vWBAJXAK9SeyolJA2VABR2QFwGipJJMn5EuMWwAQteCfyQmrKFBG5Ypc322wmMcpYOdsMq0bXNoXvi-m4Ac_PmBXGJvck0nOj8s-poAxFnlMfoxYTCZtns0-npLj3gwRz97eNbn__evu6rq8_fvn5urnbWkFlalUrexohZwrwdoKsafIpK0r0WV3XcdEA1h1qCg2SmX_ddO3lWJYo-UclOBrcvmqO83tDjuLYwpm0FNwOxP22hun__8Z3UY_-CctRF03chH4_iYQ_OOMMemdixaHwYzo56hppZZwmhzumpx_QLd-DmM-b6FYTlNBnanylbLBxxiwP5ihoJeOdO5IHzrK_Lf3Fxzof6XwF05KjTo</recordid><startdate>20150622</startdate><enddate>20150622</enddate><creator>Lamech, Lilian T</creator><creator>Haynes, Cole M</creator><general>Rockefeller University Press</general><general>The Rockefeller University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150622</creationdate><title>The unpredictability of prolonged activation of stress response pathways</title><author>Lamech, Lilian T ; Haynes, Cole M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-9b5d16e33942b6eef1e25c764d000dd2480e6de91e89900278fb692e7ec330943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Activating Transcription Factor 1 - metabolism</topic><topic>Aging - physiology</topic><topic>DNA-Binding Proteins - metabolism</topic><topic>Heat Shock Transcription Factors</topic><topic>Heat-Shock Response - physiology</topic><topic>Homeostasis</topic><topic>Humans</topic><topic>Predictions</topic><topic>Proteostasis Deficiencies - physiopathology</topic><topic>Regulatory Factor X Transcription Factors</topic><topic>Reviews</topic><topic>Signal Transduction</topic><topic>Stress response</topic><topic>Stress, Physiological - physiology</topic><topic>Transcription Factors - metabolism</topic><topic>Transcriptional Activation</topic><topic>Unfolded Protein Response - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lamech, Lilian T</creatorcontrib><creatorcontrib>Haynes, Cole M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of cell biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lamech, Lilian T</au><au>Haynes, Cole M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The unpredictability of prolonged activation of stress response pathways</atitle><jtitle>The Journal of cell biology</jtitle><addtitle>J Cell Biol</addtitle><date>2015-06-22</date><risdate>2015</risdate><volume>209</volume><issue>6</issue><spage>781</spage><epage>787</epage><pages>781-787</pages><issn>0021-9525</issn><eissn>1540-8140</eissn><coden>JCLBA3</coden><abstract>In response to stress, cellular compartments activate signaling pathways that mediate transcriptional programs to promote survival and reestablish homeostasis. Manipulation of the magnitude and duration of the activation of stress responses has been proposed as a strategy to prevent or repair the damage associated with aging or degenerative diseases. However, as these pathways likely evolved to respond specifically to transient perturbations, the unpredictability of prolonged activation should be considered.</abstract><cop>United States</cop><pub>Rockefeller University Press</pub><pmid>26101215</pmid><doi>10.1083/jcb.201503107</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-9525 |
| ispartof | The Journal of cell biology, 2015-06, Vol.209 (6), p.781-787 |
| issn | 0021-9525 1540-8140 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4477854 |
| source | MEDLINE; Free E-Journal (出版社公開部分のみ）; Alma/SFX Local Collection |
| subjects | Activating Transcription Factor 1 - metabolism Aging - physiology DNA-Binding Proteins - metabolism Heat Shock Transcription Factors Heat-Shock Response - physiology Homeostasis Humans Predictions Proteostasis Deficiencies - physiopathology Regulatory Factor X Transcription Factors Reviews Signal Transduction Stress response Stress, Physiological - physiology Transcription Factors - metabolism Transcriptional Activation Unfolded Protein Response - physiology |
| title | The unpredictability of prolonged activation of stress response pathways |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-20T15%3A00%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20unpredictability%20of%20prolonged%20activation%20of%20stress%20response%20pathways&rft.jtitle=The%20Journal%20of%20cell%20biology&rft.au=Lamech,%20Lilian%20T&rft.date=2015-06-22&rft.volume=209&rft.issue=6&rft.spage=781&rft.epage=787&rft.pages=781-787&rft.issn=0021-9525&rft.eissn=1540-8140&rft.coden=JCLBA3&rft_id=info:doi/10.1083/jcb.201503107&rft_dat=%3Cproquest_pubme%3E3729945871%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1692047907&rft_id=info:pmid/26101215&rfr_iscdi=true |