Development of a calcium-sensing receptor molecular imaging agent

Background Calcium-sensing receptor (CaSR) is expressed by parathyroid cells and thyroid C-cells (from which medullary thyroid carcinoma [MTC] is derived). A molecular imaging agent localizing to the CaSR could improve the detection of parathyroids and MTC preoperatively or intraoperatively. We synt...

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Veröffentlicht in:	Surgery 2013-12, Vol.154 (6), p.1378-1384
Hauptverfasser:	Yusof, Adlina Mohd, PhD, Kothandaraman, Shankaran, PhD, Zhang, Xiaoli, PhD, Saji, Motoyasu, MD, PhD, Ringel, Matthew D., MD, Tweedle, Michael F., PhD, Phay, John E., MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Benzamides - chemical synthesis Benzamides - chemistry Carcinoma, Medullary - metabolism Carcinoma, Medullary - pathology Carcinoma, Medullary - surgery Carcinoma, Neuroendocrine Cyclohexylamines - chemical synthesis Cyclohexylamines - chemistry Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism HEK293 Cells Humans MAP Kinase Signaling System Mass Spectrometry Molecular Imaging - methods Parathyroid Glands - metabolism Parathyroid Glands - pathology Receptors, Calcium-Sensing - antagonists & inhibitors Receptors, Calcium-Sensing - genetics Receptors, Calcium-Sensing - metabolism Recombinant Proteins - genetics Recombinant Proteins - metabolism Surgery Thyroid Neoplasms - metabolism Thyroid Neoplasms - pathology Thyroid Neoplasms - surgery
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