Risk factors for small bowel angioectasia: The impact of visceral fat accumulation
To investigate visceral fat accumulation in association with the risk of small bowel angioectasia. We retrospectively investigated 198 consecutive patients who underwent both capsule endoscopy and CT for investigation of obscure gastrointestinal bleeding (OGIB) from January 2009 to September 2013. T...
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| Veröffentlicht in: | World journal of gastroenterology : WJG 2015-06, Vol.21 (23), p.7242-7247 |
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| container_title | World journal of gastroenterology : WJG |
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| creator | Yamada, Atsuo Niikura, Ryota Kobayashi, Yuka Suzuki, Hirobumi Yoshida, Shuntaro Watabe, Hirotsugu Yamaji, Yutaka Hirata, Yoshihiro Koike, Kazuhiko |
| description | To investigate visceral fat accumulation in association with the risk of small bowel angioectasia.
We retrospectively investigated 198 consecutive patients who underwent both capsule endoscopy and CT for investigation of obscure gastrointestinal bleeding (OGIB) from January 2009 to September 2013. The visceral fat area (VFA) and subcutaneous fat area were measured by CT, and information on comorbidities, body mass index, and medications was obtained from their medical records. Logistic regression analysis was used to evaluate associations.
Capsule endoscopy revealed small bowel angioectasia in 18/198 (9.1%) patients with OGIB. Compared to patients without small bowel angioectasia, those with small bowel angioectasia had a significantly higher VFA (96 ± 76.0 cm(2) vs 63.4 ± 51.5 cm(2), P = 0.016) and a higher prevalence of liver cirrhosis (61% vs 22%, P < 0.001). The proportion of patients with chronic renal failure was higher in patients with small bowel angioectasia (22% vs 9%, P = 0.11). There were no significant differences in subcutaneous fat area or waist circumference. The prevalence of small bowel angioectasia progressively increased according to the VFA. Multivariate analysis showed that the VFA [odd ratio (OR) for each 10-cm(2) increment = 1.1; [95% confidence interval (CI): 1.02-1.19; P = 0.021] and liver cirrhosis (OR = 6.1, 95%CI: 2.2-18.5; P < 0.001) were significant risk factors for small bowel angioectasia.
VFA is positively associated with the prevalence of small bowel angioectasia, for which VFA and liver cirrhosis are independent risk factors in patients with OGIB. |
| doi_str_mv | 10.3748/wjg.v21.i23.7242 |
| format | Article |
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We retrospectively investigated 198 consecutive patients who underwent both capsule endoscopy and CT for investigation of obscure gastrointestinal bleeding (OGIB) from January 2009 to September 2013. The visceral fat area (VFA) and subcutaneous fat area were measured by CT, and information on comorbidities, body mass index, and medications was obtained from their medical records. Logistic regression analysis was used to evaluate associations.
Capsule endoscopy revealed small bowel angioectasia in 18/198 (9.1%) patients with OGIB. Compared to patients without small bowel angioectasia, those with small bowel angioectasia had a significantly higher VFA (96 ± 76.0 cm(2) vs 63.4 ± 51.5 cm(2), P = 0.016) and a higher prevalence of liver cirrhosis (61% vs 22%, P < 0.001). The proportion of patients with chronic renal failure was higher in patients with small bowel angioectasia (22% vs 9%, P = 0.11). There were no significant differences in subcutaneous fat area or waist circumference. The prevalence of small bowel angioectasia progressively increased according to the VFA. Multivariate analysis showed that the VFA [odd ratio (OR) for each 10-cm(2) increment = 1.1; [95% confidence interval (CI): 1.02-1.19; P = 0.021] and liver cirrhosis (OR = 6.1, 95%CI: 2.2-18.5; P < 0.001) were significant risk factors for small bowel angioectasia.
VFA is positively associated with the prevalence of small bowel angioectasia, for which VFA and liver cirrhosis are independent risk factors in patients with OGIB.</description><identifier>ISSN: 1007-9327</identifier><identifier>EISSN: 2219-2840</identifier><identifier>DOI: 10.3748/wjg.v21.i23.7242</identifier><identifier>PMID: 26109811</identifier><language>eng</language><publisher>United States: Baishideng Publishing Group Inc</publisher><subject>Adiposity ; Aged ; Capsule Endoscopy ; Comorbidity ; Dilatation, Pathologic ; Female ; Gastrointestinal Hemorrhage - diagnosis ; Gastrointestinal Hemorrhage - epidemiology ; Humans ; Intestinal Mucosa - blood supply ; Intestine, Small - blood supply ; Intra-Abdominal Fat - diagnostic imaging ; Intra-Abdominal Fat - physiopathology ; Japan - epidemiology ; Liver Cirrhosis - epidemiology ; Logistic Models ; Male ; Middle Aged ; Multivariate Analysis ; Obesity - diagnosis ; Obesity - epidemiology ; Obesity - physiopathology ; Odds Ratio ; Prevalence ; Retrospective Studies ; Retrospective Study ; Risk Factors ; Tomography, X-Ray Computed</subject><ispartof>World journal of gastroenterology : WJG, 2015-06, Vol.21 (23), p.7242-7247</ispartof><rights>The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. 2015</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c462t-54b5c3d2680a2f2c0add4ea3a5da7348cce9eb05bdf7dce364d14f0681bd276e3</citedby><cites>FETCH-LOGICAL-c462t-54b5c3d2680a2f2c0add4ea3a5da7348cce9eb05bdf7dce364d14f0681bd276e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476886/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476886/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26109811$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yamada, Atsuo</creatorcontrib><creatorcontrib>Niikura, Ryota</creatorcontrib><creatorcontrib>Kobayashi, Yuka</creatorcontrib><creatorcontrib>Suzuki, Hirobumi</creatorcontrib><creatorcontrib>Yoshida, Shuntaro</creatorcontrib><creatorcontrib>Watabe, Hirotsugu</creatorcontrib><creatorcontrib>Yamaji, Yutaka</creatorcontrib><creatorcontrib>Hirata, Yoshihiro</creatorcontrib><creatorcontrib>Koike, Kazuhiko</creatorcontrib><title>Risk factors for small bowel angioectasia: The impact of visceral fat accumulation</title><title>World journal of gastroenterology : WJG</title><addtitle>World J Gastroenterol</addtitle><description>To investigate visceral fat accumulation in association with the risk of small bowel angioectasia.
We retrospectively investigated 198 consecutive patients who underwent both capsule endoscopy and CT for investigation of obscure gastrointestinal bleeding (OGIB) from January 2009 to September 2013. The visceral fat area (VFA) and subcutaneous fat area were measured by CT, and information on comorbidities, body mass index, and medications was obtained from their medical records. Logistic regression analysis was used to evaluate associations.
Capsule endoscopy revealed small bowel angioectasia in 18/198 (9.1%) patients with OGIB. Compared to patients without small bowel angioectasia, those with small bowel angioectasia had a significantly higher VFA (96 ± 76.0 cm(2) vs 63.4 ± 51.5 cm(2), P = 0.016) and a higher prevalence of liver cirrhosis (61% vs 22%, P < 0.001). The proportion of patients with chronic renal failure was higher in patients with small bowel angioectasia (22% vs 9%, P = 0.11). There were no significant differences in subcutaneous fat area or waist circumference. The prevalence of small bowel angioectasia progressively increased according to the VFA. Multivariate analysis showed that the VFA [odd ratio (OR) for each 10-cm(2) increment = 1.1; [95% confidence interval (CI): 1.02-1.19; P = 0.021] and liver cirrhosis (OR = 6.1, 95%CI: 2.2-18.5; P < 0.001) were significant risk factors for small bowel angioectasia.
VFA is positively associated with the prevalence of small bowel angioectasia, for which VFA and liver cirrhosis are independent risk factors in patients with OGIB.</description><subject>Adiposity</subject><subject>Aged</subject><subject>Capsule Endoscopy</subject><subject>Comorbidity</subject><subject>Dilatation, Pathologic</subject><subject>Female</subject><subject>Gastrointestinal Hemorrhage - diagnosis</subject><subject>Gastrointestinal Hemorrhage - epidemiology</subject><subject>Humans</subject><subject>Intestinal Mucosa - blood supply</subject><subject>Intestine, Small - blood supply</subject><subject>Intra-Abdominal Fat - diagnostic imaging</subject><subject>Intra-Abdominal Fat - physiopathology</subject><subject>Japan - epidemiology</subject><subject>Liver Cirrhosis - epidemiology</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Obesity - diagnosis</subject><subject>Obesity - epidemiology</subject><subject>Obesity - physiopathology</subject><subject>Odds Ratio</subject><subject>Prevalence</subject><subject>Retrospective Studies</subject><subject>Retrospective Study</subject><subject>Risk Factors</subject><subject>Tomography, X-Ray Computed</subject><issn>1007-9327</issn><issn>2219-2840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkUtLxDAUhYMoOj72riRLNx2TmzRpXQgivkAQRNfhNk3HaNuMTTvivzeDD3R1F_eccx8fIYeczYWWxcn7y2K-Aj73IOYaJGyQGQAvMygk2yQzzpjOSgF6h-zG-MIYCJHDNtkBxVlZcD4jDw8-vtIG7RiGSJsw0Nhh29IqvLuWYr_wwdkRo8dT-vjsqO-WSUtDQ1c-Wjdgm8wjRWunbmpx9KHfJ1sNttEdfNc98nR1-Xhxk93dX99enN9lVioYs1xWuRU1qIIhNGAZ1rV0KDCvUQtZWOtKV7G8qhtdWyeUrLlsmCp4VYNWTuyRs6_c5VR1Lkn6Ma1jloPvcPgwAb353-n9s1mElZFSq6JQKeD4O2AIb5OLo-nWN7Ut9i5M0XBV8ryUkOskZV9SO4QYB9f8juHMrFGYhMIkFCahMGsUyXL0d71fw8_vxSfEp4ij</recordid><startdate>20150621</startdate><enddate>20150621</enddate><creator>Yamada, Atsuo</creator><creator>Niikura, Ryota</creator><creator>Kobayashi, Yuka</creator><creator>Suzuki, Hirobumi</creator><creator>Yoshida, Shuntaro</creator><creator>Watabe, Hirotsugu</creator><creator>Yamaji, Yutaka</creator><creator>Hirata, Yoshihiro</creator><creator>Koike, Kazuhiko</creator><general>Baishideng Publishing Group Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150621</creationdate><title>Risk factors for small bowel angioectasia: The impact of visceral fat accumulation</title><author>Yamada, Atsuo ; Niikura, Ryota ; Kobayashi, Yuka ; Suzuki, Hirobumi ; Yoshida, Shuntaro ; Watabe, Hirotsugu ; Yamaji, Yutaka ; Hirata, Yoshihiro ; Koike, Kazuhiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c462t-54b5c3d2680a2f2c0add4ea3a5da7348cce9eb05bdf7dce364d14f0681bd276e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adiposity</topic><topic>Aged</topic><topic>Capsule Endoscopy</topic><topic>Comorbidity</topic><topic>Dilatation, Pathologic</topic><topic>Female</topic><topic>Gastrointestinal Hemorrhage - diagnosis</topic><topic>Gastrointestinal Hemorrhage - epidemiology</topic><topic>Humans</topic><topic>Intestinal Mucosa - blood supply</topic><topic>Intestine, Small - blood supply</topic><topic>Intra-Abdominal Fat - diagnostic imaging</topic><topic>Intra-Abdominal Fat - physiopathology</topic><topic>Japan - epidemiology</topic><topic>Liver Cirrhosis - epidemiology</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Obesity - diagnosis</topic><topic>Obesity - epidemiology</topic><topic>Obesity - physiopathology</topic><topic>Odds Ratio</topic><topic>Prevalence</topic><topic>Retrospective Studies</topic><topic>Retrospective Study</topic><topic>Risk Factors</topic><topic>Tomography, X-Ray Computed</topic><toplevel>online_resources</toplevel><creatorcontrib>Yamada, Atsuo</creatorcontrib><creatorcontrib>Niikura, Ryota</creatorcontrib><creatorcontrib>Kobayashi, Yuka</creatorcontrib><creatorcontrib>Suzuki, Hirobumi</creatorcontrib><creatorcontrib>Yoshida, Shuntaro</creatorcontrib><creatorcontrib>Watabe, Hirotsugu</creatorcontrib><creatorcontrib>Yamaji, Yutaka</creatorcontrib><creatorcontrib>Hirata, Yoshihiro</creatorcontrib><creatorcontrib>Koike, Kazuhiko</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>World journal of gastroenterology : WJG</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yamada, Atsuo</au><au>Niikura, Ryota</au><au>Kobayashi, Yuka</au><au>Suzuki, Hirobumi</au><au>Yoshida, Shuntaro</au><au>Watabe, Hirotsugu</au><au>Yamaji, Yutaka</au><au>Hirata, Yoshihiro</au><au>Koike, Kazuhiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk factors for small bowel angioectasia: The impact of visceral fat accumulation</atitle><jtitle>World journal of gastroenterology : WJG</jtitle><addtitle>World J Gastroenterol</addtitle><date>2015-06-21</date><risdate>2015</risdate><volume>21</volume><issue>23</issue><spage>7242</spage><epage>7247</epage><pages>7242-7247</pages><issn>1007-9327</issn><eissn>2219-2840</eissn><abstract>To investigate visceral fat accumulation in association with the risk of small bowel angioectasia.
We retrospectively investigated 198 consecutive patients who underwent both capsule endoscopy and CT for investigation of obscure gastrointestinal bleeding (OGIB) from January 2009 to September 2013. The visceral fat area (VFA) and subcutaneous fat area were measured by CT, and information on comorbidities, body mass index, and medications was obtained from their medical records. Logistic regression analysis was used to evaluate associations.
Capsule endoscopy revealed small bowel angioectasia in 18/198 (9.1%) patients with OGIB. Compared to patients without small bowel angioectasia, those with small bowel angioectasia had a significantly higher VFA (96 ± 76.0 cm(2) vs 63.4 ± 51.5 cm(2), P = 0.016) and a higher prevalence of liver cirrhosis (61% vs 22%, P < 0.001). The proportion of patients with chronic renal failure was higher in patients with small bowel angioectasia (22% vs 9%, P = 0.11). There were no significant differences in subcutaneous fat area or waist circumference. The prevalence of small bowel angioectasia progressively increased according to the VFA. Multivariate analysis showed that the VFA [odd ratio (OR) for each 10-cm(2) increment = 1.1; [95% confidence interval (CI): 1.02-1.19; P = 0.021] and liver cirrhosis (OR = 6.1, 95%CI: 2.2-18.5; P < 0.001) were significant risk factors for small bowel angioectasia.
VFA is positively associated with the prevalence of small bowel angioectasia, for which VFA and liver cirrhosis are independent risk factors in patients with OGIB.</abstract><cop>United States</cop><pub>Baishideng Publishing Group Inc</pub><pmid>26109811</pmid><doi>10.3748/wjg.v21.i23.7242</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Baishideng "World Journal of" online journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adiposity Aged Capsule Endoscopy Comorbidity Dilatation, Pathologic Female Gastrointestinal Hemorrhage - diagnosis Gastrointestinal Hemorrhage - epidemiology Humans Intestinal Mucosa - blood supply Intestine, Small - blood supply Intra-Abdominal Fat - diagnostic imaging Intra-Abdominal Fat - physiopathology Japan - epidemiology Liver Cirrhosis - epidemiology Logistic Models Male Middle Aged Multivariate Analysis Obesity - diagnosis Obesity - epidemiology Obesity - physiopathology Odds Ratio Prevalence Retrospective Studies Retrospective Study Risk Factors Tomography, X-Ray Computed |
| title | Risk factors for small bowel angioectasia: The impact of visceral fat accumulation |
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