Vascular Dysfunction and Chronic Obstructive Pulmonary Disease: The Role of Redox Balance
Chronic obstructive pulmonary disease (COPD) is characterized by low pulmonary function, inflammation, free radical production, vascular dysfunction, and subsequently a greater incidence of cardiovascular disease. By administering an acute oral antioxidant cocktail to patients with COPD (n=30) and c...
Gespeichert in:
| Veröffentlicht in: | Hypertension (Dallas, Tex. 1979) Tex. 1979), 2014-03, Vol.63 (3), p.459-467 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 467 |
|---|---|
| container_issue | 3 |
| container_start_page | 459 |
| container_title | Hypertension (Dallas, Tex. 1979) |
| container_volume | 63 |
| creator | Ives, Stephen J. Harris, Ryan A. Witman, Melissa A.H. Fjeldstad, Anette S. Garten, Ryan S. McDaniel, John Wray, D. Walter Richardson, Russell S. |
| description | Chronic obstructive pulmonary disease (COPD) is characterized by low pulmonary function, inflammation, free radical production, vascular dysfunction, and subsequently a greater incidence of cardiovascular disease. By administering an acute oral antioxidant cocktail to patients with COPD (n=30) and controls (n=30), we sought to determine the role of redox balance in the vascular dysfunction of these patients. Using a double-blind, randomized, placebo-controlled, crossover design, patients with COPD and controls were ingested placebo or the antioxidant cocktail (vitamin C, vitamin E, α-lipoic acid) after which brachial artery flow-mediated dilation and carotid-radial pulse wave velocity were assessed using ultrasound Doppler. The patients exhibited lower baseline antioxidant levels (vitamin C and superoxide dismutase activity) and higher levels of oxidative stress (thiobarbituic acid reactive species) in comparison with controls. The patients also displayed lower basal flow-mediated dilation (P |
| doi_str_mv | 10.1161/HYPERTENSIONAHA.113.02255 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4476392</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>24324045</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3305-70ba6184d8cc609d5f3d2edeb54a3e6be45696155950bde2b976905fcd496e2d3</originalsourceid><addsrcrecordid>eNqNkEtvEzEUhS0EoqHlLyCzYDnFz5kYCaSQpqRS1VQhILqyPPYdZsAZV_ZMH_8eQ0qBrlhZOj7n3Hs_hF5SckhpSV8vL84X683i7OPJ6my2nGWRHxLGpHyEJlQyUQhZ8sdoQqgShaL0yx56ltI3QqgQonqK9pjgTBAhJ-jis0l29Cbio9vUjL0dutBj0zs8b2PoO4tXdRrimPUrwOej34bexFt81CUwCd7gTQt4HTzg0OA1uHCD3xtvegsH6EljfILnd-8--nS82MyXxenqw8l8dlpYzoksKlKbkk6Fm1pbEuVkwx0DB7UUhkNZQ75FlVRKJUntgNWqKhWRjXVClcAc30fvdr2XY70FZ6EfovH6MnbbvKgOptP__vRdq7-GK51RlFyxXKB2BTaGlCI091lK9E_e-gHvLHL9i3fOvvh7-H3yN-BseHVnyJyNb2JG06U_vimTqqqq7Hu7810HP0BM3_14DVG3YPzQ_sciPwBba6Bz</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Vascular Dysfunction and Chronic Obstructive Pulmonary Disease: The Role of Redox Balance</title><source>MEDLINE</source><source>American Heart Association Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Journals@Ovid Complete</source><creator>Ives, Stephen J. ; Harris, Ryan A. ; Witman, Melissa A.H. ; Fjeldstad, Anette S. ; Garten, Ryan S. ; McDaniel, John ; Wray, D. Walter ; Richardson, Russell S.</creator><creatorcontrib>Ives, Stephen J. ; Harris, Ryan A. ; Witman, Melissa A.H. ; Fjeldstad, Anette S. ; Garten, Ryan S. ; McDaniel, John ; Wray, D. Walter ; Richardson, Russell S.</creatorcontrib><description>Chronic obstructive pulmonary disease (COPD) is characterized by low pulmonary function, inflammation, free radical production, vascular dysfunction, and subsequently a greater incidence of cardiovascular disease. By administering an acute oral antioxidant cocktail to patients with COPD (n=30) and controls (n=30), we sought to determine the role of redox balance in the vascular dysfunction of these patients. Using a double-blind, randomized, placebo-controlled, crossover design, patients with COPD and controls were ingested placebo or the antioxidant cocktail (vitamin C, vitamin E, α-lipoic acid) after which brachial artery flow-mediated dilation and carotid-radial pulse wave velocity were assessed using ultrasound Doppler. The patients exhibited lower baseline antioxidant levels (vitamin C and superoxide dismutase activity) and higher levels of oxidative stress (thiobarbituic acid reactive species) in comparison with controls. The patients also displayed lower basal flow-mediated dilation (P<0.05), which was significantly improved with antioxidant cocktail (3.1±0.5 versus 4.7±0.6%; P<0.05; placebo versus antioxidant cocktail), but not controls (6.7±0.6 versus 6.9±0.7%; P>0.05; placebo versus antioxidant cocktail). The antioxidant cocktail also improved pulse wave velocity in patients with COPD (14±1 versus 11±1 m·s; P<0.05; placebo versus antioxidant cocktail) while not affecting controls (11±2 versus 10±1 m·s; P>0.05; placebo versus antioxidant). Patients with COPD exhibit vascular dysfunction, likely mediated by an altered redox balance, which can be acutely mitigated by an oral antioxidant. Therefore, free radically mediated vascular dysfunction may be an important mechanism contributing to this population’s greater risk and incidence of cardiovascular disease.</description><identifier>ISSN: 0194-911X</identifier><identifier>EISSN: 1524-4563</identifier><identifier>DOI: 10.1161/HYPERTENSIONAHA.113.02255</identifier><identifier>PMID: 24324045</identifier><identifier>CODEN: HPRTDN</identifier><language>eng</language><publisher>Hagerstown, MD: American Heart Association, Inc</publisher><subject>Aged ; Antioxidants - pharmacokinetics ; Antioxidants - therapeutic use ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; Brachial Artery - diagnostic imaging ; Brachial Artery - physiopathology ; Cardiology. Vascular system ; Chronic obstructive pulmonary disease, asthma ; Cross-Over Studies ; Disease Progression ; Double-Blind Method ; Endothelium, Vascular - physiopathology ; Female ; Follow-Up Studies ; Humans ; Hypertension - etiology ; Hypertension - metabolism ; Hypertension - physiopathology ; Male ; Medical sciences ; Oxidation-Reduction ; Pneumology ; Prognosis ; Pulmonary Disease, Chronic Obstructive - complications ; Pulmonary Disease, Chronic Obstructive - drug therapy ; Pulmonary Disease, Chronic Obstructive - metabolism ; Ultrasonography, Doppler ; Vascular Resistance - physiology ; Vasodilation - physiology</subject><ispartof>Hypertension (Dallas, Tex. 1979), 2014-03, Vol.63 (3), p.459-467</ispartof><rights>2014 American Heart Association, Inc</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3305-70ba6184d8cc609d5f3d2edeb54a3e6be45696155950bde2b976905fcd496e2d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,3674,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28259777$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24324045$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ives, Stephen J.</creatorcontrib><creatorcontrib>Harris, Ryan A.</creatorcontrib><creatorcontrib>Witman, Melissa A.H.</creatorcontrib><creatorcontrib>Fjeldstad, Anette S.</creatorcontrib><creatorcontrib>Garten, Ryan S.</creatorcontrib><creatorcontrib>McDaniel, John</creatorcontrib><creatorcontrib>Wray, D. Walter</creatorcontrib><creatorcontrib>Richardson, Russell S.</creatorcontrib><title>Vascular Dysfunction and Chronic Obstructive Pulmonary Disease: The Role of Redox Balance</title><title>Hypertension (Dallas, Tex. 1979)</title><addtitle>Hypertension</addtitle><description>Chronic obstructive pulmonary disease (COPD) is characterized by low pulmonary function, inflammation, free radical production, vascular dysfunction, and subsequently a greater incidence of cardiovascular disease. By administering an acute oral antioxidant cocktail to patients with COPD (n=30) and controls (n=30), we sought to determine the role of redox balance in the vascular dysfunction of these patients. Using a double-blind, randomized, placebo-controlled, crossover design, patients with COPD and controls were ingested placebo or the antioxidant cocktail (vitamin C, vitamin E, α-lipoic acid) after which brachial artery flow-mediated dilation and carotid-radial pulse wave velocity were assessed using ultrasound Doppler. The patients exhibited lower baseline antioxidant levels (vitamin C and superoxide dismutase activity) and higher levels of oxidative stress (thiobarbituic acid reactive species) in comparison with controls. The patients also displayed lower basal flow-mediated dilation (P<0.05), which was significantly improved with antioxidant cocktail (3.1±0.5 versus 4.7±0.6%; P<0.05; placebo versus antioxidant cocktail), but not controls (6.7±0.6 versus 6.9±0.7%; P>0.05; placebo versus antioxidant cocktail). The antioxidant cocktail also improved pulse wave velocity in patients with COPD (14±1 versus 11±1 m·s; P<0.05; placebo versus antioxidant cocktail) while not affecting controls (11±2 versus 10±1 m·s; P>0.05; placebo versus antioxidant). Patients with COPD exhibit vascular dysfunction, likely mediated by an altered redox balance, which can be acutely mitigated by an oral antioxidant. Therefore, free radically mediated vascular dysfunction may be an important mechanism contributing to this population’s greater risk and incidence of cardiovascular disease.</description><subject>Aged</subject><subject>Antioxidants - pharmacokinetics</subject><subject>Antioxidants - therapeutic use</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Brachial Artery - diagnostic imaging</subject><subject>Brachial Artery - physiopathology</subject><subject>Cardiology. Vascular system</subject><subject>Chronic obstructive pulmonary disease, asthma</subject><subject>Cross-Over Studies</subject><subject>Disease Progression</subject><subject>Double-Blind Method</subject><subject>Endothelium, Vascular - physiopathology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Hypertension - etiology</subject><subject>Hypertension - metabolism</subject><subject>Hypertension - physiopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Oxidation-Reduction</subject><subject>Pneumology</subject><subject>Prognosis</subject><subject>Pulmonary Disease, Chronic Obstructive - complications</subject><subject>Pulmonary Disease, Chronic Obstructive - drug therapy</subject><subject>Pulmonary Disease, Chronic Obstructive - metabolism</subject><subject>Ultrasonography, Doppler</subject><subject>Vascular Resistance - physiology</subject><subject>Vasodilation - physiology</subject><issn>0194-911X</issn><issn>1524-4563</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkEtvEzEUhS0EoqHlLyCzYDnFz5kYCaSQpqRS1VQhILqyPPYdZsAZV_ZMH_8eQ0qBrlhZOj7n3Hs_hF5SckhpSV8vL84X683i7OPJ6my2nGWRHxLGpHyEJlQyUQhZ8sdoQqgShaL0yx56ltI3QqgQonqK9pjgTBAhJ-jis0l29Cbio9vUjL0dutBj0zs8b2PoO4tXdRrimPUrwOej34bexFt81CUwCd7gTQt4HTzg0OA1uHCD3xtvegsH6EljfILnd-8--nS82MyXxenqw8l8dlpYzoksKlKbkk6Fm1pbEuVkwx0DB7UUhkNZQ75FlVRKJUntgNWqKhWRjXVClcAc30fvdr2XY70FZ6EfovH6MnbbvKgOptP__vRdq7-GK51RlFyxXKB2BTaGlCI091lK9E_e-gHvLHL9i3fOvvh7-H3yN-BseHVnyJyNb2JG06U_vimTqqqq7Hu7810HP0BM3_14DVG3YPzQ_sciPwBba6Bz</recordid><startdate>201403</startdate><enddate>201403</enddate><creator>Ives, Stephen J.</creator><creator>Harris, Ryan A.</creator><creator>Witman, Melissa A.H.</creator><creator>Fjeldstad, Anette S.</creator><creator>Garten, Ryan S.</creator><creator>McDaniel, John</creator><creator>Wray, D. Walter</creator><creator>Richardson, Russell S.</creator><general>American Heart Association, Inc</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>201403</creationdate><title>Vascular Dysfunction and Chronic Obstructive Pulmonary Disease: The Role of Redox Balance</title><author>Ives, Stephen J. ; Harris, Ryan A. ; Witman, Melissa A.H. ; Fjeldstad, Anette S. ; Garten, Ryan S. ; McDaniel, John ; Wray, D. Walter ; Richardson, Russell S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3305-70ba6184d8cc609d5f3d2edeb54a3e6be45696155950bde2b976905fcd496e2d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aged</topic><topic>Antioxidants - pharmacokinetics</topic><topic>Antioxidants - therapeutic use</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Brachial Artery - diagnostic imaging</topic><topic>Brachial Artery - physiopathology</topic><topic>Cardiology. Vascular system</topic><topic>Chronic obstructive pulmonary disease, asthma</topic><topic>Cross-Over Studies</topic><topic>Disease Progression</topic><topic>Double-Blind Method</topic><topic>Endothelium, Vascular - physiopathology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Hypertension - etiology</topic><topic>Hypertension - metabolism</topic><topic>Hypertension - physiopathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Oxidation-Reduction</topic><topic>Pneumology</topic><topic>Prognosis</topic><topic>Pulmonary Disease, Chronic Obstructive - complications</topic><topic>Pulmonary Disease, Chronic Obstructive - drug therapy</topic><topic>Pulmonary Disease, Chronic Obstructive - metabolism</topic><topic>Ultrasonography, Doppler</topic><topic>Vascular Resistance - physiology</topic><topic>Vasodilation - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ives, Stephen J.</creatorcontrib><creatorcontrib>Harris, Ryan A.</creatorcontrib><creatorcontrib>Witman, Melissa A.H.</creatorcontrib><creatorcontrib>Fjeldstad, Anette S.</creatorcontrib><creatorcontrib>Garten, Ryan S.</creatorcontrib><creatorcontrib>McDaniel, John</creatorcontrib><creatorcontrib>Wray, D. Walter</creatorcontrib><creatorcontrib>Richardson, Russell S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Hypertension (Dallas, Tex. 1979)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ives, Stephen J.</au><au>Harris, Ryan A.</au><au>Witman, Melissa A.H.</au><au>Fjeldstad, Anette S.</au><au>Garten, Ryan S.</au><au>McDaniel, John</au><au>Wray, D. Walter</au><au>Richardson, Russell S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vascular Dysfunction and Chronic Obstructive Pulmonary Disease: The Role of Redox Balance</atitle><jtitle>Hypertension (Dallas, Tex. 1979)</jtitle><addtitle>Hypertension</addtitle><date>2014-03</date><risdate>2014</risdate><volume>63</volume><issue>3</issue><spage>459</spage><epage>467</epage><pages>459-467</pages><issn>0194-911X</issn><eissn>1524-4563</eissn><coden>HPRTDN</coden><abstract>Chronic obstructive pulmonary disease (COPD) is characterized by low pulmonary function, inflammation, free radical production, vascular dysfunction, and subsequently a greater incidence of cardiovascular disease. By administering an acute oral antioxidant cocktail to patients with COPD (n=30) and controls (n=30), we sought to determine the role of redox balance in the vascular dysfunction of these patients. Using a double-blind, randomized, placebo-controlled, crossover design, patients with COPD and controls were ingested placebo or the antioxidant cocktail (vitamin C, vitamin E, α-lipoic acid) after which brachial artery flow-mediated dilation and carotid-radial pulse wave velocity were assessed using ultrasound Doppler. The patients exhibited lower baseline antioxidant levels (vitamin C and superoxide dismutase activity) and higher levels of oxidative stress (thiobarbituic acid reactive species) in comparison with controls. The patients also displayed lower basal flow-mediated dilation (P<0.05), which was significantly improved with antioxidant cocktail (3.1±0.5 versus 4.7±0.6%; P<0.05; placebo versus antioxidant cocktail), but not controls (6.7±0.6 versus 6.9±0.7%; P>0.05; placebo versus antioxidant cocktail). The antioxidant cocktail also improved pulse wave velocity in patients with COPD (14±1 versus 11±1 m·s; P<0.05; placebo versus antioxidant cocktail) while not affecting controls (11±2 versus 10±1 m·s; P>0.05; placebo versus antioxidant). Patients with COPD exhibit vascular dysfunction, likely mediated by an altered redox balance, which can be acutely mitigated by an oral antioxidant. Therefore, free radically mediated vascular dysfunction may be an important mechanism contributing to this population’s greater risk and incidence of cardiovascular disease.</abstract><cop>Hagerstown, MD</cop><pub>American Heart Association, Inc</pub><pmid>24324045</pmid><doi>10.1161/HYPERTENSIONAHA.113.02255</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0194-911X |
| ispartof | Hypertension (Dallas, Tex. 1979), 2014-03, Vol.63 (3), p.459-467 |
| issn | 0194-911X 1524-4563 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4476392 |
| source | MEDLINE; American Heart Association Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete |
| subjects | Aged Antioxidants - pharmacokinetics Antioxidants - therapeutic use Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Brachial Artery - diagnostic imaging Brachial Artery - physiopathology Cardiology. Vascular system Chronic obstructive pulmonary disease, asthma Cross-Over Studies Disease Progression Double-Blind Method Endothelium, Vascular - physiopathology Female Follow-Up Studies Humans Hypertension - etiology Hypertension - metabolism Hypertension - physiopathology Male Medical sciences Oxidation-Reduction Pneumology Prognosis Pulmonary Disease, Chronic Obstructive - complications Pulmonary Disease, Chronic Obstructive - drug therapy Pulmonary Disease, Chronic Obstructive - metabolism Ultrasonography, Doppler Vascular Resistance - physiology Vasodilation - physiology |
| title | Vascular Dysfunction and Chronic Obstructive Pulmonary Disease: The Role of Redox Balance |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-21T19%3A50%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Vascular%20Dysfunction%20and%20Chronic%20Obstructive%20Pulmonary%20Disease:%20The%20Role%20of%20Redox%20Balance&rft.jtitle=Hypertension%20(Dallas,%20Tex.%201979)&rft.au=Ives,%20Stephen%20J.&rft.date=2014-03&rft.volume=63&rft.issue=3&rft.spage=459&rft.epage=467&rft.pages=459-467&rft.issn=0194-911X&rft.eissn=1524-4563&rft.coden=HPRTDN&rft_id=info:doi/10.1161/HYPERTENSIONAHA.113.02255&rft_dat=%3Cpubmed_cross%3E24324045%3C/pubmed_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/24324045&rfr_iscdi=true |