Pathophysiological role of microRNA-29 in pancreatic cancer stroma

Dense fibrotic stroma associated with pancreatic ductal adenocarcinoma (PDAC) is a major obstacle for drug delivery to the tumor bed and plays a crucial role in pancreatic cancer progression. Current, anti-stromal therapies have failed to improve tumor response to chemotherapy and patient survival....

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Veröffentlicht in:	Scientific reports 2015-06, Vol.5 (1), p.11450, Article 11450
Hauptverfasser:	Kwon, Jason J., Nabinger, Sarah C., Vega, Zachary, Sahu, Smiti Snigdha, Alluri, Ravi K., Abdul-Sater, Zahi, Yu, Zhangsheng, Gore, Jesse, Nalepa, Grzegorz, Saxena, Romil, Korc, Murray, Kota, Janaiah
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/106 13/95 14/32 42/109 631/337/384/331 64/60 692/699/67/327 Adenocarcinoma Animals Antineoplastic Agents - therapeutic use Carcinoma, Pancreatic Ductal - drug therapy Carcinoma, Pancreatic Ductal - genetics Cell culture Cell Line, Tumor Cell Survival - genetics Chemotherapy Drug delivery Enzyme Activation - genetics Extracellular matrix Extracellular Matrix - genetics Extracellular Matrix - metabolism Fibroblasts Fibroblasts - cytology Fibrosis - genetics Fibrosis - pathology Humanities and Social Sciences Humans Mice Mice, Inbred C57BL Mice, Transgenic MicroRNAs - genetics miRNA Molecular modelling multidisciplinary Pancreas - metabolism Pancreas - pathology Pancreatic cancer Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - genetics Pancreatic Stellate Cells - cytology Proto-Oncogene Proteins p21(ras) - metabolism Science Smad3 protein Smad3 Protein - metabolism Stellate cells Stromal cells Transforming Growth Factor beta - metabolism Transforming growth factor-b1 Tumor Microenvironment Tumors
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