SAMHD1 Limits HIV-1 Antigen Presentation by Monocyte-Derived Dendritic Cells

Monocyte-derived dendritic cells (MDDC) stimulate CD8 cytotoxic T lymphocytes (CTL) by presenting endogenous and exogenous viral peptides via major histocompatibility complex class I (MHC-I) molecules. MDDC are poorly susceptible to HIV-1, in part due to the presence of SAMHD1, a cellular enzyme tha...

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Veröffentlicht in:	Journal of virology 2015-07, Vol.89 (14), p.6994-7006
Hauptverfasser:	Ayinde, Diana, Bruel, Timothée, Cardinaud, Sylvain, Porrot, Françoise, Prado, Julia G, Moris, Arnaud, Schwartz, Olivier
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigen Presentation CD8-Positive T-Lymphocytes - immunology Cells, Cultured Cellular Response to Infection Dendritic Cells - immunology Genetics HIV Antigens - immunology HIV-1 - immunology Human immunodeficiency virus Human immunodeficiency virus 1 Human immunodeficiency virus 2 Humans Immunology Life Sciences Microbiology and Parasitology Monomeric GTP-Binding Proteins SAM Domain and HD Domain-Containing Protein 1 Spotlight T-Lymphocytes, Cytotoxic - immunology Vesicular stomatitis virus
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