Complexity of Neutralizing Antibodies against Multiple Dengue Virus Serotypes after Heterotypic Immunization and Secondary Infection Revealed by In-Depth Analysis of Cross-Reactive Antibodies

The four serotypes of dengue virus (DENV) cause the most important and rapidly emerging arboviral diseases in humans. The recent phase 2b and 3 studies of a tetravalent dengue vaccine reported a moderate efficacy despite the presence of neutralizing antibodies, highlighting the need for a better und...

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Veröffentlicht in:	Journal of virology 2015-07, Vol.89 (14), p.7348-7362
Hauptverfasser:	Tsai, Wen-Yang, Durbin, Anna, Tsai, Jih-Jin, Hsieh, Szu-Chia, Whitehead, Stephen, Wang, Wei-Kung
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antibodies, Neutralizing - blood Antibodies, Neutralizing - immunology Antibodies, Viral - blood Antibodies, Viral - immunology Antibody Affinity Coinfection Cross Reactions Dengue - immunology Dengue - prevention & control Dengue - virology Dengue Vaccines - administration & dosage Dengue Vaccines - immunology Dengue virus Dengue Virus - immunology Humans Immunity, Heterologous Immunoglobulin G - blood Immunoglobulin G - immunology Neutralization Tests Pathogenesis and Immunity Serogroup Spotlight Vaccines, Attenuated - administration & dosage Vaccines, Attenuated - immunology
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